Antineoplastic agents 370. Isolation and structure of dolastatin 18

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 7, 1997, Pages 827-832

  Pettit, George R ^a   Xu, Jun Ping ^a   Williams, Michael D ^a   Hogan, Fiona ^a   Schmidt, Jean M ^a   Cerny, Ronald L ^b  

^a ARIZONA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DOLASTATIN; DOLASTATIN 10; DOLASTATIN 18; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; CANCER CELL CULTURE; CHIRALITY; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG ISOLATION; HARE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LUNG CANCER; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PAPUA NEW GUINEA;

EID: 0030958211     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00114-5     Document Type: Article

References (17)

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15. (b) Pettit, G. R.; Kamano, Y.; Kizu, H.; Dufresne, C.; Herald, C. L.; Bontems, R. J.; Schmidt, J. M.; Boettner, F. E.; Nieman, R. A. Heterocycles 1989, 28, 553.
16. 3CN (9:1); detection at 230.4 and 550 nm. The retention times (min) of the authentic amino acids were L-Leu (10.39), D-Leu (11.77), L-MePhe (20.16) and D-MePhe (25.68). By comparison with those retention times, the absolute stereochemistry of the two components in the acid hydrolysate of dolastatin 18 (4) were assigned as L-Leu (10.40) and D-MePhe (25.72).
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