Cardiorespiratory effects of L-glutamate microinjected into the rat ventral medulla

Respiration Physiology

Volumn 108, Issue 1, 1997, Pages 23-33

  Tolentino Silva, F P ^a   Campos Jr , R R ^a   Russo, A K ^a   Cravo, S L ^a   Lopes, O U ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Breathing pattern; Cardiorespiratory control; L glutamate; Rat; Ventral surface of the medulla

Indexed keywords

GLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREATHING PATTERN; BREATHING RATE; CHEMORECEPTOR; HEART RATE; LUNG MINUTE VOLUME; MALE; MEAN ARTERIAL PRESSURE; MEDULLA OBLONGATA; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATION CONTROL; SURGICAL ANATOMY; TIDAL VOLUME;

EID: 0030960322     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5687(97)02530-9     Document Type: Article

References (26)

1. Aoki, M., S. Mori, K. Kawahara, H. Watanabe and N. Ebata (1980). Generation of spontaneous respiratory rhythm in high spinal cats. Brain Res. 202: 51-63.
2. Baradzief, S. and A. Trzebski (1989). Specific areas of the ventral medulla controlling sympathetic and respiratory activities and their functional synchronization in the rat. In: The Central Neural Organization of Cardiovascular Control, Vol. 81, edited by J. Ciriello, M.M. Caversom and C. Polosa. Elsevier, New York, pp. 193-204.
3. Bonham, A. and I. Jeske (1989). Cardiorespiratory effects of DL-homocysteic acid in caudal ventrolateral medulla. Am. J. Physiol. 256: H688-H696.
4. Bruce, E.N. and N.S. Cherniack (1987). Central chemoceptors. J. Appl. Physiol. 62: 389-402.
5. Campos, R.R. Jr., O.S. Possas, S.L. Cravo, O.U. Lopes and P.G. Guertzenstein (1994). Putative pathways involved in cardiovascular responses evoked from the caudal pressor area. Brazilian J. Med. Biol. Res. 27: 2467-2479.
6. Coates, E.L., A. Li and E.E. Nattie (1993). Widespread sites of brain stem ventilatory chemoreceptors. J. Appl. Physiol. 75: 5-14.
7. Cravo, S.L., S.F. Morrison and D.J. Reis (1991). Differentiation of two cardiovasculalr regions within the caudal ventrolateral medulla. Am. J. Physiol. 261: R985-R994.
8. Ellenberger, H.H., J.L. Feldman and W.Z. Zhan (1990). Subnuclear organization of the lateral tegmental field of the rat. II: catecholamine neurons and ventral respiratory group. J. Comp. Neurol. 294: 212-222.
9. Feldberg, W. and P.G. Guertzenstein (1976). Vasodepressor effects obtained by drugs acting on the ventral surface of the brain stem. J. Physiol. (London) 258: 337-55.
10. Gordon, F.J. and L.A. McCann (1988). Pressor responses evoked by microinjections of L-glutamate into caudal ventrolateral medulla of the rats. Brain Res. 457: 251-258.
11. Guertzenstein, P.G. and A. Silver (1974). Fall in blood pressure produced from discrete regions of the ventral surface medulla by glycine and lesions. J. Physiol. (London) 242: 489-503.
12. Guyenet, P.G., R.A. Darnall and T.A. Riley (1990). Rostral ventrolateral medulla and sympathorespiratory integration in rats. Am. J. Physiol. 259: R1063-R1074.
13. Kuwaki, T., W.H. Cao, M. Yamamoto, N. Terui and M. Kumada (1991). Cardiorespiratory effects of topical application of endothelin-1 to the ventral surface of the rat medulla. J. Cardiovasc. Pharmacol. 17: S343-345.
14. Lipski, J. and E.G. Merrill (1980). Electrophysiological demonstration of the projection from expiratory neurons in the rostral medulla to contralateral dorsal respiratory group. Brain Res. 197: 521-524.
15. Mitra, J., N.R. Prabhakar, J.L. Overholt and N.S. Cherniack (1988). Respiratory and vasomotor responses to focal cooling of the ventral medullary surface (V.M.S.) of the rat. Respir. Physiol. 74: 35-48.
16. 1 adrenergic cell group. J. Neurosci. 8: 1286-1301.
17. 2-sensitive phrenic and sympathetic output. J. Appl. Physiol. 74: 2958-2968.
18. 2 sensitivity in rats. Respir. Physiol. 97: 63-77.
19. Onimaru, H., A. Arata and I. Homma (1989). Firing properties of respiratory rhythm generating neurons in the absence of synaptic transmission in rat medulla in vitro. Exp. Brain Res. 76: 530-536.
20. Paxinos, G. and C. Watson (1986). The Rat Brain in Stereotaxic Coordinates. Orlando, FL: Academic Press.
21. Possas, O.S., R.R. Campos Jr., S.L. Cravo, O.U. Lopes and P.G. Guertzenstein (1994). A fall in arterial blood pressure produced by inhibition of the caudalmost ventrolateral medulla: the caudal pressor area. J. Auton. Nerv. Syst. 49: 235-245.
22. Schlaefke, M.E. (1981). Central chemosensitivity: a respiratory drive. Rev. Physiol. Biochem. Pharmacol. 90: 171-244.
23. Silva, F.R.P.T., R.R. Campos Jr., E. Freire, P.G. Guertzenstein, I.C. Piçarro, L.O.C. Rodrigues, A.K. Russo, A.C. Silva and J. Tarasantchi (1989). Breathing pattern during pharmacological activation and blockade of the intermediate area of the ventrolateral surface of the cat medulla. Brazilian J. Med. Biol. Res. 22: 1527-1530.
24. Smith, J.C., D.E. Morrison, H.H. Ellenberger, M. R. Otto and J.L. Feldman (1989). Brainstem projections to the major respiratory neuron populations in the medulla of the cat. J. Comp. Neurol. 281: 69-96.
25. Tolentino-Silva, F.P., R.R. Campos, A.K. Russo, A.C. Silva, E. Freire and P.G. Guertzenstein (1993). Cardiorespiratory alterations produced by pharmacological agents applied to the ventrolateral medulla (intermediate area) of the cat. Effect of exercise condition on glycine-induced inhibition. Brazilian J. Med. Biol. Res. 26: 879-896.
26. von Euler, C. (1986). Brain-stem mechanisms for generation and control of breathing. In: Handbook of Physiology, Section 3: The Respiratory System, Vol. II: Control of Breathing, part 1, edited by N.S. Cherniack and J.G. Widdicombe. Washington, D.C.: American Physiological Society, pp. 1-68.