Pharmacokinetics of topically applied metronidazole in two different formulations

Skin Pharmacology and Physiology

Volumn 10, Issue 1, 1997, Pages 28-33

  Dykes, Peter ^a   Hill, Stephanie ^a   Marks, Ronald ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Cutaneous levels; Metronidazole; Percutaneous absorption; Topical formulations; Volunteer study

Indexed keywords

2 PHENOXYETHANOL; BRONOPOL; EXCIPIENT; HYDROXYETHYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; METRONIDAZOLE; PROPYLENE GLYCOL; THICKENING AGENT; WATER;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG PENETRATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PUNCH BIOPSY; RANDOMIZED CONTROLLED TRIAL; ROSACEA; SKIN BIOPSY; SKIN PENETRATION; STATISTICAL ANALYSIS; STRATUM CORNEUM; TOPICAL DRUG ADMINISTRATION;

EID: 0030959534     PISSN: 16605527     EISSN: 16605535     Source Type: Journal    
DOI: 10.1159/000211457     Document Type: Article

References (19)

1. Saihan EM, Burton JL: A double blind trial of metronidazole vs Oxytetracycline therapy for rosacea. Br J Dermatol 1980;102:443-445.
2. Gamborg Nielsen P: Treatment of rosacea with 1% metronidazole cream: A double blind study. Br J Dermatol 1983;108:327-332.
3. Bleicher PA, Charles JH, Sober AJ: Topical metronidazole therapy for rosacea. Arch Dermatol 1987; 123: 609-614.
4. Schmadel LK, McEvoy GK: Topical metronidazole: A new therapy for rosacea. Clin Pharm 1990,9:94-101.
5. Poelman MC, Leveque JL: Influence of the vehicle on the efficacy of anti-inflammatory drugs measured by non invasive methods; in Brain KR, James VJ, Walters KA (cds): Prediction of Percutaneous Penetration. Cardiff, STS Publishing, 1993, vol 3b, pp 299-302.
6. Hadgraft J: Skin penetration enhancement; in Brain KR, James VJ, Walters KA (eds): Prediction of Percutaneous Penetration. Cardiff, STS Publishing, 1993, vol 3b, pp 138-148.
7. Marks R, Dykes PJ: Plasma and cutaneous levels after topical application of piroxicam gel: A study in healthy volunteers. Skin Pharmacol 1994;7:340-344.
8. Marks R, Dawbcr RPR: Skin surface biopsy: An improved technique for the examination of the horny layer. Br J Dermatol 1971;84:117-123.
9. Jensen JC, Guglcr R: Sensitive high performance liquid chromatographic method for the determination of metronidazole and metabolites. J Chromatogr 1983;277:381-384.
10. Meier PC, Ziind RE: Statistical Methods in Analytical Chemistry. New York, Wiley & Sons, 1993.
11. Tan CY, Statham B, Marks R, Payne PA: Skin thickness measurement by pulsed ultrasound: Its reproducibility, validation and variability. Br J Dermatol 1982; 106: 657-667.
12. Dykes PJ, Thomas R, Marks R: The pharmacokinetics of topically applied terbinafine: Results from studies in healthy volunteer subjects and patients with pityriasis versicolor. J Dermatol Treat 1990; 1 (suppl 2): 19-21.
13. Dykes PJ, Marks R, Tauber U: The retention of isoconazole in the skin after once or twice daily application of 1% isoconazole nitrate cream over a 14 day period. Clin Exp Dermatol 1986;11:365-370.
14. Watson WS, Finlay AY: The effect of vehicle formulation on the stratum comcum penetration characteristics of clobetasol 17-propionate in vivo. Br J Dermatol 1988; 118:523-530.
15. Hilton J, Woollen BH, Scott RC, Auton TR, Trebilcock KL, Wilks MF: Vehicle effects on in vitro percutaneous absorption through rat and human skin. Pharm Res 1994; 11:1396-1400.
16. Liu CH, Ho HO, Hsieh MC, Soko-loski TD, Shue MT: Studies on the in vitro percutaneous penetration of indomethacin from gel systems in hairless mice. J Pharm Pharmacol 1995;47:365-372.
17. Patel RA, Vasavada RC: Transder-mal delivery of isoproterenol HC1: An investigation of stability, solubility, partition coefficient and vehicle effects. Pharm Res 1988;5:116-119.
18. Lahti A, Poutiainen AM, Hannukse-la M: Alcohol vehicles in tests for nonimmunological immediate contact reactions. Contact Dermatitis 1993;29:22-25.
19. Goldsmith LA, Baden HP: Propylene glycol with occlusion for the treatment for ichthyosis. JAMA 1972;220:579-580.