Time-dependent inhibition of neuronal nitric oxide synthase by N-propargylguanidine

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 11, 1997, Pages 1449-1454

  Fast, Walter ^a   Huff, Mary Elizabeth ^a   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL TISSUE; ARTICLE; BRAIN; CATTLE; DOSE TIME EFFECT RELATION; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN;

EID: 0030958016     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00241-2     Document Type: Article

References (18)

1. Kerwin, J. F.; Heller, M. Med. Res. Rev. 1994, 14, 23.
2. Kerwin, J. F.; Lancaster, J. R., Jr.; Feldman, P. L. J. Med. Chem. 1995, 38, 4343.
3. Marietta, M. A. J. Med. Chem. 1994, 37, 1899.
4. (a) Silverman, R. B. Mechanism-Based Enzyme Inactivation: Chemistry and Enzymology; CRC: Boca Raton 1988, Vol. I and II.
5. (b) Silverman, R. B. Methods Enzymol. 1995, 249, 240.
6. Olken, N. M.; Marletta, M. A. J. Med. Chem. 1992, 35, 1137.
7. Zhang, H. Q.; Dixon, R. P.; Marletta, M. A.; Silverman, R. B., manuscript submitted.
8. Fast, W.; Levsky, M. E.; Marletta, M. A.; Silverman, R. B., Bioorg. Med. Chem. 1997, in press.
9. (a) Ortiz de Montellano, P. R.; Kunze, K. L. J. Biol. Chem. 1980, 255, 5578.
10. (b) Ortiz de Montellano, P. R.; Komives, E. A. J. Biol. Chem. 1985, 260, 3330.
11. (a) Maycock, A. L.; Abeles, R. H.; Salach, J. L; Singer, T. P. Biochemsitry 1976, 15, 114.
12. (b) Kalgutkar, A. S.; Castagnoli, Jr., N.; Testa, B. Med. Res. Rev. 1995, 15, 325.
13. 3Cl: C, 35.97; H, 6.04; N, 31.46. Found: C, 35.89; H, 5.86; N, 31.26.
14. Bernatowicz, M. S.; Wu, Y.; Matsueda, G. R. J. Org. Chem. 1992, 57, 2497.
15. Furfine, E. S.; Harmon, M. F.; Paith, J. E.; Garvey, E. P. Biochemistry 1993, 32, 8512.
16. The procedure is the same as reported in references 6 and 7.
17. Kitz, R.; Wilson, I. B. J. Biol. Chem. 1962, 237, 3245.
18. Wolff, D. J.; Lubeskie, A. Arch. Biochem. Biophys. 1996, 325, 227.