-
1
-
-
0028221989
-
Topiramate: Preclinical evaluation of a structurally novel anticonvulsant
-
Shank RP, Gardocki JF, Vaught JL, el al. Topiramate: preclinical evaluation of a structurally novel anticonvulsant. Epilepsia 1994;35:450-60.
-
(1994)
Epilepsia
, vol.35
, pp. 450-460
-
-
Shank, R.P.1
Gardocki, J.F.2
Vaught, J.L.3
-
2
-
-
0027736513
-
Antiepileptic drugs in clinical development
-
Ramsay RE, Slater JD. Antiepileptic drugs in clinical development. Epilepsy Res 1993;10(suppl):45-67.
-
(1993)
Epilepsy Res
, vol.10
, Issue.SUPPL.
, pp. 45-67
-
-
Ramsay, R.E.1
Slater, J.D.2
-
3
-
-
0000892632
-
Estimation of the absolute bioavailability of topiramate in humans without intravenous data
-
Nayak RK, Gisclon LG, Curtin CA, Benet LZ. Estimation of the absolute bioavailability of topiramate in humans without intravenous data [Abstract]. J Clin Pharmacol 1994;34:1029.
-
(1994)
J Clin Pharmacol
, vol.34
, pp. 1029
-
-
Nayak, R.K.1
Gisclon, L.G.2
Curtin, C.A.3
Benet, L.Z.4
-
4
-
-
1842305299
-
The pre-clinical profile of topiramate: A structurally novel anticonvulsant drug
-
Oslo, Norway, July
-
Kramer LD. The pre-clinical profile of topiramate: a structurally novel anticonvulsant drug [Abstract]. The 20th International Epilepsy Congress, Oslo, Norway, July 1993.
-
(1993)
The 20th International Epilepsy Congress
-
-
Kramer, L.D.1
-
5
-
-
0001558271
-
Evaluation of the absorption, excretion, pharmacokinetics and metabolism of the anticonvulsant, topiramate in healthy men
-
Wu WN, Heebner JB, Streeter AJ, et al. Evaluation of the absorption, excretion, pharmacokinetics and metabolism of the anticonvulsant, topiramate in healthy men [Abstract]. Pharm Res 1994;11(suppl):S-336.
-
(1994)
Pharm Res
, vol.11
, Issue.SUPPL.
-
-
Wu, W.N.1
Heebner, J.B.2
Streeter, A.J.3
-
6
-
-
0001052465
-
Plasma pharmacokinetics of topiramate, a new anticonvulsant in humans
-
Easterling DE, Zakszewski T, Moyer MD, Margul BL, Marriott TB, Nayak RK. Plasma pharmacokinetics of topiramate, a new anticonvulsant in humans [Abstract]. Epilepsia 1988;29:662.
-
(1988)
Epilepsia
, vol.29
, pp. 662
-
-
Easterling, D.E.1
Zakszewski, T.2
Moyer, M.D.3
Margul, B.L.4
Marriott, T.B.5
Nayak, R.K.6
-
7
-
-
0002275260
-
The steady-state (SS) pharmacokinetics of phenytoin (Dilantin) and of topiramate (Topamax) in epileptic patients on monotherapy and during combination therapy
-
Gisclon LG, Curtin CR, Krarner LD, Sachdeo RC, Levy RH. The steady-state (SS) pharmacokinetics of phenytoin (Dilantin) and of topiramate (Topamax) in epileptic patients on monotherapy and during combination therapy [Abstract]. Epilepsia 1994;35(suppl 8):54.
-
(1994)
Epilepsia
, vol.35
, Issue.SUPPL. 8
, pp. 54
-
-
Gisclon, L.G.1
Curtin, C.R.2
Krarner, L.D.3
Sachdeo, R.C.4
Levy, R.H.5
-
8
-
-
0029845689
-
Steady-state pharmacokinetics of topiramate and carbamazepinc in patients with epilepsy during monotherapy and concomitant therapy
-
Sachdeo RC, Sachdeo SK. Walker SA, Kramer LD, Nayak RK, Doose DR. Steady-state pharmacokinetics of topiramate and carbamazepinc in patients with epilepsy during monotherapy and concomitant therapy. Epilepsia 1996;37:774-80.
-
(1996)
Epilepsia
, vol.37
, pp. 774-780
-
-
Sachdeo, R.C.1
Sachdeo, S.K.2
Walker, S.A.3
Kramer, L.D.4
Nayak, R.K.5
Doose, D.R.6
-
9
-
-
0003059953
-
Explanation and prediction of drug interactions with topiramate using CYP450 inhibition spectrum
-
Levy RH, Bishop F, Streeter AJ, et al. Explanation and prediction of drug interactions with topiramate using CYP450 inhibition spectrum [Abstract]. Epilepsia 1995;36(suppl 4):47.
