Modeling neural mechanisms for genesis of respiratory rhythm and pattern. I. Models of respiratory neurons

Journal of Neurophysiology

Volumn 77, Issue 4, 1997, Pages 1994-2006

  Rybak, Ilya A ^a   Paton, Julian F R ^a   Schwaber, James S ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; POTASSIUM CHANNEL; POTASSIUM ION;

ARTICLE; BRAIN STEM; BREATHING PATTERN; COMPUTER SIMULATION; CONTROLLED STUDY; HODGKIN HUXLEY EQUATION; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE CELL NETWORK; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY NERVE CELL; SYNAPTIC TRANSMISSION;

EID: 0030958168     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1997.77.4.1994     Document Type: Article

References (45)

1. BAUS, U. J., MORRIS, K. F., KOLESKI, J., AND LINDSEY, B. G. Simulations of a ventrolateral medullary neural network for respiratory rhythmogenesis inferred spike train cross-correlation. Biol. Cybern. 70: 311-327, 1994.
2. BOTROS, S. M. AND BRUCE, E. N. Neural network implementation of the three-phase model of respiratory rhythm generation. Biol. Cybern. 63: 143-153, 1990.
3. BRYANT, T. H., YOSHFDA, S., DE CASTRO, D., AND LIPSKI, J. Expiratory neurons of the Bötzinger complex in the rat: a morphological study following intracellular labeling with biocytin. J. Comp. Neurol. 335: 267-282, 1993.
4. CHAMPAGNAT, J., DENAVIT-SAUBIE, M., GRANT, K., AND SHEN, K. F. Organization of synaptic transmission in the mammalian solitary complex, studied in vivo. J. Physiol. Lond. 381: 551-573, 1986a.
5. CHAMPAGNAT, J., JACQUTN. T., AND RICHTER, D. W. Voltage-dependent currents in neurons of the nuclei of the solitary tract of rat brain stem slices. Pfluegers Arch. 406: 372-379, 1986b.
6. CHAMPAGNAT, J. AND RICHTER, D. W. The roles of K conductance in expiratory pattern generation in anaesthetized cats. J. Physiol. Lond. 479: 127-138, 1994.
7. CHAMPAGNAT, J., RICHTER, D. W., JACQUIN, T., AND DENAVIT-SAUBIE, M. Voltage-dependent conductances in neurons of the ventrolateral NTS in rat brain stem slices. In: Neurobiology of the Control of Breathing, edited by C. von Euler and H. Langercrantz. New York: Raven, 1986c, p. 217- 221.
8. CONNOR, J. A. AND STEVENS, C. F. Predictions of repetitive firing behavior from voltage-clamp data on an isolated neurone soma. J. Physiol. Lond. 213: 31-53, 1977.
9. DEKIN, M. S. AND GETTING. P. A. In vitro characterization of neurons in the ventral part of the nucleus tractus solitarius. II. Ionic basis for repetitive firing patterns. J. Neurophysiol. 58: 215-229, 1987.
10. DUFFIN, J. A model of respiratory rhythm generation. Neuroreport 2: 623- 626, 1991.
11. DUFFIN, J. A., EZURE, K., AND LIPSKI, J. Breathing rhythm generation: focus on the rostral ventrolateral medulla. News Physiol. Sci. 10: 133-140, 1995.
12. ECKERT, R. AND CHAD, J. E. Inactivation of Ca channels. Prog. Biophys. Mol. Biol. 44: 215-267, 1984.
13. EZURE, K. Synaptic connections between medullary respiratory neurons and consideration on the genesis of respiratory rhythm. Prog. Neurobiol. 35: 429-450, 1990.
14. FELDMAN, J. L. Neurophysiology of breathing in mammals. In: Handbook of Physiology. The Nervous System. Intrinsic Regulatory Systems of the Brain. Bethesda, MD: Am. Physiol. Soc., 1986, sect. I, vol. IV, p. 463- 524.
15. FELDMAN, J. L. AND CLELAND, C. L. Possible roles of pacemaker neurons in mammalian respiratory rhythmogenesis. In: Cellular Pacemakers, edited by D. O. Carpenter. New York: Wiley, 1982, vol. 2, p. 101-119.
16. FELDMAN, J. L. AND COWAN, J. D. Large scale activity in neural net. II. A model for the brain stem respiratory oscillator. Biol. Cybern. 17: 39-51, 1975.
17. GEMAN, S. AND MILLER, M. Computer simulation of brain stem respiratory activity. J. Appl. Physiol. 41: 931-938, 1976.
18. GOTTSCHALK, A., OGILVIE, M. D., RICHTER, D. W., AND PACK, A. I. Computational aspects of the respiratory pattern generator. Neural Comput. 6: 56-68, 1994.
19. HADDAD, G. G. AND GETTING, P. A. Repetitive firing properties of neurons in the ventral region of nucleus tractus solitarius. In vitro studies in adult and neonatal rat. J. Neurophysiol. 66: 1213-1223, 1989.
20. KILLE, B. Ionic Channels of Excitable Membranes. Sunderland, MA: Sinauer, 1984.
21. HODGKIN, A. L. AND HUXLEY, A. F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. Lond. 117: 500-544, 1952.
