Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death

Synapse

Volumn 26, Issue 2, 1997, Pages 95-103

  Uberti, Daniela ^a   Rizzini, Claudia ^a   Galli, Paola ^a   Pizzi, Marina ^a   Grilli, Mariagrazia ^a   Lesage, Anne ^b   Spano, Pierfranco ^a   Memo, Maurizio ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

cerebellar granule cells; doxorubicin; glutamate; human neuroblastoma SH SY5Y; PCR; Tau proteins

Indexed keywords

DOXORUBICIN; N METHYL DEXTRO ASPARTIC ACID; SABELUZOLE; TAU PROTEIN;

ANIMAL CELL; ARTICLE; CEREBELLUM CORTEX; GRANULE CELL; IMMUNOREACTIVITY; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; RAT;

ANIMALS; CELL DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; HUMANS; NEURONS; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; TAU PROTEINS; THIAZOLES; TIME FACTORS;

EID: 0030958216     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199706)26:2<95::AID-SYN1>3.0.CO;2-8     Document Type: Article

References (28)

1. Argasinski, A., Sternberg, H., Fingado, B., and Huynh, P. (1989) Doxorubicin affects tau protein metabolism in human neuroblastoma cells. Neurochem. Res., 14:927-931.
2. Bergmeyer, H.U. (1974) Biochemical reagents. In: Methods of Enzymatic Analysis, 2nd ed. H.U. Bergmeyer, ed. Academic Press, New York, p. 480.
3. Binder, L.I., Frankfurter, A., and Rubhun, L.I. (1985) The distribution of tau in the mammalian central nervous system. J. Cell Biol., 101:1371-1378.
4. Braak, H., Braak, E., and Grundke-Iqbal, K. (1986) Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments, outside of neurofibrillary tangles and neuritic plaques. Neurosci. Lett., 65:351-355.
5. Caceres, A., and Kosik, K.S. (1990) Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons. Nature, 343:461-464.
6. Chirgwin, J.M., Przybylz, A.E., MacDonald, R.J., and Rutter, W.J. (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry, 18:5294-5299.
7. Chomczynski, P., and Sacchi, N. (1987) Single step method of RNA isolation by acid guanidium thiocyanate-phenol-cloroform extraction. Anal. Biochem., 162:156-159.
8. Clincke, G., and Saghal, A. (1986) R58735, a novel antihypoxic drug improves memory in rats. Drug Dev. Res., 8:381-385.
9. Cole, G.M., Wu, K., and Timiras, P. (1985) A culture model for age-related human neurofibrillary pathology. Int. J. Dev. Neurosci., 3:23-32.
10. Connor, J.A. (1986) Digital imaging of free calcium change and of spatial gradient in growing processes in single, mammalian central nervous system cells. Proc. Natl. Acad. Sci. USA, 83:6179-6183.
11. Dubrin, D.G., and Kirschner, M.W. (1986) Tau protein function in living cells. J. Cell Biol., 103:2739-2746.
12. Dubrin, D.G., Caput, D., and Kirschner, M.W. (1984) Studies of the expression of the microtubule-associated protein, tau, during mouse development, with newly isolated complementary DNA probes. J. Cell Biol., 98:1090-1097.
13. Geerts, H., Nuydenns, R., Nuyens, R., and Cornelissen, F. (1993). Sabeluzole, a prototype drug targeted at the aberrant cytoskeleton. Proceedings of the Fourth International Conference on Alzheimer's Disease, Chicago, Abstract No. 100.
14. Goedert, M. (1993) Tau protein and the neurofibrillary pathology of Alzheimer's disease. TINS, 6:149-154.
15. Goedert, M., Spillantini, M., and Jakes, R. (1991) Localization of the Alz50 epitope in recombinant human microtubule-associated protein tau. Neurosci. Lett., 126:149-154.
16. Jones, K.H., and Senft, J.A. (1985). An improved method to determine cell viability by simultaneous staining with fluorescein diacetate-propidium iodite. J. Histochem. Cytochem., 33:77-84.
17. Kosik, K.S., Orecchio, L.D., Bakalis, S., and Neve, R. (1989) Developmentally regulated expression of specific tau sequences. Neuron, 2:1389-1397.
18. Lang, D.L., Szendrei, G.I., Lee, V.M.Y., and Otuos, L. (1992) Immunological and conformational characterization of a phosphorylated immuno-dominant epitope on the paired helical filament found in Alzheimer's disease. Biochem. Biophys. Res. Commun., 187:783-790.
19. Levi, G., Aloisi, F., Ciotti, M.T., and Gallo, V. (1984) Autoradiographic localization and depolarization-induced release of acidic amino acid in differentiating cerebellar granule cell cultures. Brain Res., 290:77-86.
20. 2+ in monolayers and suspensions of various types of animal cells. J. Cell Biol., 105:2145-2155.
21. 2+ influx in cultured hippocampal neurons. Neuron, 4:105-117.
22. Mize, R.R., Holdefer, R.N., and Nabors, L.B. (1988) Quantitative immunocytochemistry using an image analyzer. I. Hardware evaluation, image processing and data analysis. J. Neurosci. Methods, 26:1-24.
23. 2+-mediated neuronal death in rat brain neuronal cultures by veratridine: Protection by flunarizine. Mol. Pharmacol., 36:525-531.
24. Pauwels, P.J., Leysen, J.E., and Janssen, P.A.J. (1990) Resistance of sabeluzole-treated rat brain neuronal cultures to neuronal damage. Neurosci. Res. Commun., 6:19-25.
25. Pizzi, M., Valerio, A., Arrighi, V., Galli, P., Belloni, M., Ribola, M., Alberici, A., Spano, P.F., and Memo, M. (1995a) Inhibition of glutamate-induced neurotoxicity by a tau antisense oligonucleotide in primary culture of rat cerebellar granule cells. Eur. J. Neurosci., 7:1603-1613.
26. Pizzi, M., Valerio, A., Belloni, M., Arrighi, V., Alberici, A., Liberini, P., Spano, P.F., and Memo, M. (1995b) Differential expression of fetal and mature tau isoforms in primary cultures of rat cerebellar granule cells during differentiation in vitro. Mol. Brain Res., 34:38-44.
27. Tewey, K.M., Chen, G.L., Nelson, E.M., and Liu, L.F. (1994) Interactive anticancer drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J. Biol. Chem., 259:9182-9187.
28. Wauquier, A., Clincke, G., Ashton, D., De Ryck, M., Fransen, J., and Van Clemen, G. (1986) R58735: A new antihypoxic drug with anti-convulsant properties and possible effects on cognitive functions. Drug Dev. Res., 8:373-382.