Bulbectomy-induced loss of raphe neurons is counteracted by antidepressant treatment

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 21, Issue 1, 1997, Pages 127-140

  Nesterova, Inna V ^c   Gurevich, Eugenia V ^a,c   Nesterov, Vladimir I ^c   Otmakhova, Nonna A ^b,c   Bobkova, Natalia V ^c  

^a SUN HEALTH RESEARCH INSTITUTE   (United States)

^b BRANDEIS UNIVERSITY   (United States)

^c INSTITUTE OF CELL BIOPHYSICS   (Russian Federation)

Author keywords

antidepressants; bulbectomy; C57Bl 6j mice; locus coeruleus; nucleus raphe dorsalis

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; TRAZODONE;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; INTRAPERITONEAL DRUG ADMINISTRATION; LOCUS CERULEUS; MALE; MOUSE; NERVE CELL; NERVE CELL DEGENERATION; NEUROSURGERY; NONHUMAN; OLFACTORY BULB; RAPHE NUCLEUS;

AMITRIPTYLINE; ANIMALS; ANTIDEPRESSIVE AGENTS; MALE; MICE; MICE, INBRED C57BL; OLFACTORY BULB; RAPHE NUCLEI; TRAZODONE;

EID: 0030958102     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(96)00163-7     Document Type: Article

References (30)

