Steric and electronic control in the addition of hydrazine and phenylhydrazine to α-[(dimethylamino)methylene]-β-oxoarylpropanenitriles

Synthesis

Volumn , Issue 3, 1997, Pages 337-341

  Tupper, David E ^a   Bray, Mark R ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PYRAZOLE DERIVATIVE;

ARTICLE; CHIRALITY; DRUG SYNTHESIS; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030956935     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1997-1186     Document Type: Article

References (13)

1. Field, G. F.; Schneider, J. U. Ger. Offen. DE2330913, 1974; Chem. Abstr. 1974, 80, 95566.
2. Gilkerson, T.; Shaw, R. W. European Patent 0348002, 1989; Chem. Abstr. 1990, 113, 5962.
3. Foster, J. F.; Gilkerson, T.; Stooker, R. U. K. Patent 2238789, 1991; Chem. Abstr. 1991, 115, 279611.
4. Dusza, J. P.; Church, R. F. U. S. Patent 5059709, 1991; Chem. Abstr. 1992, 116, 83392.
5. Morimura, S. Heterocycles 1980, 14, 1449.
6. Tomcufcik, A. S.; Dusza, J. P. Ger. Offen. DE3422876, 1984; Chem. Abstr. 1985, 102, 185077.
7. Grothaus, C. E.; Dains, F. B. J. Am. Chem. Soc. 1936, 58, 1334.
8. Nishiwaki, T.; Fujiyama, F.; Minamisono; E. J. Chem. Soc., Perkin Trans 1 1974, 1871.
9. Eby, C. J.; Hauser, C. R. J. Am. Chem. Soc. 1957, 79, 723.
10. Drauz, K.; Kleeman, A.; Wolfheuss, E. Ger. Offen. DE3209472, 1983, Chem. Abstr. 1984, 100, 51289.
11. Krauss, J. C.; Cupps, T. L.; Wise, D. S.; Townsend, L. B. Synthesis 1983, 308.
12. Shioiri, T.; Hamada, Y. J. Org. Chem. 1978, 43, 3631.
13. Wemple, J.N.; Zeller, J.R.; Domagala, J. M. JP 62167769, 1987, Chem. Abstr. 1988, 108, 167325.