Delivery of azithromycin to Chlamydia trachomatis-infected polarized human endometrial epithelial cells by polymorphonuclear leucocytes

Journal of Antimicrobial Chemotherapy

Volumn 39, Issue 5, 1997, Pages 623-630

  Paul, T R ^a   Knight, S T ^a   Raulston, J E ^a   Wyrick, P B ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; MACROLIDE;

ARTICLE; CELL LINE; CHLAMYDIA TRACHOMATIS; DRUG DELIVERY SYSTEM; EPITHELIUM CELL; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; MEMBRANE VESICLE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS;

ANTI-BACTERIAL AGENTS; AZITHROMYCIN; CELL LINE; CELL MOVEMENT; CELL POLARITY; CHLAMYDIA TRACHOMATIS; DRUG DELIVERY SYSTEMS; ENDOMETRIUM; FEMALE; HUMANS; NEUTROPHILS;

EID: 0030961304     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/39.5.623     Document Type: Article

References (25)

1. Paavonen, J. & Wolner-Hanssen, P. (1989). Chlamydia trachomatis: a major threat to reproduction. Human Reproduction 4, 111-24.
2. Kiviat, N. B., Paavonen, J. A., Brockway, J., Critchlow, C. W., Brunham, R. C., Stevens, C. E. et al. (1985). Cytological manifestations of cervical and vaginal infections. 1. Epithelial and inflammatory cellular changes. Journal of the American Medical Association 253, 989-96.
3. Arya, O. P., Mallinson, H., Andrews, B. E. & Sillis, M. (1984). Diagnosis of urethritis: role of polymorphonuclear leukocyte counts in Gram-stained urethral smears. Sexually Transmitted Diseases 11, 10-7.
4. Brunham, R. C., Paavonen, J., Stevens, C. E., Kiviat, N., Kuo, C. C., Critchlow, C. W. et al. (1984). Mucopurulent cervicitis - the ignored counterpart in women of urethritis in men. New England Journal of Medicine 311, 1-6.
5. Gladue, R. P., Bright, G. M., Isaacson, R. E. & Newborg, M. F. (1989), In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection. Antimicrobial Agents and Chemotherapy 33, 277-82.
6. Gladue, R. P. & Snider, M. E. (1990). Intracellular accumulation of azithromycin by cultured human fibroblasts. Antimicrobial Agents and Chemotherapy 34, 1056-60.
7. Meyer, A. P., Bril-Bazuin, C., Mattie, H. & van den Broek, P. J. (1993). Uptake of azithromycin by human monocytes and enhanced intracellular antibacterial activity against Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 37, 2318-22.
8. Panteix, G., Guillaumond, B., Harf, R., Desbos, A., Sapin, V., Leclercq, M. et al. (1993). In-vitro concentration of azithromycin in human phagocytic cells. Journal of Antimicrobial Chemotherapy 31, Suppl. E, 1-4.
9. Frank, M. O., Sullivan, G. W., Carper, H. T. & Mandell, G. L. (1992). In vitro demonstration of transport and delivery of antibiotics by polymorphonuclear leukocytes. Antimicrobial Agents and Chemotherapy 36, 2584-8.
10. Foulds, G., Shepard, R. M. & Johnson, R. B. (1990). The pharmacokinetics of azithromycin in human serum and tissues. Journal of Antimicrobial Chemotherapy 25, Suppl. A, 73-82.
11. Girard, A. E., Girard, D., English, A. R., Gootz, T. D., Cimochowski, C. R., Faiella, J. A. et al. (1987). Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution. Antimicrobial Agents and Chemotherapy 31, 1948-54.
12. Donowitz, G. R. & Earnhardt, K. I. (1993). Azithromycin inhibition of intracellular Legionella micdadei. Antimicrobial Agents and Chemotherapy 37, 2261-4.
13. Wyrick, P. B., Davis, C. H., Knight, S. T. & Choong, J. (1993a). In-vitro activity of azithromycin on Chlamydia trachomatis infected, polarized human endometrial epithelial cells. Journal of Antimicrobial Chemotherapy 31, 139-50.
14. Raulston, J. E. (1994). Pharmacokinetics of azithromycin and erythromycin in human endometrial epithelial cells and in cells infected with Chlamydia trachomatis. Journal of Antimicrobial Chemotherapy 34, 765-76.
15. Martin, D. H., Mroczkowski, T. F., Dalu, Z. A., McCarty, J., Jones, R. B., Hopkins, S. J. et al. (1992). A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. New England Journal of Medicine 327, 921-5.
16. Tam, J. E., Knight, S. T., Davis, C. H. & Wyrick, P. B. (1992). Eukaryotic cells grown on microcarrier beads offer a cost-efficient way to propagate Chlamydia trachomatis. Biotechniques 13, 374-8.
17. Moorman, D. R., Sixbey, J. W. & Wyrick, P. B. (1986). Interaction of Chiamydia trachomatis with human genital epithelium in culture. Journal of General Microbiology 132, 1055-67.
18. Wyrick, P. B., Gerbig, D. G., Knight, S. T. & Raulston, J. E. (1996). Accelerated development of genital Chiamydia trachomatis serovar E in McCoy cells grown on microcarrier beads. Microbiol Pathogenesis 20, 31-40.
19. Wyrick, P. B., Davis, C. H., Knight, S. T., Choong, J., Raulston, J. E. & Schramm, N. (1993). An in vitro human epithelial cell culture system for studying the pathogenesis of Chlamydia trachomatis. Sexually Transmitted Diseases 20, 248-56.
20. Wyrick, P. B., Choong, J., Davis, C. H., Knight, S. T., Royal, M. O., Maslow, A. S. et al. (1989). Entry of genital Chiamydia trachomatis into polarized human epithelial cells. Infection and Immunity 57, 2378-89.
21. Karimi, S. T., Schloemer, R. H. & Wilde, C. E. (1989). Accumulation of chlamydial lipopolysaccharide antigen in plasma membranes of infected cells. Infection and Immunity 57, 1780-5.
22. Wyrick, P. B., Choong, J., Knight, S. T., Goyeau, D., Stuart, E. S. & MacDonald, A. B. (1994). Chiamydia trachomatis antigens on the surface of infected human endometrial epithelial cells. Immunology and Infectious Diseases 4, 131-41.
23. Wilde, C. E., Karimi, S. T. & Haak, R. A. (1986). Cell surface alterations during chlamydial infection. In Microbiology - 1986 (Leive, L., Bonventre, P. F., Morello, J. A., Silver, S. D, & Wu, H. C., Eds), pp. 96-8. American Society for Microbiology, Washington, DC.
24. Patton, D. L., Wang, S.-K. & Kuo, C.-C. (1995). The activity of azithromycin on the infectivity of Chiamydia trachomatis in human amniotic cells. Journal of Antimicrobial Chemotherapy 36, 951-9.
25. Engel, J. N. (1992). Azithromycin-induced block of elementary body formation in Chiamydia trachomatis. Antimicrobial Agents and Chemotherapy 36, 2304-9.