Synthesis and inhibitory effect of a trisubstrate transition state analogue for UDP glucuronosyltransferases

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 12, 1997, Pages 1501-1506

  Timmers, C M ^a   Dekker, M ^a   Buijsman, R C ^a   Van Der Marel, G A ^a   Ethell, B ^b   Anderson, G ^b   Burchell, B ^b   Mulder, G J ^c   Van Boom, J H ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1 NAPHTHOL; 8 QUINOLINOL; ANDROSTANE DERIVATIVE; ENZYME INHIBITOR; ETHINYLESTRADIOL; GLUCURONOSYLTRANSFERASE; ISOENZYME; PROPOFOL; TRANSFERASE INHIBITOR; URIDINE DERIVATIVE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOCHEMISTRY;

EID: 0030957158     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00251-5     Document Type: Article

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19. -.
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22. 14C]-Labelled UDP-GlcA and glucuronide detection was executed by a heterogeneous radiochemical method using a 500 μL flow cell packed with silanized cerium-activated glass as scintillant. Two independent experiments were carried out in each assay.