Clinical role for a superantigen in Yersinia pseudotuberculosis infection

Journal of Clinical Investigation

Volumn 99, Issue 8, 1997, Pages 1823-1830

  Abe, Jun ^a   Onimaru, Michiko ^a   Matsumoto, Shinichi ^b   Noma, Seiji ^c   Baba, Kiyoshi ^d   Ito, Yasuhiko ^a   Kohsaka, Takao ^a   Takeda, Tae ^a  

^a NATIONAL CHILDREN S HOSPITAL   (Japan)

^b Yamaga Municipal Hospital   (Japan)

^c Hachioji Metropol Children's Hosp   (Japan)

^d KURASHIKI CENTRAL HOSPITAL   (Japan)

Author keywords

arthritis; enzyme linked immunosorbent assay; Kawasaki syndrome; polymerase chain reaction; T cells

Indexed keywords

SUPERANTIGEN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ADOLESCENT; ADULT; ANTIBODY TITER; ARTHRITIS; ARTICLE; BACTERIAL GENE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GRAM NEGATIVE INFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY DISEASE; LYMPHADENOPATHY; MALE; MESENTERY LYMPH NODE; MUCOCUTANEOUS LYMPH NODE SYNDROME; PRIORITY JOURNAL; T LYMPHOCYTE; YERSINIA PSEUDOTUBERCULOSIS;

EID: 0030960753     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119349     Document Type: Article

References (63)

