Involvement of calyculin A inhibitable protein phosphatases in the cyclic AMP signal transduction pathway of mouse corticotroph tumour (AtT20) cells

British Journal of Pharmacology

Volumn 121, Issue 5, 1997, Pages 991-999

  Antaraki, A ^a,b   Ang, K L ^a   Antoni, F A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Calyculin A; Corticotrophin releasing factor; Cyclic AMP; FK506; G proteins; Okadaic acid; Phosphodiesterase; Pituitary tumour; Protein phosphatase; Rolipram

Indexed keywords

ADENOSINE DIPHOSPHATE; CALCIUM ION; CALYCULIN A; CHOLERA TOXIN; CORTICOTROPIN RELEASING FACTOR; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; GUANINE NUCLEOTIDE BINDING PROTEIN; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; ISOBUTYLMETHYLXANTHINE; ISOPRENALINE; OKADAIC ACID; PERTUSSIS TOXIN; PHOSPHOPROTEIN PHOSPHATASE; ROLIPRAM;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL FREE SYSTEM; CELL MEMBRANE; CELL SECRETION; CONTROLLED STUDY; ENZYME ACTIVITY; HYPOPHYSIS TUMOR; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RADIOMETRY; SIGNAL TRANSDUCTION;

2',3'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; ADENYLATE CYCLASE TOXIN; ADRENOCORTICOTROPIC HORMONE; ANIMALS; CHOLERA TOXIN; CYCLIC AMP; ENZYME ACTIVATION; ENZYME INHIBITORS; FORSKOLIN; GTP-BINDING PROTEINS; MICE; OKADAIC ACID; OXAZOLES; PERTUSSIS TOXIN; PHOSPHOPROTEIN PHOSPHATASE; PITUITARY NEOPLASMS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; VIRULENCE FACTORS, BORDETELLA;

EID: 0030958782     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701228     Document Type: Article

References (44)

