Plasma catecholamine and lymphocyte β2-adrenergic receptor alterations in elderly Alzheimer caregivers under stress

Psychosomatic Medicine

Volumn 59, Issue 3, 1997, Pages 251-256

  Mills, Paul J ^a,d   Ziegler, Michael G ^b   Patterson, Thomas ^a,c   Dimsdale, Joel E ^a   Hauger, Richard ^a,c   Irwin, Michael ^a,c   Grant, Igor ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^d UCSD MEDICAL CENTER   (United States)

Author keywords

Alzheimer caregivers; Elderly; Plasma catecholamine; Stress; adrenergic

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CATECHOLAMINE; CYCLIC AMP; HYDROCORTISONE;

AGED; ALZHEIMER DISEASE; ARTICLE; CAREGIVER; CATECHOLAMINE BLOOD LEVEL; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HYDROCORTISONE BLOOD LEVEL; INTERVIEW; LYMPHOCYTE; MALE; MENTAL STRESS; PRIORITY JOURNAL; RECEPTOR DENSITY; RECEPTOR SENSITIVITY; SPOUSE;

EID: 0030960878     PISSN: 00333174     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006842-199705000-00008     Document Type: Article

References (42)

1. Mills PJ, Dimsdale JE. The promise of adrenergic receptor studies in psychophysiologic research. II: Applications, limitations, and progress. Psychosom Med 55:448-457, 1993
2. Klenerova V, Sida P: Changes in beta-adrenergic receptors in the neurohypophysis and intermediate lobe of rat hypophysis exposed to stress. Physiol Res 43(5):289-292, 1994
3. Klimek V, Papp M: The effect of MK-801 and imipramine on beta-adrenergic and 5-HT2 receptors in the chronic mild stress model of depression in rats. Pol J Pharmacol 46(1-2): 67-69, 1994
4. Kubera M, Skowron-Cendrzak A, Mazur-Kolecka B, et al: Stress-induced changes in muscarinic and beta-adrenergic binding sites on rat thymocytes and lymphocytes. J Neuroimmunol 37(3):229-235, 1992
5. Dimsdale J, Mills P, Patterson T, et al: The effects of chronic stress on β-adrenergic receptors. Psychosom Med 56:290-295, 1994
6. Brodde O, Kretsch R, Ikezono K, et al: Human β-adrenoceptors: Relation of myocardial and lymphocyte β-adreneoceptor density. Science 231:1584-1585, 1986
7. Aarons R, Nies A, Gerber J, et al: Decreased β-adrenergic receptor density on human lymphocytes after chronic treatment with agonists. J Pharmacol Exp Ther 224:1-6, 1983
8. 2-adrenergic-dependent mechanism. Circulation 86(1):203-213, 1992
9. Bonneau RH, Kiecolt-Glaser JK, Glaser R: Stress-induced modulation of the immune response. Ann NY Acad Sci 594:253-269, 1991
10. Kiecolt-Glaser J, Dura J, Speicher C, et al: Spousal caregivers of dementia victims: Longitudinal changes in immunity and health. Psychosom Med 53:345-362, 1991
11. Davies AO, Lefkowitz RJ: Regulation of β-adrenegic receptors by steroid hormones. Annu Rev Physiol 46:119-130, 1984
12. Feldman RD, Limbird LE, Nadeau J, et al: Dynamic regulation of leukocyte β-adrenergic receptor-agonist interactions by physiological changes in circulating catecholamines. J Clin Invest 72:164-170, 1983
13. 2-adrenoceptor density in human lymphocytes. J Cardiovasc Pharmacol 8:S70-873, 1986
14. Mills PJ, Dimsdale JE, Ziegler MG, et al: Sympathetic alterations following sodium restriction and short-term captopril. J Am Coll Cardiol 21:177-181, 1993
15. Stiles GL: Drug and hormonal regulation of the β-adrenergic receptor-adenylate cyclase system. In Perkins JP (ed), The β-Adrenergic Receptors. Clifton, NJ, Humana Press, 1995, 345-386
16. Dohronwend B, Dohrenwend D: Some issues on stressful life events. J Nerv Ment Dis 166:7-15, 1978
17. Brown G, Harris: Life Events and Illnesses. The Guilford Press, New York, 1989, 295-312
18. Grant I, Brown G, Harris T, et al: Severely threatening events and marked life difficulties precedding onset or exacerbation of multiple sclerosis. J Neurol Neuropsychiatry 52:8-13, 1989
19. Mills PJ, Dimsdale JE, Ziegler M, et al: Racial differences in epinephrine and β-adrenergic receptors. Hypertension 25:88-91, 1995