1. Knapp, W. 1958. Mesenteric adenitis due to Pasteurella pseudotuberculosis in young people. N. Engl. J. Med. 259:776-778.
2. Winblad, S., B. Nillehn, and N.H. Sternby. 1966. Yersinia enterocolitica (Pasteurella X) in human enteric infections. Br. Med. J. 2:1363-1366.
3. Krober, M.S., J.W. Bass, and P.J. Barcia. 1983. Scarlatiniform rash and pleural effusion in a patient with Yersinia pseudotuberculosis infection. J. Pediatr. 102:879-881.
4. Leino, R., A.L. Makela, A. Tiilikainen, and A. Toivanen. 1980. Yersinia arthritis in children. Scand. J. Rheumatol. 9:245-249.
5. Tertti, R., K. Granfors, O.P. Lehtonen, J. Mertsola, A.L. Makela, I. Valimaki, P. Hanninen, and A. Toivanen. 1984. An outbreak of Yersinia pseudotuberculosis infection. J. Infect. Dis. 149:245-250.
6. Saari, K.M., M. Maki, T. Paivonsalo, R. Leino, and A. Toivanen. 1986. Acute anterior uveitis and conjunctivitis following Yersinia infection in children. Int. Ophthalmol. 9:237-241.
7. Baba, K., N. Takeda, and M. Tanaka. 1991. Cases of Yersinia pseudotuberculosis infection having diagnostic criteria of Kawasaki disease. Contrib. Microbiol. Immunol. 12:292-296.
8. Davenport, A., B. O'Connor, and R. Finn. 1987. Acute renal failure following Yersinia pseudotuberculosis septicaemia. Postgrad. Med. J. 63:815-816.
9. Une, T. 1977. Studies on the pathogenicity of Yersinia enterocolitica. III. Comparative studies between Y. enterocolitica and Y. pseudotuberculosis. Microbiol. Immunol. 21:505-516.
10. El-Maraghi, N.R.H., and N.S. Mair. 1979. The histopathology of enteric infection with Yersinia pseudotuberculosis. Am. J. Clin. Pathol. 71:631-639.
11. Abe, J., T. Takeda, Y. Watanabe, H. Nakao, N. Kobayashi, D.Y.M. Leung, and T. Kohsaka. 1993. Evidence for superantigen production by Yersinia pseudotuberculosis. J. Immunol. 151:4183-4188.
12. Uchiyama, T., A.T. Miyoshi, H. Kato, W. Fujimaki, K. Imanishi, and X.J. Yan. 1993. Superantigenic properties of a novel mitogenic substance produced by Yersinia pseudotuberculosis isolated from patients manifesting acute and systemic symptoms. J. Immunol. 151:4407-4413.
13. White, J., A. Herman, A.M. Pullen, R. Kubo, J.W. Kappler, and P. Marrack. 1989. The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell. 56:27-35.
14. Kappler, J., B. Kotzin, L. Herron, E.W. Gelfand, R.D. Bigler, A. Boylston, S. Carrel, D.N. Posnett, Y. Choi, and P. Marrack. 1989. Vβ-specific stimulation of human T cells by staphylococcal toxins. Science (Wash. DC). 244:811-813.
15. Fleischer, B. 1989. A conserved mechanism of T lymphocyte stimulation by microbial exotoxins. Microbiol. Pathol. 7:79-83.
16. Marrack, P., and J. Kappler. 1990. The staphylococcal enterotoxins and their relatives. Science (Wash. DC). 248:705-711.
17. Jardetzky, T.S., J.H. Brown, J.C. Gorga, L.J. Stern, R.G. Urban, Y. Chi, C. Stauffacher, J.L. Strominger, and D.C. Wiley. 1994. Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen. Nature (Lond.). 368:711-718.
18. + T cells in mice tolerant to Staphylococcus aureus enterotoxin B. Nature (Lond.). 349:245-248.
19. O'Hehir, R.E., and J.R. Lamb. 1990. Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins. Proc. Natl. Acad. Sci. USA. 87:8884-8888.
20. Ito, Y., J. Abe, K. Yoshino, T. Takeda, and T. Kohsaka. 1995. Sequence analysis of the gene for a novel superantigen produced by Yersinia pseudotuberculosis and expression of the recombinant protein. J. Immunol. 154:5896-5906.
21. Yoshino, K., T. Ramamurthy, G.B. Nair, H. Fukushima, Y. Ohtomo, N. Takeda, S. Kaneko, and T. Takeda. 1995. Geographical heterogeneity between Far East and Europe in prevalence of ypm gene encoding the novel superantigen among Yersinia pseudotuberculosis strains. J. Clin. Microbiol. 33:3356-3358.
22. Carniel, E., and H.H. Mollarat. 1990. Yersiniosis. Comp. Immun. Microbiol. Infect. Dis. 13:51-58.
23. Sato, K., K. Ouchi, and M. Taki. 1983. Yersinia pseudotuberculosis infection in children, resembling Izumi fever and Kawasaki syndrome. Pediatr. Infect. Dis. 2:123-126.