1. ANG, K.L. & ANTONI, F.A. (1996). Rolipram-inhibitable cyclic nucleotide phosphodiesterase (PDE) in rat adenohypophysis: Potential functional role in corticotrophs and somatotrophs. Br. J. Pharmacol., 116, P361.
2. ANTONI, F.A. (1997). Calcium regulation of adenylyl cyclase-relevance for endocrine control. Trends Endocrinol. Metab., 8, 7-14.
3. ANTONI, F.A., BARNARD, R.J.O., SHIPSTON, M.J., SMITH, S.M., SIMPSON, J. & PATERSON, J.M. (1995). Calcineurin feedback inhibition of agonist-evoked cAMP formation. J. Biol. Chem., 270, 28055-28061.
4. APERIA, A., IBARRA, F., SVENSSON, L.-B., KLEE, C.B. & GREENGARD, P. (1992). Calcineurin mediates α-adrenergic stimulation of Na,K-ATPase activity in renal tubule cells. Proc. Natl. Acad. Sci. U.S.A., 89, 7394-7397.
5. BEAVO, J.A. & REIFSNYDER, D.H. (1990). Primary sequence of cyclic nucleotide phosphodiesterease isozymes and the design of selective inhibitors. Trends Pharmacol. Sci., 11, 150-155.
6. BELTMAN, J., SONNENBURG, W.K. & BEAVO, J.A. (1993). The role of protein phosphorylation in the regulation of cyclic nucleotide phosphodiesterases. Mol. Cell. Biochem., 127/128, 239-253.
7. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of dye-binding. Anal. Biochem., 72, 248-254.
8. BROOKER, G., HARPER, J.F., TERASAKI, W.L. & MOYLAN, R.D. (1979). Radioimmunoassay of cyclic AMP and cyclic GMP. In Advances in Cyclic Nucleotide Research, ed. Brooker, G., Greengard, P. & Robison, G.A., pp. 2-34. New York: Raven Press.
9. CHILDS, G.V., LLOYD, J., UNABIA, G. & ROUGEAU, D. (1989). Growth and secretory responses of enriched populations of corticotropes. Endocrinology, 125, 2540-2549.
10. 2-adrenergic stimulation of cAMP accumulation in S49 lymphoma cells. J. Biol. Chem., 268, 3245-3250.
11. COHEN, P. (1989). Structure and regulation of protein phosphatases. Ann. Rev. Biochem., 58, 453-508.
12. COHEN, P., HOLMES, C.F.B. & TSUKITANI, Y. (1990). Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem. Sci., 15, 98-102.
13. DUMONT, J.E., JAUNIAUX, J.-C. & ROGER, P.P. (1989). The cyclic AMP-mediated stimulation of cell proliferation. Trends Biochem. Sci., 14, 67-71.
14. GILMAN, A.G. (1987). G-proteins-transducers of receptor-generated signals. Ann. Rev. Biochem., 56, 615-649.
15. GOPALAKRISHNA, R., CHEN, Z.H. & GUNDIMEDA, U. (1992). Nonphorbol tumor promoters okadaic acid and calyculin A induce membrane translocation of protein kinase C. Biochem. Biophys. Res. Commun., 189, 950-957.
16. GOULD, K.L., BILEZIKJIAN, L.M. & HUNTER, T. (1989). AtT20 cells express modified forms of PP60c-src. Mol. Endocrinol., 3, 70-88.
17. 2-adrenergic receptors and adrenocorticotropin release. Biochem. Biophys. Res. Commun., 111, 112-119.
18. HOUSLAY, M.D. (1994). Phosphorylation of heterotrimeric G proteins. In GTPases in Biology, ed. Dickey, B.F. & Birnbaumer, L., pp. 147-165. Berlin:Springer Verlag.
19. JACOBOWITZ, O. & IYENGAR, R. (1994). Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2. Proc. Natl. Acad. Sci. U.S.A., 91, 10630-10634.
20. KAWABE, J.I., IWAMI, G., EBINE, T., OHNO, S., KATADA, T., UEDA, Y., HOMCY, C.J. & ISHIKAWA, Y. (1994). Differential activation of adenylyl cyclase by protein kinase C isozymes. J. Biol. Chem., 269, 16554-16558.
21. KLEE, C.B. & COHEN, P. (1988). The catmodulin regulated protein phosphatase, In Calmodulin. ed. Cohen, P. & Klee, C.B., pp. 225-245. Amsterdam:Elsevier.
22. KOCH, B. & LUTZ-BUCHER, B. (1994). Inhibition of protein phosphatases by okadaic acid and calyculin-A differentially modulates hormonal- and forskolin-stimulated formation of cyclic AMP in AtT20 corticotrophs: effect of pituitary adenylate cyclase activating polypeptide and corticotropin-releasing factor. Cell. Signal., 6, 467-473.
23. KOCH, B. & LUTZ-BUCHER, B. (1995). Multifactorial regulation of pituitary adenylate cyclase-activating polypeptide (PACAP)-induced production of cyclic AMP in AtT-20 corticotrophs: major involvement of rolipram-sensitive and insensitive phosphodiesterases. Mol. Cell. Endocrinol., 112, 27-34.
