Differential activation of the epithelial and smooth muscle NK1 receptors by synthetic tachykinin agonists in guinea-pig trachea

British Journal of Pharmacology

Volumn 121, Issue 4, 1997, Pages 773-781

  Figini, Michela ^a   Emanueli, Costanza ^a   Bertrand, Claude ^b   Sicuteri, Riccardo ^c   Regoli, Domenico ^a   Geppetti, Pierangelo ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b ROCHE BIOSCIENCE   (United States)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Airway; Epithelium; NK1 receptors; Septide; Substance P; Tachykinins

Indexed keywords

ACETYLCHOLINE; INDOMETACIN; N(G) METHYLARGININE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR AGONIST; NEUROKININ 2 RECEPTOR ANTAGONIST; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHORAMIDON; SAREDUTANT; SUBSTANCE P; SUBSTANCE P DERIVATIVE; TACHYKININ RECEPTOR AGONIST;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENANTIOMER; EPITHELIUM CELL; GUINEA PIG; MALE; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SMOOTH MUSCLE FIBER; TRACHEA MUCOSA; TRACHEA MUSCLE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIUM; GUINEA PIGS; MALE; MUSCLE, SMOOTH; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; PEPTIDE FRAGMENTS; PHYSALAEMIN; PIPERIDINES; PYRROLIDONECARBOXYLIC ACID; QUINUCLIDINES; RECEPTORS, NEUROKININ-1; SUBSTANCE P; TACHYKININS; TRACHEA;

EID: 0030960118     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701188     Document Type: Article

References (25)

1. BALLATI, L., EVANGELISTA, S., MAGGI, C.A. & MANZINI, S. (1992). Effects of selective tachykinin receptor antagonists on capsaicin-and tachykinin-induced bronchospasm in anaesthetized guinea-pigs. Eur. J. Pharmacol., 214, 215-221.
2. BEAUJOUAN, J.C., TEUTSCH, B., SAFFROY, M., PETITET, F., TORRENS, Y. & GLOWINSKI, J. (1992). NK-1 receptors are the only class of tachykinin receptors found on mouse cortical astrocytes. Peptides, 12, 813-820.
3. BERTRAND, C., NADEL, J.A., GRAF, P.D. & GEPPETTI, P. (1993). Capsaicin increases airflow resistance in guinea pigs in vivo by activating both NK2 and NK1 tachykinin receptors. Am. Rev. Respir. Dis., 148, 909-914.
4. 9] SP(6-11) interact with two different receptors in the guinea-pig ileum as demonstrated with new substance P antagonists. Neuropeptides, 23, 73-79.
5. 3 receptor. Life Sci., 56, 27-32.
6. 1) receptor. Neuropeptides, 24, 231-239.
7. EMONDS-ALT, X., VILAIN, P., GOULAOULIC, P., PROIETTO, V., VAN BROECK, D., ADVENIER, C., NALINE, E., NELIAT, G., LE FUR, G. & BRELIERE, J.C. (1992). A potent and selective non peptide antagonist of the neurokinin A (NK-2) receptor. Life Sci., 50, 101-106.
8. 1 receptor. Br. J. Pharmacol., 115, 128-132.
9. FROSSARD, N., RHODEN, K.J. & BARNES, P.J. (1989). Influence of epithelium on guinea pig airway responses to tachykinins: role of endopeptidase and cyclooxygenase. J. Pharmacol. Exp. Ther., 248, 292-298.
10. GLOWINSKI, J. (1995). The 'septide-sensitive' tachykinin receptor: still an enigma. Trends Pharmacol. Sci., 16, 365-367.
11. 1 receptor antagonist. Br. J. Pharmacol., 102, 168P.
12. 1 tachykinin receptor characteristics in the rabbit isolated iris sphincter. Br. J. Pharmacol., 112, 985-991.
13. KENAKIN, T. (1995). Agonist-receptor efficacy: agonist trafficking of receptor signals. Trends Pharmacol. Sci., 16, 232-238.
14. LONGMORE, J., RAZZAQUE, Z., SHAW, D. & HILL, R.G. (1994). Differences in the effects of NK1-receptor antagonists, (±)-CP-96,345 and CP-99,994, on agonist-induced responses in guinea-pig trachea. Br. J. Pharmacol., 112, 176-178.
15. MAGGI, C.A., PATACCHINI, R., MEINI, S. & GIULIANI, S. (1993a). Evidence for the presence of septide-sensitive tachykinin receptor in the circular muscle of the guinea-pig ileum. Eur. J. Pharmacol., 235, 309-311.
16. MAGGI, C.A., PATACCHINI, R., ROVERO, P. & GIACHETTI, A. (1993b). Tachykinin receptors and tachykinin receptor antagonists. J. Auton. Pharmacol., 13, 23-93.
17. 1 receptor subtypes in the rat urinary bladder. Br. J. Pharmacol., 111, 739-746.
18. NADEL, J. (1991). Neutral endopeptidase modulates neurogenic inflammation. Eur. Respir. J., 4, 745-754.
19. NIJKAMP, P.P., VAN DER LINDE, H.J. & FOLKERTS, G. (1993). Nitric oxide synthesis inhibitors induce airway hyperresponsiveness in the guinea pig in vivo and in vitro. Role of the epithelium. Am. Rev. Respir. Dis., 148, 727-734.
20. PETITET, F., SAFFROY, M., TORRENS, Y. LAVIELLE, S., CHASSAING, G., LOEUILLET, D., GLOWINSKI, J. & BEAUJOUAN, J.-C. (1992). Possible existence of a new tachykinin receptor subtype in the guinea-pig ileum. Peptides, 13, 383-388.
21. PRADIER, L., MENAGER, J., LE GUERN, J., BOCK, M.D., HEUILLET, E., FARDIN, V., GARET, C., DOBLE, A. & MAYAUX, J.-F. (1994). Septide: an agonist for the NK1 receptor acting at a site distinct from substance P. Mol. Pharmacol., 45, 287-293.
22. REGOLI, D., BOUDON, A. & FAUCHERE, J.-L. (1994). Receptors and antagonists for substance P and related peptides. Pharmacol. Rev., 46, 551-599.
23. SAGAN, S., CHASSAING, G., PRADIER, L. & LAVIELLE, S. (1996). Tachykinin peptides affect differently the second messenger pathways after binding to CHO-expressed human NK1 receptors. J. Pharmacol. Exp. Ther., 276, 1039-1048.
24. SPENGLER, D., WAEBER, C., PANTALONI, C., HOLSBOER, F., BOCKAERT, J., SEEBURG, P.H. & JOURNOT, L. (1993). Differential signal transduction by five splice variants of the PACAP receptor. Nature, 365, 170-175.
25. ZENG, X.-P. & BURCHER, E. (1994). Use of selective antagonists for further characterization of tachykinin NK-2, NK-1 and possible "septide-selective" receptors in guinea-pig bronchus. J. Pharmacol. Exp. Ther., 270, 1295-1300.