Efficacy of trimethoprim in murine experimental infection with a thymidine kinase-deficient mutant of Escherichia coli

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 5, 1997, Pages 1042-1045

  Tokunaga, Tetsuhiro ^a,b   Oka, Kaori ^a   Takemoto, Akiko ^a   Ohtsubo, Yoshikazu ^a,b   Gotoh, Naomasa ^a   Nishino, Takeshi ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b SAWAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CEFDINIR; OFLOXACIN; SULFAMETHOXAZOLE; THYMIDINE; THYMIDINE KINASE; TRIMETHOPRIM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERICIDAL ACTIVITY; DRUG EFFICACY; ENTEROBACTER INFECTION; ENZYME ACTIVITY; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030956598     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.5.1042     Document Type: Article

References (24)

1. Bliss, C. I. 1981. The method of probit. Science 79:76-79.
2. Boyce, R. P., and R. B. Setlow. 1962. A simple method of increasing the incorporation of thymidine into the deoxyribonucleic acid of Escherichia coli. Biochim. Biophys. Acta 61:618-620.
3. Burchall, J. J., and G. H. Hitchings. 1965. Inhibitor binding analysis of dihydrofolate reductases from various species. Mol. Pharmacol. 1:126-136.
4. Fujii, Y. 1973. Methods of sensitivity testing for sulfamethoxazole-trimethoprim combination product. Ad hoc committee of the Japan Society of Chemotherapy for the evaluation of sensitivity testing methods for sulfamethoxazole and trimethoprim. Chemotherapy 21:67-76.
5. 3H-labeled nucleotides. Anal. Biochem. 5:512-522.
6. Grunberg, E., W. F. Delorenzo, and E. Titsworth. 1970. Demonstration of the therapeutic effectiveness of sulfamethoxazole in experimental infections of mice. Chemotherapy 15:99-104.
7. Hamilton-Miller, J. M. T. 1988. Reversal of activity of trimethoprim against Gram-positive cocci by thymidine, thymine and 'folates.' J. Antimicrob. Chemother. 22:35-39.
8. Hiraga, S., K. Igarashi, and T. Yura. 1967. A deoxythymidine kinase-deficient mutant of Escherichia coli. Biochim. Biophys. Acta 145:41-51.
9. Hitchings, G. H. 1969. Species differences among dihydrofolate reductases as a basis for chemotherapy. Postgrad. Med. J. 45(Suppl.):7-10.
10. Hitchings, G. H., and J. J. Burchall. 1965. Inhibition of folate biosynthesis and function as a basis for chemotherapy. Adv. Enzymol. 27:417-468.
11. Kammen, H. O. 1967. Thymine metabolism in Escherichia coli. I. Factors involved in utilization of exogenous thymine. Biochim. Biophys. Acta 134: 301-311.
12. Koch, A. E., and J. J. Burchall. 1971. Reversal of the antimicrobial activity of trimethoprim by thymidine in commercially prepared media. Appl. Microbiol. 22:812-817.
13. Krenitsky, T. A., M. Barclay, and J. A. Jacquez. 1964. Specificity of mouse uridine phosphorylase. J. Biol. Chem. 239:805-812.
14. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
15. Meshi, T., and Y. Sato. 1972. Studies on sulfamethoxazole/trimethoprim. Absorption, distribution, excretion and metabolism of trimethoprim in rat. Chem. Pharm. Bull. 20:2079-2090.
16. Nottebrock, H., and R. Then. 1977. Thymidine concentrations in serum and urine of different animal species and man. Biochem. Pharmacol. 26:2175-2179.
17. Schwartz, D. E., and J. Rieder. 1970. Pharmacokinetics of sulfamethoxazole + trimethoprim in man and their distribution in rat. Chemotherapy 15:337-355.
18. Schwartz, D. E., W. Vetter, and G. Englert. 1970. Trimethoprim metabolites in rat, dog and man: qualitative and quantitative studies. ArzneimiForsch. 12:1867-1871.
19. Stokes, A., and R. W. Lacey. 1978. Effect of thymidine on activity of trimethoprim and sulfamethoxazole. J. Clin. Pathol. 31:165-171.
20. Sugino, A. 1977. Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene products and its relationship to DNA gyrase and a novel nicking-closing enzyme. Proc. Natl. Acad. Sci. USA 74:4767-4771.
21. Then, R. 1993. Discussion: microbiology. J. Chemother. 5:444-446.
22. Then, R., and P. Angehrn. 1974. The biochemical basis of the antimicrobial action of sulfonamide and trimethoprim in vivo. Biochem. Pharmacol. 23: 2977-2982.
23. Tomasz, A. 1979. The mechanism of irreversible antimicrobial effects of penicillins: how the beta-lactam antibiotics kill and lyse bacteria? Annu. Rev. Microbiol. 33:133-137.
24. Wachsman, J. T., S. Kemp, and L. Hogg. 1964. Comparative effects of 5-fluorouracil on strains of Bacillus megaterium. J. Bacteriol. 87:1011-1018.