The role of insulin-like growth factor II in the malignant transformation of rat liver oval cells

Hepatology

Volumn 25, Issue 4, 1997, Pages 900-905

  Zhang, Nong ^a   Siegel, Kerstin ^a   Odenthal, Margarete ^a   Becker, Roger ^a   Oesch, Franz ^a   Dienes, Hans Peter ^a   Schirmacher, Peter ^a   Steinberg, Pablo ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

NEUTRALIZING ANTIBODY; SOMATOMEDIN B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CELL PROLIFERATION; DNA DETERMINATION; DOWN REGULATION; GENE EXPRESSION; LIVER TUMOR; MALIGNANT TRANSFORMATION; MITOGENESIS; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT;

ANIMALS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; INSULIN-LIKE GROWTH FACTOR II; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MITOGENS; NEUTRALIZATION TESTS; ONCOGENES; RATS;

EID: 0030961765     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510250419     Document Type: Article

References (20)

1. LeRoith D (ed). Insulin-Like Growth Factors: Molecular and Cellular Aspects. Boca Raton: CRC Press, 1991.
2. Rotwein P. Structure, evolution, expression and regulation of insulin-like growth factors I and II. Growth Factors 1991;5:3-18.
3. Roth RA. Structure of the receptor for insulin-like growth factor II: the puzzle amplified. Science 1988;239:1269-1271.
4. Czech MP. Signal transmission by the insulin-like growth factors. Cell 1989;59:235-238.
5. Neely EK, Beukers MW, Oh Y, Cohen P, Rosenfeld RG. Insulin-like growth factor receptors. Acta Paediatr Scand 1991;372(suppl):116-123.
6. Nissley P, Kiess W, Sklar MM. The IGF-II/mannose-6-phosphate receptor. In: LeRoith D, ed. Insulin-Like Growth Factors: Molecular and Cellular Aspects. Boca Raton: CRC Press, 1991:111-150.
7. Moxham C, Jacobs S. Insulin-like growth factor receptors. In: Schofield PN, ed. The Insulin-Like Growth Factors: Structure and Biological Functions. Oxford: Oxford University Press, 1992:80-110.
8. Kornfeld S. Structure and function of the M6P/IGF-II receptors. Annu Rev Biochem 1992;61:307-330.
9. Morgan DO, Jarnagin K, Roth RA. Purification and characterization of the receptor for insulin-like growth factor I. Biochemistry 1986;25:5560-5564.
10. Ullrich A, Gray A, Tam AW, Yang-Feng T, Tsubokawa M, Collins C, Henzel W, et al. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J 1986;5:2503-2512.
11. Morgan DO, Edman JC, Standring DR, Fried VA, Smith MC, Roth RA, Rutter WJ. Insulin-like growth factor II receptor as a multifunctional binding protein. Nature 1987;329:301-307.
12. Soares MB, Ishii DN, Efstriatiadis A. Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA. Nucleic Acids Res 1985;14:1129-1134.
13. Gray A, Tam AW, Dull TJ, Hayflick J, Pintar J, Cavenee WK, Koufos A, et al. Tissue-specific and developmentally regulated transcription of the insulin-like growth factor II gene. DNA 1987;6:283-295.
14. DeChiara TM, Robertson EJ, Efstriatiadis A. Parental imprinting of the mouse insulin-like growth factor II gene. Cell 1991;64:849-859.
15. Giannoukakis N, Deal C, Pacquette J, Goodyer C, Polychronakos C. Parental genomic imprinting of the human IGF2 gene. Nat Genet 1993;4:98-101.
16. Fu XX, Su CY, Lee Y, Hintz R, Biempica L, Snyder R, Regler CE. Insulin-like growth factor II expression and oval cell proliferation associated with hepatocarcinogenesis in woodchuck hepatitis virus carriers. J Virol 1988; 62:3422-3430.
17. Yang DY, Rogler CE. Analysis of insulin-like growth factor II (IGF II) expression in neoplastic nodules and hepatocellular carcinomas of woodchucks utilizing "in situ" hybridization and immunocytochemistry. Carcinogenesis 1991;12:1893-1901.
18. Norstedt G, Levinovitz A, Möller C, Eriksson LC, Andersson G. Expression of insulin-like growth factor I (IGF-I) and IGF-II mRNA during hepatic development, proliferation and carcinogenesis in the rat. Carcinogenesis 1988;9:209-213.
19. Ueno T, Takahashi K, Matsuguchi T, Ikejiri K, Endo H, Yamamoto M. Reactivation of insulin-like growth factor II gene during hepatocarcinogenesis. Carcinogenesis 1988;9:1779-1783.
20. Schirmacher P, Held WA, Chisari F, Rustum Y, Wang H-P, Yang D, Rogler CE. Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth. Cancer Res 1992;52:2549-2556.