Effect of polyethylene glycol conjugated to DNA-transfecting complexes targeted at the transferrin receptor of HeLa cells

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 4, Issue 2, 1997, Pages 115-119

  Robinson, Phil ^a   Hawtrey, Arthur ^a   Ariatti, Mario ^b   Govender, Patrick ^b   Jagganath, Dinesh ^b  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Luciferase DNA; Polyethylene glycol; Transfection; Transferrin receptor

Indexed keywords

CHLOROQUINE; LUCIFERASE; MACROGOL; MACROGOL DERIVATIVE; POLYLYSINE; RADIOISOTOPE; STREPTAVIDIN; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DRUG COMPLEX; DNA TRANSFECTION; DRUG CONJUGATION; DRUG TARGETING; ENDOCYTOSIS; ENZYME ACTIVITY; GENE TARGETING; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0030958451     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.3109/10717549709051882     Document Type: Article

References (16)

1. Abuchowski, A., Kazo, G. M., Verhoest, C. R., Van Es, T., Kafkewitz, D., Nucci, M. L., Viau, A. T., and Davis, F. F. 1984. Cancer therapy with chemically modified enzymes. 1. Antitumor properties of polyethyleneglycol-asparaginase conjugates. Cancer Biochem. Biophys. 9, 175-186.
2. Cohen, C. M., Kalish, D. I., Jacobson, B. S., and Branton, D. 1977. Membrane isolation on polylysine-coated beads: Plasma membrane from HeLa cells. J. Cell Biol. 75, 119-134.
3. Greber, U. F., and Kasamatsu, H. 1996. Nuclear targeting of SV40 and adenovirus. Trends Cell Biol. 6, 189-195.
4. Katachalsky, A., Danon, D., and Nevo, A. 1959. Interactions of basic polyelectrolytes with the red blood cell. II. Agglutination of red blood cells by polymeric bases. Biochim. Biophys. Acta 33, 120-139.
5. Lee, R. J., and Low, P. S. 1994. Delivery of liposomes into cultured KB cells via folate receptor-mediated encocytosis. J. Biol. Chem. 269, 3198-3204.
6. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
7. Nevo, A., De Vries, A., and Katchalsky, A. 1955. Interaction of polyamino acids with the red blood cell. 1. Combinations of polylysine with single cells. Biochim. Biophys. Acta 17, 536-547.
8. Schoeman, R., Joubert, D., Ariatti, M., and Hawtrey, A. O. 1995. Further studies on targeted DNA transfer to cells using a highly efficient delivery system of biotinylated transfenin and biotinylated polylysine complexed to streptavidin. J. Drug Target. 2, 509-516.
9. Shen, W. C., Yang, D., and Ryser, H. J. P. 1984. Colorimetric determination of microgram quantities of polylysine by trypan blue precipitation. Anal. Biochem. 142, 521-524.
10. Strydom, S., Van Jaarsveld, P., Van Helden, E., Ariatti, M., and Hawtrey, A. O. 1993. Studies on the transfer of DNA into cells through use of avidin-polylysine conjugates complexed to biotinylated transferrin and DNA. J. Drug Target. 1, 165-174.
11. Sweet, D. J., and Gerace, L. 1995. Taking from the cytoplasm and giving to the pore: Soluble transport factors in nuclear protein import. Trends Cell Biol. 5, 444-447.
12. Wagner, E., Cotten, M., Foisner, R., and Birnsteil, M. L. 1991. Transferrin-polycation-DNA complexes. The effect of polycations on the structure of the complex and DNA delivery to cells. Proc. Natl. Acad. Sci. USA 88, 4255-4259.
13. Wagner, E., Plank, C., Zatloukal, K., Cotten, M., and Birnstiel, M. L. 1992b. Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes. Toward a synthetic virus-like gene-transfer vehicle. Proc. Natl. Acad. Sci. USA 89, 7934-7938.
14. Wagner, E., Zatloukal, K., Cotten, M., Kirlappos, H., Mechtler, K., Curiel, D. T., and Birnstiel, M. L. 1992a. Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. Proc. Natl. Acad. Sci. USA 89, 6099-6103.
15. Wagner, E., Zenke, M., Cotten, M., Beug, H., and Bimstiel, M. L. 1990. Transferrin-polycation conjugates as carriers for DNA uptake into cells. Proc. Natl. Acad. Sci. USA 87, 3410-3414.
16. Wang, S., Lee, R. J., Cauchon, G., Gorenstein, D. G., and Low, P. S. 1995. Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol. Proc. Natl. Acad. Sci. USA 92, 3318-3322.