24. Inoue, M., H. Nakashima, O. Ueba, T. Ishiba, H. Date, S. Kobashi, K. Takagi, T. Nishu, and M. Tsubokura. 1984. Community outbreak of Yersinia pseudotuberculosis. Contrib. Microbiol. Immunol. 28:883-891.
25. Somov, G.P., and I.L. Martinevsky. 1973. New facts about pseudotuberculosis in the USSR. Contrib. Microbiol. Immunol. 2:214-216.
26. Maina, C.V., P.D. Riggs, A.G. Grandea III, B.E. Slatko, L.S. Moran, J.A. Tagliamonte, L.A. McReynolds, and C. Guan. 1988. A vector to express and purify foreign proteins in Escherichia coli by fusion to, and separation from, maltose binding protein. Gene. 74:365-373.
27. Leung, D.Y.M., R. Harbeck, P. Bina, R.F. Reiser, E. Yang, D.A. Norris, J.M. Hanifin, and H.A. Sampson. 1993. Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. J. Clin. Invest. 92:1374-1380.
28. Choi, Y., B. Kotzin, L. Herron, J. Callahan, P. Marrack, and J. Kappler. 1989. Interaction of Staphylococcus aureus toxin "superantigens" with human T cells. Prac. Natl. Acad. Sci. USA. 86:8941-8945.
29. Robinson, M.A. 1991. The human T cells receptor β-chain gene complex contains at least 57 variable gene segments. Identification of six Vβ genes in four new gene families. J. Immunol. 146:4392-4397.
30. D. Balk, S.P., E.C. Ebert, R.L. Blumenthal, F.V. McDermott, K.W. Wucherpfennig, S.B. Landau, and R.S. Blumberg. 1991. Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes. Science (Wash. DC). 253:1411-1415.
31. Kerckhove, C.V., G.J. Russell, K. Deusch, K. Reich, A.K. Bhan, H. DerSimonian, and M.B. Brenner. 1992. Oligoclonality of human intestinal intraepithelial T cells. J. Exp. Med. 175:57-63.
32. Blumberg, R.S., C.E. Yockey, G.G. Gross, E.C. Ebert, and S.P. Balk. 1993. Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones that utilize multiple Vβ T cell receptor genes. J. Immunol. 150:5144-5153.
33. Gross, G.G., V.L. Schwartz, C. Stevens, E.C. Ebert, R.S. Blumberg, and S.P. Balk. 1994. Distribution of dominant T cell receptor β chains in human intestinal mucosa. J. Exp. Med. 180:1337-1344.
34. Cornelis, G., Y. Laroche, G. Balligand, M.P. Sory, and G. Wauters. 1987. Yersinia enterocolitica, a primary model for bacterial invasiveness. Rev. Infec. Dis. 9:64-87.
35. Brubaker, R.R. 1991. Factors promoting acute and chronic diseases caused by Yersiniae. Clin. Microbiol. Rev. 4:309-324.
36. Isberg, R.R., and S. Falkow. 1985. A single genetic locus encoded by Yersinia pseudotuberculosis permits invasion of cultured animal cells by Escherichia coli K-12. Nature (Lond.). 317:262-264.
37. Bolin, I., and W.H. Wolf. 1988. The plasmid-encoded Yop2b protein of Yersinia pseudotuberculosis is a virulence determinant regulated by calcium and temperature at the level of transcription. Mol. Microbiol. 22:237-245.
38. Rosqvist, R., A. Forsberg, M. Rimpilainen, T. Bergman, and H. Wolf-Watz. 1990. The cytotoxic protein YopE of Yersinia obstructs the primary host defense. Mol. Microbiol. 4:657-667.
39. Bliska, J.B., K. Guan, J.E. Dixon, and S. Falkow. 1991. Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant. Proc. Natl. Acad. Sci. USA. 88:1187-1191.
40. Rosqvist, R., K.E. Magnusson, and W.H. Wolf. 1994. Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells. EMBO (Eur. Mol. Biol. Organ.) J. 13:964-972.
41. Bohach, G.A., D.J. Fast, R.D. Nelson, and P.M. Schlievert. 1990. Staphylococcal and streptococcal pyrogenic toxins involved in toxic shock syndrome and related illnesses. Crit. Rev. Microbiol. 17:251-272.
42. Kotzin, B.L., D.Y.M. Leung, J. Kappler, and P. Marrack. 1993. Superantigen and their potential role in human disease. Adv. Immunol. 54:99-166.
43. Miethke, T., C. Wahl, D. Regele, H. Gaus, K. Heeg, and H. Wagner. 1993. Superantigen mediated shock: a cytokine release syndrome. Immunobiol. 189:270-284.
44. Kotb, M. 1995. Bacterial pyrogenic exotoxins as superantigens. Clin. Microbiol. Rev. 8:411-426.
