Steady-state pharmacokinetics of oral sustained-release morphine sulphate in dogs

Journal of Veterinary Pharmacology and Therapeutics

Volumn 20, Issue 2, 1997, Pages 129-133

  Dohoo, S ^a  

^a UNIVERSITY OF PRINCE EDWARD ISLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE SULFATE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; DOG; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; FEMALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RADIOIMMUNOASSAY; STEADY STATE; SUSTAINED RELEASE PREPARATION;

ANIMALIA; CANIS FAMILIARIS;

EID: 0030957427     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2885.1997.00816.x     Document Type: Article

References (11)

1. Dohoo, S.E., Tasker, R.A.R. & Donald, A. (1994) Pharmacokinetics of parenteral and oral sustained-release morphine sulfate in dogs. Journal of Veterinary Pharmacology and Therapeutics, 17, 426-433.
2. Flecknell, P.A. (1984) The relief of pain in laboratory animals. Laboratory Animals, 18, 147-160.
3. Gibaldi, M. & Perrier, D. (1982) Multiple dosing. In Pharmacokinetics, 2nd edn. p. 143. Marcel Dekker Inc., New York.
4. Gong, Q-L., Hedner, J., Bjorkman, R. & Hedner, T. (1992) Morphine-3-glucuronide may functionally antagonize morphine-6-glucuronide induced antinociception and ventilatory depression in the rat. Pain, 48, 249-255.
5. Gourlay, G.K., Plummer, J.L. & Cherry, D.A. (1995) Chronopharmacokinetic variability in plasma morphine concentrations following oral doses of morphine solution. Pain, 61, 375-381.
6. Hansen, B. (1994) Cancer pain. Proceedings of the 12th Annual Veterinary Medical Forum, American College of Veterinary Internal Medicine, San Francisco, CA. pp. 849-853.
7. Hollander, M. & Wolfe, D.A. (1973) The two-way layout. In Nonparametric Statistical Methods, pp. 139-146. John Wiley and Sons, New York.
8. Jaffe, J.H. & Martin, W.R. (1990) Opioid analgesics and antagonists. In The Pharmacological Basis of Therapeutics, 8th edn. Eds Goodman, L.S., Gilman, A., Rall, W.R., Nies, A.S. & Taylor, P., pp. 485-521. Pergamon Press.
9. Kyles, E.K. (1995) Clinical pain management. Perspectives. March/April, 6-12.
10. Osborne, R., Joel, S., Trew, U. & Slevin, M. (1990) Morphine and metabolite behaviour after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide. Clinical Pharmacology and Therapeutics, 47, 12-19.
11. Shimomura, K., Kamata, O., Ueki, S., Ida, S., Oguri, K., Yoshimura, H. & Tsukamoto, H. (1971) Analgesic effects of morphine glucuronides, Tohoku Journal of Experimental Medicine, 105, 45-52.