20. Insel PA: Adrenergic receptors, G proteins, and cell regulation: Implications foraging research. Exp Gerontol 28(4-5): 341-348, 1993
21. Seamon K, Padgett W, Daly J: Forskolin: Unique diterpene activator of adenylate cyclase in membranes and in intact cells. Proc Natl Acad Sci 78:3363-3367, 1981
22. Landman R, Burgisser E, Wesp M, et al: β-Adrenergic receptors are different in subpopulations of human circulating lymphocytes. J Recept Res 4:37-50, 1984
23. Mills PJ, Berry C, Dimsdale J, et al: Lymphocyte subset redistribution in response to acute experimental stress: Effects of gender, ethnicity, and the sympathetic nervous system. Brain Behav Immun 9:61-69, 1995
24. Kennedy B, Ziegler MG: A more sensitive radioenzymatic assay for catecholamines. Life Sci 47:2143-2153, 1990
25. Parry BL, Hauger R, Lin E, et al: Neuroendocrine effects of light therapy in late luteal phase dysphoric disorder. Biol Psychiatry 36(6):356-364, 1994
26. Palmer D, Ziegler MG, Lake CR: Response of norepinephrine and blood pressure to stress increases with age. J Gerontol 33:482-487, 1978
27. Freedman RR, Moten M: Gender differences in modulation of peripheral vascular adrenoceptors. Ann Behav Med 17:15-18, 1995
28. Halper J, Mann J, Weksler M, et al: Beta-adrenergic receptors and cyclic AMP levels in intact human lymphocytes: Effects of age and gender. Life Sci 35:855-865, 1984
29. Nies AS, Andros EA, Gerber JG: Platelet alpha 2-adrenergic receptor responsiveness is increased in elderly men but not in elderly women. Clin Pharmacol Ther 52(6):605-608, 1992
30. Feldman RD, Limbird LE, Nadeau J, et al: Leukocyte beta-receptor alterations in hypertensive subjects. J Clin Invest 73:648-653, 1984
31. Jennings G, Bobik A, Esler M, et al: Relationship between maximum chronotropic response to isoproterenol in man and generation of cyclic AMP by lymphocytes. Circ Res 46(6):49-50, 1980
32. Irwin M, Brown M, Patterson T, et al: Neuropeptide Y and natural killer cell activity: Findings in depression and Alzheimer caregiver stress. FASEB 5:3100-3107, 1991
33. Michel M, Otto-Erich O, Insel P: Peripheral adrenergic receptors in hypertension. Hypertension 16:107-120, 1990
34. Hermanussen M, Jensen F, Hirsch N, et al: Acute and chronic effects of winter swimming on LH, FSH, prolactin, growth hormone, TSH, cortisol, serum glucose, and insulin. Arctic Med Res 54(1):45-51, 1995
35. Riemer R, Wu Y, Bottare S, et al: Estrogen reduces β-adrenoceptor-mediated cAMP production and the concentration of the guanyl nucleotide-regulatory protein, Gs, in rabbit myometrium. Clin Pharmacol Ther 33:389-395, 1988
36. Boulet A, Fortier M: Sex steroid regulation of β-adrenergic sensitive adenylate cyclase in rabbit myometrial cells in primary culture. Life Sci 42:829-840, 1988
37. De Blasi A, Parruti G, Sallese M: Regulation of G protein-coupled receptor kinase subtypes in activated T lymphocytes. Selective increase of beta-adrenergic receptor kinase 1 and 2. J Clin Invest 95(1):203-210, 1995
38. Ziegler MG: Catechlamine measurement in behavioral research. In Schneiderman N, Weiss S, and Kaufmann P eds, Handbook of Research Methods in Cardiovascular Behavioral Medicine. New York, Plenum Press, 1989, 167-183
39. Mader S, Robbins A, Rubenstein L, et al: Effect of age and posture on human lymphocyte adenylate cyclase activity. Clin Sci 74:331-334, 1988
40. Feldman RD, Limbird L, Nadeau J, et al: Alterations in leukocyte β-receptor affinity with aging. N Engl J Med 310: 815-819, 1984
41. Poehlman E, McAuliffe T, Danforth E: Effects of age and level of physical activity on plasma norepinephrine kinetics. Am J Physiol 258:E256-E262,1990
42. Kiecolt-Glaser JK, Marucha PT, Malarkey WB, et al: Slowing of wound healing by psychological stress. Lancet 346(8984): 1194-1196, 1995