-
(1995)
Epilepsia
, vol.36
, Issue.SUPPL. 4
, pp. 47
-
-
Levy, R.H.1
Bishop, F.2
Streeter, A.J.3
-
10
-
-
1842263787
-
Evaluation of the potential pharmacokinetic interaction between topiramate and the oral contraceptive combination, norethindrone/ ethinyl estradiol
-
Doose DR. Rosenfeld WE, Schaefer P, Walker SA, Nayak RK. Evaluation of the potential pharmacokinetic interaction between topiramate and the oral contraceptive combination, norethindrone/ ethinyl estradiol [Abstract]. J Clin Pharmacol 1994;34;1031.
-
(1994)
J Clin Pharmacol
, vol.34
, pp. 1031
-
-
Doose, D.R.1
Rosenfeld, W.E.2
Schaefer, P.3
Walker, S.A.4
Nayak, R.K.5
-
11
-
-
0028045747
-
Valproic acid: A reappraisal of its pharmacokinetic properties and clinical efficacy in epilepsy
-
Davis R, Peters DH, McTavish D. Valproic acid: a reappraisal of its pharmacokinetic properties and clinical efficacy in epilepsy. Drugs 1994;47:332-72.
-
(1994)
Drugs
, vol.47
, pp. 332-372
-
-
Davis, R.1
Peters, D.H.2
McTavish, D.3
-
12
-
-
0023135810
-
Valproic acid hepatic fatalities: A retrospective review
-
Dreifuss FE, Saniilli N, Langer DH, Sweeney KP, Moline KA, Menander KB. Valproic acid hepatic fatalities: a retrospective review. Neurology 1987;37:379-85.
-
(1987)
Neurology
, vol.37
, pp. 379-385
-
-
Dreifuss, F.E.1
Saniilli, N.2
Langer, D.H.3
Sweeney, K.P.4
Moline, K.A.5
Menander, K.B.6
-
13
-
-
0021646542
-
The hepatotoxicity of valproic acid and its metabolites in rats. I. Toxicologic, biochemical and histopalhologic studies
-
Kesterson JW, Granneman GR, Machinist JM. The hepatotoxicity of valproic acid and its metabolites in rats. I. Toxicologic, biochemical and histopalhologic studies. Hepatology 1984;4:1143-52.
-
(1984)
Hepatology
, vol.4
, pp. 1143-1152
-
-
Kesterson, J.W.1
Granneman, G.R.2
Machinist, J.M.3
-
14
-
-
0020622593
-
The toxicity of the metabolites of sodium valproate in cultured hepalocytes
-
Kingsley E, Gray P, Tolman KG, Tweedale R. The toxicity of the metabolites of sodium valproate in cultured hepalocytes. J Clin Pharmacol 1983;23:178-85.
-
(1983)
J Clin Pharmacol
, vol.23
, pp. 178-185
-
-
Kingsley, E.1
Gray, P.2
Tolman, K.G.3
Tweedale, R.4
-
15
-
-
0025992079
-
Clinical trials of investigational antiepileptic drugs: Monotherapy designs
-
Pledger GW, Kramer LD. Clinical trials of investigational antiepileptic drugs: monotherapy designs. Epilepsia 1991;32:716-21.
-
(1991)
Epilepsia
, vol.32
, pp. 716-721
-
-
Pledger, G.W.1
Kramer, L.D.2
-
16
-
-
0005666183
-
A capillary GC assay with NPD detection for the quantification of topiramate in human plasma
-
Cooper JM, Stubbs RJ, Palmer ME. A capillary GC assay with NPD detection for the quantification of topiramate in human plasma [Abstract]. Pharm Res 1991;10(suppl 8):19.
-
(1991)
Pharm Res
, vol.10
, Issue.SUPPL. 8
, pp. 19
-
-
Cooper, J.M.1
Stubbs, R.J.2
Palmer, M.E.3
-
17
-
-
0024549456
-
Quantitative metabolic profiling of valproic acid in humans using automated gas Chromatographic/mass spectrometric techniques
-
Rettenmeier AW, Howard WN, Levy RH, et al. Quantitative metabolic profiling of valproic acid in humans using automated gas Chromatographic/mass spectrometric techniques. Biomed Environ Mass Spectrom 1989;18:192-9.
-
(1989)
Biomed Environ Mass Spectrom
, vol.18
, pp. 192-199
-
-
Rettenmeier, A.W.1
Howard, W.N.2
Levy, R.H.3
-
18
-
-
0025007782
-
Effects of polytherapy with phenytoin, carbamazepine, and stiripentol on formation of 4-ene-valproate, a hepatotoxic metabolite of valproic acid
-
Levy RH, Rettenmeier AW, Anderson GD, et al. Effects of polytherapy with phenytoin, carbamazepine, and stiripentol on formation of 4-ene-valproate, a hepatotoxic metabolite of valproic acid. Clin Pharmacol Ther 1990;48:225-35.