45. Takei, S., Y.K. Arora, and S.M. Walker. 1993. Intravenous immunoglobulin contains specific antibodies inhibitory to activation of T cells by staphylococcal toxin superantigens. J. Clin. Invest. 91:602-607.
46. Fukami, T. 1986. Frequency of Yersinia species isolated from sporadic patients with diarrhea (in Japanese). Media Circle. 31:314-318.
47. Choi, Y., J.A. Lafferly, J.R. Clements, J.K., Todd, E.W. Gelfand, J. Kappler, P. Marrack, and B.L. Kotzin. 1990. Selective expansion of T cells expressing Vβ2 in toxic shock syndrome. J. Exp. Med. 172:981-984.
48. Watanabe-Ohnishi, R., D.E. Low, A. McGeer, D.L. Steevens, P.M. Schlievert, D. Newton, B. Schwarz, B. Kreiswirth, and M. Kotb. 1995. Selective depletion of Vb-bearing T cells in patients with severe invasive group A streptococcal infections and streptococcal toxic shock syndrome. J. Infect. Dis. 171: 74-84.
49. Wahl, C., T. Miethke, K. Heeg, and H. Wagner. 1993. Clonal deletion as direct consequence of an in vivo T cell response to bacterial superantigen. Eur. J. Immunol. 23:1197-1200.
50. McCormack, J.E., J.E. Callahan, J. Kappler, and P.C. Marrack. 1993. Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen. J. Immunol. 150:3785-3792.
51. Blaser, M.J., R.A. Miller, J. Lacher, and J.W. Singleton. 1984. Patients with active Crohn's disease have elevated serum antibodies to antigens of seven enteric bacterial pathogens. Gastroenterology. 87:888-894.
52. Treacher, D.F., and D.P. Jewell. 1985. Yersinia colitis associated with Crohn's disease. Postgrad. Med. J. 61:173-174.
53. Granfors, K., S. Jalkanen, R. Von Essen, R.R. Lahesmaa, O. Isomaki, H.K. Pekkola, P.R. Merilahti, R. Saario, H. Isomaki, and A. Toivanen. 1989. Yersinia antigens in synovial fluid cells from patients with reactive arthritis. N. Engl. J. Med. 320:216-221.
54. Hammer, M., H. Zeidler, S. Klimsa, and J. Heesemann. 1990. Yersinia enterocolitica in the synovial membrane of patients with Yersinia-induced arthritis. Arthritis Rheum. 33:1795-1801.
55. Life, P.F., N.J. Viner, P.A. Bacon, and J.S. Gaston. 1990. Synovial fluid antigen-presenting cells unmask peripheral blood T cell responses to bacterial antigens in inflammatory arthritis. Clin. Exp. Immunol. 79:189-194.
56. Hermann, E., A.W. Lohse, d.Z.R. Van, E.W. Van, W.J. Mayet, P. Probst, T. Poralla, z.B.K. Meyer, and B. Fleischer. 1991. Synovial fluid-derived Yersinia-reactive T cells responding to human 65-kDa heat-shock protein and heat-stressed antigen-presenting cells. Eur. J. Immunol. 21:2139-2143.
57. Probst, P., E. Hermann, z.K.B. Meyer, and B. Fleischer. 1993. Multi-clonal synovial T cell response to Yersinia enterocolitica in reactive arthritis: the Yersinia 61-kDa heat-shock protein is not the major target antigen. J. Infect. Dis. 167:385-391.
58. Lahesmaa, R., H. Yssel, S. Batsford, R. Luukkainen, T. Mottonen, L. Steinman, and G. Peltz. 1992. Yersinia enterocolitica activates a T helper type 1-like T cell subset in reactive arthritis. J. Immunol. 148:3079-3085.
59. Hermann, E., D.T. Yu, z.K.B. Meyer, and B. Fleischer. 1993. HLA-B27-restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis. Lancet (N. Am. Ed.). 342:646-650.
60. Autenrieth, I.B., U. Vogel, S. Preger, B. Heymer, and J. Heesemann. 1993. Experimental Yersinia enterocolitica infection in euthymic and T-cell-deficient athymic nude C57BL/6 mice: comparison of time course, histomorphology, and immune response. Infect. Immun. 61:2585-2595.
61. Autenrieth, I.B., M. Beer, E. Bohn, S.H. Kaufmann, and J. Heesemann. 1994. Immune responses to Yersinia enterocolitica in susceptible BALB/c and resistant C57BL/6 mice: an essential role for gamma interferon. Infect. Immun. 62:2590-2599.
62. Noll, A., A. Roggenkamp, J. Heesemann, and I.B. Autenrieth. 1994. Protective role for heat shock protein-reactive αγ T cells in murine yersiniosis. Infect. Immun. 62:2784-2791.
63. Starnbach, M.N., and M.J. Bevan. 1994. Cells infected with Yersinia present an epitope to class I MHC-restricted CTL. J. Immunol. 153:1603-1612.