An extract of the fern Polypodium leucotomos inhibits human peripheral blood mononuclear cells proliferation in vitro

International Journal of Immunopharmacology

Volumn 19, Issue 1, 1997, Pages 9-14

  Rayward, Jennifer ^a   Villarrubia, Vicente G ^b   Guillen, Cristina ^a   Prieto, Alfredo ^a   Rodriguez Zapata, Manuel ^a   Sada, Guillermo ^b   Alvarez Mon, Melchor ^a,c  

^a Division de Inmunologia   (Spain)

^b AUTONOMOUS UNIVERSITY OF MADRID   (Spain)

^c UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

Polypodium leucotomos extract; T specific immunosuppression

Indexed keywords

ALCOHOL; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2 RECEPTOR; MITOGENIC AGENT; MONOCLONAL ANTIBODY CD3; PHORBOL ESTER; PHYTOHEMAGGLUTININ; PLANT EXTRACT; POLYPODIUM LEUCOTOMOS EXTRACT; RECOMBINANT INTERLEUKIN 2; UNCLASSIFIED DRUG;

ADULT; ALPHA CHAIN; ARTICLE; AUTOIMMUNITY; BLOOD; CONTROLLED STUDY; CULTURE MEDIUM; DOSE TIME EFFECT RELATION; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MALE; MONONUCLEAR CELL; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; ANTIGENS, CD; FEMALE; HLA-DR ANTIGENS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MALE; MITOGENS; MUROMONAB-CD3; PHYTOHEMAGGLUTININS; PLANT EXTRACTS; PLANT LECTINS; PLANTS, MEDICINAL; T-LYMPHOCYTES;

EID: 0030959949     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(97)00002-7     Document Type: Article

References (15)

1. Altman, A., Coggeshall, K. M. & Mustelin, T. (1990) Molecular events mediating T cell activation. Adv. Immunol., 48, 227-360.
2. Arai, K., Lee, F., Miyajima, A., Miyatake, S., Arai, N. & Yokota, T. (1990) Cytokines: coordinators of immune and inflammatory responses. Annu. Rev. Biochem., 59, 783-836.
3. Capella-Pérez, M. C. & Castells Rodellas, A. (1981) Double blind study of Polypodium leucotomos (120 mg/kg) in the treatment of psoriasis. Act Dermosifilograf., 72, 487-494.
4. Corrales, H., Pathak, M.A., Fitzpatrick, T.B. & González, S. (1994) The use of oral and topical Polypodium Leucotomos in the therapy of vitiligo. Congress of the American Academy of Dermatology.
5. Depper, J. M., Leonard, W. J., Drogula, C., Kronke, M., Waldmann, T. A. & Greene, W. C. (1985) Interleukin-2 (IL-2) augments transcription of the IL-2 receptor gene. Proc. Natl. Acad. Sci. USA., XX, 4230-4234.
6. - natural killer cell subset. Blood, 82, 1538-1545.
7. Hadden, J. W. (1988) Transmembrane signals in the activation of T-lymphocytes by lectin mitogens. Mol. Immunol., 25, 1105-1112.
8. Jiménez, D., Doblars, E., Naranjo, R., Mũoz, C. & Vargas, J. F. (1986) Anapsos modifies immunological parameters and improves the clinical course in atopic dermatitis. Dermatologika, 173, 154-156.
9. Manger, B., Weiss, A., Weyand, C., Goronzy, J. & Stobo, J. D. (1985) T cell activation: differences in the signals required for IL-2 production by non activated and activated T cells. J. Immunol., 135, 3669-3673.
10. Mohammad, A. (1989) Vitiligo repigmentation with anapsos (Polypodium leucotomos). Int. J. Dermatol., 28, 479.
11. Sigal, N. H. & Dumont, F. J. (1992) Cyclosporin A, FK-506, and Rapamycin: Pharmacologic probes of lymphocyte signal transduction. Annu. Rev. Immunol., 10, 519-560.
12. Truneh, A., Albert, F., Goldstein, P., Schmitt-Verhulst, A. M. (1985) Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester. Nature, 313, 318-320.
13. Tuominen, M., Bohlin, L., Lindbom, L. O. & Rolfsen, W. (1991) Enhancing effect of Calaguala on the prevention of rejection on skin transplants in mice. Phytother. Res., 5, 234-236.
14. Tuominen, M., Bohlin, L. & Rolfsen, W. (1992) Effects of Calaguala and an active principle, adenosine, on platelet activating factor. Planta Med., 58, 306-311.
15. Vargas, J., Muñoz, C., Osorio, C. & Garcia-Olivares, E. (1983) Anapsos, an antipsoriatic drug wich increases the proportion of suppressor cells in human peripheral blood. Ann Immunol. (Inst. Pasteur), 134c, 393-400.