-
(1990)
Clin Pharmacol Ther
, vol.48
, pp. 225-235
-
-
Levy, R.H.1
Rettenmeier, A.W.2
Anderson, G.D.3
-
19
-
-
0003419256
-
-
Cary, NC: SAS Institute
-
SAS (Statistical Analysis System). User's Guide: Statistics. Cary, NC: SAS Institute, 1982.
-
(1982)
User's Guide: Statistics
-
-
-
22
-
-
0020468065
-
Drug interactions with valproic acid
-
Levy RH, Koch KM. Drug interactions with valproic acid. Drugs 1982;24:543-56.
-
(1982)
Drugs
, vol.24
, pp. 543-556
-
-
Levy, R.H.1
Koch, K.M.2
-
23
-
-
0019195809
-
Interactions of valproic acid with phenytoin
-
Bruni J, Gallo JM, Lee CS, Perchalski RJ, Wilder BJ. Interactions of valproic acid with phenytoin. Neurology 1980;30:1233-6.
-
(1980)
Neurology
, vol.30
, pp. 1233-1236
-
-
Bruni, J.1
Gallo, J.M.2
Lee, C.S.3
Perchalski, R.J.4
Wilder, B.J.5
-
25
-
-
0025319879
-
Carbamazepine metabolism in humans: Effect of concurrent anliconvulsant therapy
-
Ramsay RE, McManus DQ, Guterman A, et al. Carbamazepine metabolism in humans: effect of concurrent anliconvulsant therapy. Ther Drug Monit 1990;12:235-41.
-
(1990)
Ther Drug Monit
, vol.12
, pp. 235-241
-
-
Ramsay, R.E.1
McManus, D.Q.2
Guterman, A.3
-
26
-
-
0026578315
-
Variability and clinical relevance of the interaction between sodium valproate and carbamazepine in epileptic patients
-
McKee PJW, Blacklaw J, Butler E, Gillnam RA, Brodie MJ. Variability and clinical relevance of the interaction between sodium valproate and carbamazepine in epileptic patients. Epilepsy Res 1992;11:193-8.
-
(1992)
Epilepsy Res
, vol.11
, pp. 193-198
-
-
McKee, P.J.W.1
Blacklaw, J.2
Butler, E.3
Gillnam, R.A.4
Brodie, M.J.5
-
27
-
-
0018899537
-
Valproic acid and plasma levels of phenobarbital
-
Bruni J, Wilder BJ, Perchalski RJ, Hammond EJ, Villarreal HJ. Valproic acid and plasma levels of phenobarbital. Neurology 1980;30:94-7.
-
(1980)
Neurology
, vol.30
, pp. 94-97
-
-
Bruni, J.1
Wilder, B.J.2
Perchalski, R.J.3
Hammond, E.J.4
Villarreal, H.J.5
-
29
-
-
0023795094
-
Increased valproate serum concentrations upon carbamazepine cessation
-
Jann MW, Fidone GS, Israel MK, Bonadero P. Increased valproate serum concentrations upon carbamazepine cessation. Epilepsia 1988;29:578-81.
-
(1988)
Epilepsia
, vol.29
, pp. 578-581
-
-
Jann, M.W.1
Fidone, G.S.2
Israel, M.K.3
Bonadero, P.4
-
30
-
-
0018826355
-
Low serum valproic acid concentrations in epileptic patients on combination therapy
-
Reunanen MI, Luoma P, Myllylä VV, Hokkanen E. Low serum valproic acid concentrations in epileptic patients on combination therapy. Curr Ther Res 1980;28:456-62.
-
(1980)
Curr Ther Res
, vol.28
, pp. 456-462
-
-
Reunanen, M.I.1
Luoma, P.2
Myllylä, V.V.3
Hokkanen, E.4
-
31
-
-
0028063684
-
The effect of felbamate on valproate disposition
-
Wagner ML, Graves NM, Leppik IE, Remmel RP, Ward DL, Shumaker RC. The effect of felbamate on valproate disposition. Clin Pharmacol Ther 1994;56:494-502.
-
(1994)
Clin Pharmacol Ther
, vol.56
, pp. 494-502
-
-
Wagner, M.L.1
Graves, N.M.2
Leppik, I.E.3
Remmel, R.P.4
Ward, D.L.5
Shumaker, R.C.6
-
32
-
-
0001052466
-
Multiple-dose pharmaco-kinetics of topiramate in healthy male subjects
-
Doose DR, Scott VV, Margul BL, et al. Multiple-dose pharmaco-kinetics of topiramate in healthy male subjects [Abstract]. Epilepsia 1988;29:662.
-
(1988)
Epilepsia
, vol.29
, pp. 662
-
-
Doose, D.R.1
Scott, V.V.2
Margul, B.L.3
-
33
-
-
0021299630
-
Variability in level-dose ratio of valproale: Monotherapy versus polytherapy
-
Levy RH. Variability in level-dose ratio of valproale: monotherapy versus polytherapy. Epilepsia 1984;25(suppl 1):S10-3.
-
(1984)
Epilepsia
, vol.25
, Issue.SUPPL. 1
-
-
Levy, R.H.1
|