24. KONO, T. (1988). Insulin-sensitive cAMP phosphodiesterase in rat adipose tissue. Methods Enzymol., 159, 745-751.
25. sα and inhibition of bradykinin-induced activation of the cyclic AMP pathway in A431 cells by epidermal growth factor receptor. J. Biol. Chem., 271, 31089-31105.
26. LONGBOTTOM, D. & VAN HEYNINGEN, S. (1989). The activation of rabbit intestinal adenylate cyclase by cholera toxin, Biochim. Biophys. Acta, 1014, 289-297.
27. MANGANIELLO, V. & VAUGHAN, M. (1973). An effect of insulin on cyclic adenosine 3′:5′-monophosphate phosphodiesterase activity in fat cells. J. Biol. Chem., 248, 7164-7170.
28. MULKEY, R.M., ENDO, S., SHENOLIKAR, S. & MALENKA, R.C. (1994). Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. Nature, 369, 486-488.
29. NISHIWAKI, S., FUJIKI, H., SUGANUMA, M., FURUYA-SUGURI, H., MATSUSHIMA, R., IIDA, Y., OJIKA, M., YAMADA, K., UEMURA, T., YASUMOTO, T., SCHMITZ, F. & SUGIMURA, T. (1990). Structure-activity relationship within a series of okadaic acid derivatives. Carcinogenesis, 11, 1837-1841.
30. PATERSON, J.M., SMITH, S.M., HARMAR, A.J. & ANTONI, F.A. (1995). Control of a novel adenylyl cyclase by calcineurin. Biochem. Biophys. Res. Commun., 214, 1000-1008.
31. PITCHER, J.A., STURGIS PAYNE, E., CSORTOS, C., DEPAOLI-ROACH, A.A. & LEFKOWITZ, R.J. (1995). The G-protein-coupled receptor phosphatase: A protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity. Proc. Natl. Acad. Sci. U.S.A., 92, 8343-8347.
32. s in heterologous desensitization: a role for adenosine 3′,5′-monophosphate-dependent phosphorylation. Endocrinology, 131, 2774-2784.
33. REISINE, T. (1985). Multiple mechanisms of somatostatin inhibition of adrenocorticotropin release from mouse anterior pituitary tumor cells. Endocrinology, 116, 2259-2266.
34. ROBISHAW, J.D., SMIGEL, M.D. & GILMAN, A.G. (1986). Molecular basis for two forms of the G protein that stimulate adenylate cyclase. J. Biol. Chem., 261, 9587-9590.
35. SCHILLING, R.J., MORGAN, D.R. & KILPATRICK, B.F. (1994). A high-throughput assay for cyclic nucleotide phosphodiesterase. Anal. Biochem., 216, 154-158.
36. SETTE, C., IONA, S. & CONTI, M. (1994). The short-term activation of a rolipram-sensitive, cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation. J. Biol. Chem., 269, 9245-9252.
37. SHARMA, R.K., MOOIBROEK, M. & WANG, J.H. (1988). Calmodulin-stimulated cyclic nucleotide phosphodiesterase isozymes, In Calmodulin. ed. Cohen, P. & Klee, C.B., pp. 265-295. Amsterdam:Elsevier.
38. SHIBATA, H., ROBINSON, F.W.R.S.T. & KONO, T. (1991). Effects of okadaic acid on insulin-sensitive cAMP phosphodiesterase in rat adipocytes-evidence that insulin may stimulate the enzyme by phosphorylation. J. Biol. Chem., 266, 17948-17953.
39. SHIPSTON, M.J., HERNANDO, F., BARNARD, R.J.O. & ANTONI, F.A. (1994). Glucocorticoid negative feedback in pituitary corticotropes: pivotal role for calcineurin inhibition of adenylyl cyclase. Ann. New York Acad. Sci., 746, 453-456.
40. SIBLEY, D.R., BENOVIC, J.L., CARON, M.G. & LEFKOWITZ, R.J. (1987). Regulation of transmembrane signaling by receptor phosphorylation. Cell, 48, 913-922.
41. TOYOSHIGE, M., OKUYA, S. & REBOIS, R.V. (1994). Choleragen catalyzes ADP-ribosylation of the stimulatory G protein heterotrimer but not its free α-subunit. Biochemistry (U.S.A.), 33, 4865-4871.
42. WESTPHAL, M., JAQUET, P. & WILSON, C.B. (1986). Long-term culture of human corticotropin-secreting adenomas on extracellular matrix and evaluation of serum-free conditions. Acta Neuropathol. (Berl.), 71, 142-149.
43. WOODS, M.D., SHIPSTON, M.J., MULLENS, E.L. & ANTONI, F.A. (1992). Pituitary corticotrope tumor (AtT20) cells as a model system for the study of early inhibition by glucocorticoids. Endocrinology, 131, 2873-2880.
44. YASUMURA, Y. (1968). Retention of differentiated function in clonal animal cell lines particularly hormone-secreting cultures. Am. Zool., 8, 285-305.