1. ALLEN, L.F., LEFKOWITZ, R.J., CARON, M.G., and COTECCHIA S. (1991) G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the a1B-adrenergic receptor enhances mitogenesis and tumorigenicity. Proc. Natl. Acad. Sci. USA 88: 11354-11358.
2. ANDERSSON, T., MOHAMMED, A.K.H., HENRIKSSON, B.G., WICKMAN, C., NORRBY, E., SCHULTZBERG, M. and KRISTENSSON, K. (1993). Immunochemical and behavior pharmacological analysis of rats inoculated intranasally with vesicular stomatits virus. J. Chem. Neuroanat. 6: 7-18.
3. BOUNA, S., GYSLING, K., CALAS, A., and ARANEDA, S. (1994) Some noradrenergic neurons of locus coeruleus-olfactory pathways contain neuropeptide-Y. Brain Res. Bull. 34: 413-417.
4. BREDESEN, D.E. (1995) Neural apoptosis. Ann. Neurol. 38: 839-851.
5. BROEKKAMP, C.L., GARRIGUO, D. and LLOYD, K.G. (1982). The importance of the amygdala in the effect of antidepressants on olfactory bulbectomized rats. In: Typical and atypical antidepressants: Molecular mechanisms. E. Costa and G. Racagni (Eds.), pp 371-375, Raven Press, New York.
6. BUTLER, J., TANNIAN, M. and LEONARD, B.E. (1988) The chronic effects of desipramine and sertraline on platelet and synaptosomal 5-HT uptake in olfactory bulbectomized rats. Prog Neuropsychopharmacol Biol Psychiatry 12: 585-594.
7. CAIRNCROSS, K.D. (1984) Olfactory bulbectomy as a model of depression. In: Animal models in psychopathology. N.W. Bond (Ed.), pp 99-128, Academic Press, New York.
8. CARLSEN, J., DE OLMOS, J. and HEIMER, L. (1982) Tracing of the two-neuron pathways in the olfactory system by the aid of transneuronal degeneration: Projections to the amygdaloid body and hippocampal formation. J. Comp. Neurol. 208: 196-208.
9. CHARRIAUT-MARLANGUE, C., AGGOUN-ZOUAOUI, D., REPRESA, A., and BEN-ARI, Y. (1996) Apoptotic features of selective neuronal death in ischemia, epilepsy and gp120 toxicity. Trends in Neurosci. 19:109-116.
10. DREYER, D.A., LAGARNGE, A., GROTHR, C., and UNICKER, K. (1989). Basic fibroblast growth factor prevents ontogenetic neuron death in vitro. Neurosci. Lett. 99: 35-38.
11. FUKUDA, H., NISHIDA, A., SAITO, H., SHIMAZU, M and YAMAWAKI, S. (1994) Imipramine stimulates phospholipase C activity in rat brain. Neurochem Int 25: 567-571
12. 1A receptors in mice. Pharmacol. Biochem. Behav. 45: 67-70.
13. GUTKIND, J.S., NOVOTNY, E.A., BRANN, M.R., and ROBBINS, K.C. (1991) Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. Proc. Natl. Acad. Sci. USA 88: 4703-4707.
14. HEIMER, L. and KALIL, R. (1978) Rapid transneuronal degeneration and death of cortical neurons following removal of the olfactory bulbs in adult rats. J. Comp. Neuro. 178: 559-610.
15. HOCKENBERY, D.M., ZUTTER, M., HICKEY, W., NAHM, M., and KORSMEYRR, S.J. (1991) Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Nat. Acad. Sci. U.S.A. 88: 6961-6965
16. HUNEYCUTT, B.S., PLAKHOV, I.V., SHUSTERMAN, Z., BARTIDO, S.M., HUANG, A., REISS, C.S. and AOKI, C. (1994) Distribution of vesicular stomatitis virus proteins in the brain of BALB/c mice following intranasal inoculation: An immunohistochemical analysis. Brain Res. 635: 81-95.
17. JESBERGER, J.A. and RICHARDSON, J.S. (1988) Brain output disregulation induced by olfactory bulbectomy: An approximation in the rat of major depressive disorder in humans? Int. J. Neurosci. 38: 241-265.
18. JULIUS, D., LIVELLI, T.J., JESSELL, T.M., and AXEL, R. (1989) Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation. Science 244: 1057-1062.
19. LILLIE, R.D. (1965) Histopathological technique and practical histochemistry. MacGraw-Hiel Book Co., New York
20. LUMIA, A.R., TEICHER, M.H., SALCHLI, F., AYERS, E. and POSSIDENTE, B. (1992) Olfactory bulbectomy as a model for agitated hyposerotonergic depression. Brain Res. 587: 181-185.
21. MCLEAN, J.H. and SHIPLEY, M.T. (1987) Serotonergic afferents to the rat olfactory bulb: I. Origins and laminar specificity of serotonergic inputs in the adult rat. J. Neurosci. 7: 3016-3028.
22. MCLEAN, J.H., SHIPLEY, M.T., NICKELL, W.T., ASTON-JONES, G. and REYHER, K.K.H. (1989) Chemoanatomical organization of the noradrenergic input from locus coeruleus to the olfactory bulb of the adult rat. J. Comp. Neurol. 285: 339-349.
23. MCLEAN, J.H., SHIPLEY, M.T., BERNSTAIN, D.I. and CORBETT, D. (1993) Selective lesion of neural pathways following viral inoculation of the olfactory bulb. Exp. Neurol. 122: 209-222.
24. MICHEL, D., MOYSE, E., BRUN, G., and JOURDAN, F. (1994) Induction of apoptosis in rat olfactory neuroepithelium by synaptic target ablation. Neuroreport 5: 1329-1332.
25. OTMAKHOVA, N.A., GUREVICH, E.V., KATKOV, Yu.A., NESTEROVA, I.V. and BOBKOVA, N.V. (1992) Dissociation of multiple behavior effects between olfactory bulbectomized C57B1/6j and DBA/2j mice. Physiol. Behav. 52: 441-448
26. SHIMIZU, M., NISHIDA, A. and YAMAWAKI, S. (1993a). Forskolin and phorbol myristate acetate inhibit intracellular Ca2+ mobilization induced by amitriptyline and bradikinin in rat frontocortical neurons. J. Neurochem. 61: 1748-1754
27. SHIMIZU, M., NISHIDA, A., HAYAKAWA, H. and YMAWAKI, S. (1993b) Ca2+ release from inositol 1,4,5-triphosphate-sensitive Ca2+ store by antidepressant drugs in cultured neurons of rat frontal cortex. J. Neurochem. 60: 595-601
28. SWITZER, R.C., DE OLMOS, J. and HEIMER, L. (1985) Olfactory system. In: The rat nervous system. Paxinos G. (Ed.), pp 1-36, Academic Press, Sydney.
29. VAN RIESEN, H. and LEONARD, B.E. (1991) Effects of psychotropic drugs on the behavior and neurochemistry of olfactory bulbectomized rats. In: Psychopharmacology of anxiolytics and antidepressants. File S.E. (Ed.), pp 231-250, Pergamon Press, New York.
30. WILLNER P. (1990) Animal models of depression: An overview. Pharmacol. Therapy 45:425-454.