Characterization of calcineurin from Hymenolepis microstoma and H. diminuta and its interaction with cyclosporin A

Parasitology

Volumn 114, Issue 3, 1997, Pages 279-283

  Roberts, H C ^a   Sternberg, J M ^a   Chappell, L H ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

calcineurin; cyclophilin; cyclosporin; Hymenolepis spp.; parasites

Indexed keywords

CALCINEURIN; CYCLOPHILIN; CYCLOSPORIN A;

ANIMAL EXPERIMENT; ANTHELMINTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; HYMENOLEPIS DIMINUTA; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMINO ACID ISOMERASES; AMINO ACID SEQUENCE; ANIMALS; ANTHELMINTICS; CALCINEURIN; CALMODULIN-BINDING PROTEINS; CARRIER PROTEINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLOSPORINE; HYMENOLEPIS; MICE; MOLECULAR SEQUENCE DATA; PEPTIDES; PEPTIDYLPROLYL ISOMERASE; PHOSPHOPROTEIN PHOSPHATASE;

ANIMALIA; HYMENOLEPIS DIMINUTA; MAMMALIA; MICROSTOMA; RODENTOLEPIS MICROSTOMA; VERMES;

EID: 0030956246     PISSN: 00311820     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0031182096008190     Document Type: Article

References (23)

1. BELL, A., WERNLI, B. & FRANKLIN, R. M. (1994). Rules of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK-506 and rapamycin. Biochemical Pharmacology 48, 495 503.
2. BELL, A., ROBERTS, H. C. & CHAPPELL, L. H. (1996). The antiparasite effects of cyclosporin A: possible drug tarets and clinical applications. General Pharmacology 27, 000-000.
3. BRADFORD, M. M. (1976). A rapid and sensitive method for the quantification of microgram quantities of protein utilising the principle of protein-dye binding. Annals of Biochemistry 72, 248-254.
4. BREUDER, T., HEMENWAY, C. S., MOVVA, N. R., CARDENAS, M. E. & HEITMAN, J. (1994). Calcineurin is essential in cyclosporin A-sensitive and FK506-sensitive yeast strains. Proceedings of the National Academy of Sciences, USA 91, 5372-5376.
5. CHAPPELL, L. H. & WASTLING, J. M. (1992). Cyclosporin A: antiparasitic drug, modulator of the host-parasite relationship and immunosuppressant. Parasitology 105 (Suppl.), S25-S40.
6. CHAUDHURI, B., HAMMERLE, M. & FURST, P. (1995). The interaction between the catalytic A subunit of calcineurin and its autoinhibitory domain, in the yeast two-hybrid system, is disrupted by cyclosporin A and FK506. FEBS Letters 357, 221-226.
7. EASTLAKE, J. L., BRANFORD-WHITE, C. J. & WHISH, W. J. D. (1994). The distribution of calmodulin/calmodulin binding proteins in the rat tapeworm, Hymenolepis diminuta. Comparative Biochemistry and Physiology 108, 487-490.
8. ENZ, A., SHAPIRO, G., CHAPPUIS, A. & DATTLER, A. (1994). Nonradioactive assay for protein phosphatase 2B (calcineurin) activity using a partial sequence of the subunit of cAMP-dependent protein kinase as substrate. Analytical Biochemistry 216, 147-153.
9. FURLONG, S. T., THIBAULT, K. S. & ROGERS, R. A. (1992). Fluorescent phospholipids preferentially accumulate in sub-tegumental cells of schistosomula of Schistosoma mansoni. Journal of Cell Science 103, 823-830.
10. GAVERIAUX, C., BOESCH, D., JACHEZ, B., BOLLINGER, P., PAYNE, T. & LOOR, F. (1991). SDZ-PSC 833, a non-immunosuppressive cyclosporin analog is a very potent multidrug resistance modifier. Journal of Cellular Pharmacology 2, 225-234.
11. KE, H., ZHAO, Y., LUO, F., WEISSMAN, I. & FRIEDMAN, J. (1993). Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A. Proceedings of the National Academy Sciences, USA 90, 11850-11854.
12. KLEE, C. B. & COHEN, P. (1988). The calmodulin-regulated protein phosphatase. In Molecular Aspects of Cellular Regulation (ed. P. Cohen & C. B. Klee), pp. 225-245. Elsevier, Amsterdam.
13. KUNZ, J. & HALL, M. N. (1993). Cyclosporin A, FK506 and rapamycin: more than just immunosuppression. Trends in Biochemical Sciences 18, 334-338.
14. LAEMMLI, U. K. (1970). Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature, London 227, 680-685.
15. PAGE, A. P., LANDRY, D., WILSON, G. G. & CARLOW, C. K. S. (1995). Molecular characterisation of a cyclosporin A-insensitive cyclophilin from the parasitic nematode, Brugia malayi. Biochemistry 34, 11545-11550.
16. PARSONS, J. N., WIEDERRECHT, G. J., SALOWE, S., BURBAUM, J. J., ROKOSZ, L. L., KINCAID, R. L. & O'KEEFE, S. J. (1994). Regulation of calcineurin phosphatase activity and interaction with the FK506-FK506 binding protein complex. Journal of Biological Chemistry 269, 19610-19616.
17. PASTORINO, J. G., SNYDER, J. W., SERRONI, A., HOEK, J. B. & FARBER, J. L. (1993). Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition. Journal of Biological Chemistry 268, 13791-13798.
18. REMILLARD, S. P., LAI, E. Y., LEVY, Y. Y. & FULTON, C. (1995). A calcineurin-B-encoding gene expressed during differentiation of the amoeboflagellate Naegleria gruberi contains two introns. Gene 154, 39-45.
19. ROBERTS, H. C., STERNBERG, J. M. & CHAPPELL, L. H. (1995). Hymenolepis diminuta and H. microstoma: uptake of cyclosporin A and binding to parasite cyclophilin. Parasitology 111, 591-597.
20. SIKKINK, R., HADDY, A., MACKELVIE, S., MERTZ, P., LITWILLER, R. & RUSNAK, F. (1995). Calcineurin subunit interactions: mapping the calcineurin B binding domain on calcineurin A. Biochemistry 34, 8348-8356.
21. STEINKASSERER, A., HARRISON, R., BILLICH, A., HAMMERSCHMID, F., WERNER, G., WOLFF, B., PEICHL, P., PALFI, G., SCHNITZEL, W., MLYNAR, E. & ROSENWIRTH, B. (1995). Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus type 1 (HIV-1): interference with early and late events in HIV-1 replication. Journal of Virology 69, 814-824.
22. STEWART, A. A. & COHEN, P. (1988). Protein phosphatase 2B from rabbit skeletal muscle: a calcium-dependent, calmodulin-stimulated enzyme. Methods in Enzymology 159, 409-416.
23. WIEDERRECHT, G., LAM, E., HUNG, S., MARTIN, M. & SIGAL, N. (1993). The mechanism of action of FK506 and cyclosporin A. Annals of the New York Academy of Science 696, 9-19.