Epitope-defined monoclonal antibodies against type-IV collagen for diagnosis of Alport's syndrome

Nephrology Dialysis Transplantation

Volumn 12, Issue 6, 1997, Pages 1238-1241

  Kagawa, M ^b   Kishiro, Y ^b   Naito, I ^b   Nemoto, T ^b   Nakanishi, H ^b   Ninomiya, Y ^b   Sado, Y ^a  

^a Shigei Medical Research Institute   (Japan)

^b NONE

Author keywords

Alport's syndrome; Diagnosis; Kidney biopsy; Monoclonal antibodies; Skin biopsy; Type IV collagen

Indexed keywords

COLLAGEN TYPE 4; EPITOPE; MONOCLONAL ANTIBODY;

ALPORT SYNDROME; ARTICLE; HUMAN; HUMAN TISSUE; KIDNEY BIOPSY; PRIORITY JOURNAL; SKIN BIOPSY;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; COLLAGEN; EPITOPES; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; HUMANS; KIDNEY; MOLECULAR SEQUENCE DATA; NEPHRITIS, HEREDITARY; SKIN;

EID: 0030957210     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/12.6.1238     Document Type: Article

References (19)

1. Barker DF, Hostikka SL, Zhou J et al. Identification of mutations in the COL4A5 collagen gene in Alport syndrome. Science 1990; 248: 1224-1226
2. Hostikka SL, Eddy RL, Byers MG, Höyhtya M, Shows TB, Tryggvason K. Identification of a distinct type IV collagen α chain with restricted kidney distribution and assignment of its gene to the locus of X chromosome-linked Alport syndrome. Proc Natl Acad Sci USA 1990; 87: 1606-1610
3. Mochizuki T, Lemmink HH, Mariyama M et al. Identification of mutations in the α3(IV) and α4(IV) collagen genes in autosomal recessive Alport syndrome. Nature Genet 1994; 8: 77-82
4. Mariyama M, Zheng KG, Yangfeng TL, Reeders ST. Colocalization of the genes for the α3(IV) and α4(IV) chains of type-IV collagen to chromosome-2 bands-q35-q37. Genomics 1992; 13: 809-813
5. Yoshioka K, Hino S, Takemura T et al. Type IV collagen α5 chain: Normal distribution and abnormalities in X-linked Alport syndrome revealed by monoclonal antibody. Am J Pathol 1994; 144: 986-996
6. Nakanishi K, Yoshikawa N, Iijima K et al. Immunohistochemical study of α1-5 chains of type IV collagen in hereditary nephritis. Kidney Int 1994; 46: 1413-1421
7. Tryggvason K, Zhou J, Hostikka SL, Shows TB. Molecular genetics of Alport syndrome. Kidney Int 1993; 43: 38-44
8. Gubler M-C, Knebelmann B, Beziau A et al. Autosomal recessive Alport syndrome: Immunohistochemical study of type IV collagen chain distribution. Kidney Int 1995; 47: 1142 1147
9. Ninomiya Y, Kagawa M, Iyama K et al. Differential expression of two basement membrane collagen genes, COL4A6 and COL4A5, demonstrated by immunofluorescence staining using peptide-specific monoclonal antibodies. J Cell Biol 1995; 130: 1219-1229
10. Sado Y, Kagawa M, Kishiro Y et al. Establishment by the rat lymph node method of epitope-defined monoclonal antibodies recognizing the six different α chains of human type IV collagen. Histochem Cell Biol 1995; 104: 267-275
11. Kishiro Y, Kagawa M, Naito I, Sado Y. A novel method of preparing rat-monoclonal antibody-producing hybridomas by using rat medial iliac lymph node cells. Cell Struct Funct 1995; 20: 151-156
12. Brazel D, Pollner R, Oberbaumer I, Kuhn K. Human basement membrane collagen (type IV). The amino acid sequence of the α2(IV) chain and its comparison with the α1(IV) chain reveals deletions in the α1(IV) chain. Eur J Biochem 1988; 172: 35-42
13. Hostikka SL, Tryggvason K. The complete primary structure of the α2 chain of human type IV collagen and comparison with the α1(IV) chain. J Biol Chem 1988; 263: 19488-19493
14. Zhou J, Hertz JM, Leinonen A, Tryggvason K. Complete amino acid sequence of the human α5(IV) collagen chain and identification of a single-base mutation in exon 23 converting glycine 521 in the collagenous domain to cysteine in an Alport syndrome patient. J Biol Chem 1992; 267: 12475-12481
15. Maloy WL, Coligan JE, Paterson Y. Production of antipeptide antisera. In: Coligan JE, Kruisbeek AM, Margulies DH, Shevach, Strober W, (ed.) Current Protocols in Immunology, John Wiley, New York, 1991; ch 9.4.1
16. Sugihara K, Sado Y, Ninomiya Y, Wada H. Experimental anti-GBM glomerulonephritis induced in rats by immunization with synthetic peptides based on six a chains of human type IV collagen. J Pathol 1996; 178: 352-358
17. Kevin H, Foulkes BJ. Preparation of cells and reagents for flow cytochemistry. In: Coligan JE, Kruisbeek AM, Margulies DH, Shevach, Strober W, (ed.) Current Protocols in Immunology, John Wiley, New York, 1991; ch 5.3.1
18. Geysen HM, Rodda SJ, Mason TJ, Tribbick G, Schoofs PG. Strategies for epitope analysis using peptide synthesis. J Immunol Methods 1987; 102: 259-274
19. Kawai S, Nomura S, Harano T, Harano K, Fukushima T, Osawa G, Japanese Alport Network. The COL4A5 gene in Japanese Alport syndrome patients. Spectrum of mutations of all exons. Kidney Int 1996; 49: 814-822