22. HUGUENARD, J. R. AND MCCORMICK, D. A. Vclamp and Cclamp. A Computational Simulation of Single Thalamic Relay and Cortical Pyramidal Neurons. Neural Simulation Instruction Manual, Stanford, CA: Stanford Univ., 1991.
23. HUGUENDARD, J. R. AND MCCORMICK, D. A. Simulation of the currents involved in rhythm oscillations in thalamic relay neurons. J. Neurophysiol. 68: 1373-1383, 1992.
24. KLAGES, S., BELLINGHAM, M. C., AND RICHTER. D. W. Late expiratory inhibition of stage 2 expiratory neurons in the cat - a correlate of expiratory termination. J. Physiol. Lond. 70: 1307-1315, 1993.
25. KREUTER, F., RICHTER, D. W., CAMERER, H., AND SENEKOWITSCH, R. Morphological and electrical description of medullary respiratory neurons of the cat. Pfluegers Arch. 372: 7-16, 1977.
26. LUMSDEN, T. Observations on the respiratory centers in the cat. J. Physiol. Lond. 57: 153-160, 1923.
27. MACGREGOR, R. I. Neural and Brain Modeling. New York: Academic, 1987.
28. MCCORMICK, D. A. AND HUGUENARD, J. R. A model of the electrophysiological properties of thalamocortical relay neurons. J. Neurophysiol. 68: 1384-1400, 1992.
29. MIFFLIN, S., BALLANTYNE, D., BACKMAN, S., AND RICHTER, D. W. Evidence for a calcium-activated potassium conductance in medullary respiratory neurons. In: Nerogenesis of Central Respiratory Rhythm, edited by A. M. Bianchi and M. Denvait-Saubie. Lancaster, UK: MTP, 1985, p. 179- 182.
30. OGILVIE, M. D., GOTTSCHALK, A., ANDERS, K., RICHTER, D. W., AND PACK, A. I. A network model of respiratory rhythmogenesis. Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 31): R962-R975, 1992.
31. PATON, J.F.R. The ventral medullary respiratory network of the mature mouse studied in a working heart-brain stem preparation. J. Physiol. Lond. 493: 819-831, 1996.
32. PIERREFICHE, O., CHAMPAGNAT, J., AND RICHTER, D. W. Calcium-dependent conductances control neurones involved in termination of inspiration in cats. Neurosci. Lett. 184: 101-104, 1995.
33. PIERREFICHE, O., FOUTZ, A. S., AND DENAVAIT-SAUBIE, M. Effects of receptor agonists and antagonists on the bulbar respiratory network in cat. Brain Res. 605: 77-84, 1993.
34. RICHTER, D. W. AND BALLANTYNE, D. A three phase theory about the basic respiratory pattern generator. In: Central Neurone Environment, edited by M. Schlafke, H. Koepchen, and W. See. Berlin: Springer, 1983, p. 164-174.
35. RICHTER, D. W., BALLANTYNE, D., AND MIFFLIN, S. Interaction between postsynaptic activities and membrane properties in medullary respiratory neurons. In: Nerogenesis of Central Respiratory Rhythm, edited by A. M. Bianchi and M. Denvait-Saubie. Lancaster, UK: MTP, 1985, p. 172-178.
36. RICHTER, D., BALLANTYNE, D., AND REMMERS, J. E. How is the respiratory rhythm generated? A model. News Physiol. Sci. 1: 109-112, 1986a.
37. RICHTER, D. W., CHAMPAGNAT, J., JACQUIN, T., AND BENACKA, R. Calcium currents and calcium-dependent potassium currents in mammalian medullary respiratory neurons. J. Physiol. Lond. 470: 23-33, 1993.
38. RICHTER, D. W., CHAMPAGNAT, J. S., AND MIFFLIN, S. W. Membrane properties involved in respiratory rhythm generation. In: Neurobiology of the Control of Breathing, edited by C. von Euler and H. Langercrantz. New York: Raven, 1986b, p. 141-147.
39. RICHTER, D. W. Neural regulation of respiration: rhythmogenesis and afferent control. In: Comprehensive Human Physiology, edited by R. Greger and U. Windhorst. Berlin: Springer-Verlag, 1996, vol. II, p. 2079-2095.
40. RUBIO, J. E. A new mathematical model of the respiratory center. Bull. Math. Biophys. 34: 467-481, 1972.
41. SCHWABER, J. S., GRAVES, E. B., AND PATON, J.F.R. Computational modeling of neuronal dynamics for systems analysis: application to cardiovascular NTS neurons in the rat. Brain Res. 604: 126-141, 1993.
42. SCHWARZACHER, S. W., WILHEM, Z., ANDERS, K., AND RICHTER, D. W. The medullary respiratory network in the rat. J. Physiol. Lond. 435: 631- 644, 1991.
43. SMITH, J. C., ELLENBERGER, H., BALLANYI, K., RICHTER, D. W., AND FELDMAN, J. L. Pre-Bötzinger complex: a brain stem region that may generate respiratory rhythm in mammals. Science Wash. DC 254: 726-729, 1991.
44. VON EULER, C. Brain stem mechanism for generation and control of breathing pattern. In: Handbook of Physiology. The Respiratory System. Control of Breathing. Washington, DC: Am. Physiol. Soc., 1986, sect. III, vol. II, p. 1-67.
45. YAMADA, W. M., KOCH, C., AND ADAMS, P. B. Multiple channel and calcium dynamics In: Methods in Neuronal Modeling. Cambridge: MIT, 1989, p. 97-133.