Electronic and structural requirements for metabolic activation of butylated hydroxytoluene analogs to their quinone methides, intermediates responsible for lung toxicity in mice

Biological and Pharmaceutical Bulletin

Volumn 20, Issue 5, 1997, Pages 571-573

  Yamamoto, Kenji ^a   Kato, Sachiko ^a   Tajima, Kazuo ^b   Mizutani, Tamio ^b  

^a HOKURIKU UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY   (Japan)

Author keywords

BHT quinone methide; Butylated hydroxytoluene; Lung toxicity; MO calculation; Structure activity relationship

Indexed keywords

ANTIOXIDANT; BUTYLCRESOL; QUINONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG DETOXIFICATION; DRUG METABOLISM; DRUG OXIDATION; DRUG POTENCY; LUNG TOXICITY; LUNG WEIGHT; MALE; MOUSE; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 0030961661     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.20.571     Document Type: Article

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