Safety and efficacy of i.v. bolus injection of SUN9216 (Modified tissue plasminogen activator) in acute myocardial infarction: Clinical early phase II study

Japanese Pharmacology and Therapeutics

Volumn 25, Issue 1, 1997, Pages 227-224

  Yui, Yoshiki ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE; LANOTEPLASE; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; BLOOD CLOT LYSIS; BOLUS INJECTION; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; MALE; PHASE 2 CLINICAL TRIAL; PLASMINOGEN ACTIVATION; TRANSLUMINAL CORONARY ANGIOPLASTY; TREATMENT OUTCOME;

EID: 0030961142     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Reimer KA et al : The wavefront phenomenon of ischemic cell death ; 1. myocardial infarct size vs duration of coronary occlusion in dogs. Circulation 56(5) : 786-794, 1977
2. Hochman JS, Choo H : Limitation of myocardial infarct expansion by reperfusion independent of myocardial salvage. Circulation 75(1) : 299-306, 1987
3. Werf FV, Arnold AE : Intravenous tissue plasminogen activator and size of infarct, left ventricular function, and survival in acute myocardial infarction. Br Med J 297 : 1374-1379, 1988
4. National Heart Foundation of Australia Coronary Thrombolysis Group : Coronary thrombolysis and myocardial salvage by tissue plasminogen activator given up to 4 hours after onset of myocardial infarction. Lancet i : 203-207, 1988
5. White HD et al : Effect of intravenous streptokinase as compared with that of tissue plasminogen activator on left ventricular function after first myocardial infarction. New Engl J Med 320(13) : 817-821, 1989
6. Topol EJ et al : A randomized trial of late reperfusion therapy for acute myocardial infarction. Circulation 85(6) : 2090-2099, 1992
7. Collen D et al : Pharmacokinetics and thrombolytic properties of deletion mutant of human tissue-type plasminogen activator in rabbits. Blood 71(1) : 216-219, 1988
8. Larsen GR et al : Pharmacokinetic and distribution analysis of variant forms of tissue-type plasminogen activator with prolonged clearance in rat. Blood 73(7) : 1842-1850, 1989
9. The TIMI Study Group : The thrombolysis in myocardial infarction (TIMI) trial. New Engl J Med 312(14) : 932-936, 1985
10. Cox JL et al : Stranger in a strange land ; The pathogenesis of saphenous vein graft stenosis with emphasis on structural and functional differences between veins and arteries. Prog Cardiovasc Dis 34 (1) : 45-68, 1991
11. The GUSTO Investigators : An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. New Engl J Med 329(10) : 673-682, 1993
12. Califf RM : Evaluation of combination thrombolytic therapy and timing of cardiac catheterization in acute myocardial infarction ; Results of thrombolysis and angioplasty in myocardial infarction-phase 5 randomized trial. Circulation 83(5) : 1543-1556, 1991
13. Rapaport E : Thrombolysis, anticoagulation, and reocclusion. Am J Cardiol 67 : 17E-22E, 1991