Evidence that expression of a mutated p53 gene attenuates apoptotic cell death in human gastric intestinal-type carcinomas in vivo

Japanese Journal of Cancer Research

Volumn 88, Issue 5, 1997, Pages 468-475

  Ishida, Masato ^a   Gomyo, Yoshihito ^a   Ohfuji, Satoshi ^a   Ikeda, Mitsuyuki ^a   Kawasaki, Hironaka ^a   Ito, Hisao ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

Apoptosis; Gastric carcinoma; p53; PCR SSCP; TUNEL

Indexed keywords

CYCLINE; DNA NUCLEOTIDYLEXOTRANSFERASE; PROTEIN BAX; PROTEIN P53;

ADENOCARCINOMA; APOPTOSIS; ARTICLE; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ETIOLOGY; GENE MUTATION; HUMAN; HUMAN CELL; IN VIVO STUDY; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; STOMACH CANCER; STOMACH CARCINOMA; TUMOR CELL;

EID: 0030956061     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1997.tb00405.x     Document Type: Article

References (43)

1. Stemmermann, G., Heffelfinger, S. C., Noffsinger, A., Hui, Y. Z., Miller, M. A. and Fenoglio, C. M. The molecular biology of esophageal and gastric cancer and their precursors: oncogenes, tumor suppressor genes, and growth factors. Hum. Pathol., 25, 968-981 (1994).
2. Yokozaki, H., Kuniyasu, H., Kitadai, Y., Nishimura, K., Todo, H., Ayhan, A., Yasui, W., Ito, H. and Tahara, E. p53 point mutations in primary human gastric carcinomas. J. Cancer Res. Clin. Oncol., 119, 67-70 (1992).
3. Tamura, G., Kihana, T., Nomura, K., Terada, M., Sugimura, T. and Hirohashi, S. Detection of frequent p53 gene mutations in primary gastric cancer by cell sorting and polymerase chain reaction single-strand conformation polymorphism analysis. Cancer Res., 51, 3056-3058 (1991).
4. Kim, J. H., Takahashi, T., Chiba, I., Park, J. G., Birrer, M. J., Roh, J. K., De Lee, H., Kim, J. P., Minna, J. D. and Gazdar, A. F. Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines. J. Natl. Cancer Inst., 83, 938-943 (1991).
5. Motozaki, T., Sakamoto, C., Matsuda, K., Suzuki, T., Konda, Y., Naakano, O., Wada, K., Uchida, T., Nishisaki, H. and Nagao, M. Missense mutations and a deletion of the p53 gene in human gastric cancer. Biochem. Biophys. Res. Commun., 182, 215-223 (1992).
6. Sano, T., Tsujino, T., Yoshida, K., Nakayama, H., Haruma, K., Ito, H., Nakamura, Y., Kajiyama, G. and Tahara, E. Frequent loss of heterozygosity on chromosomes 1q, 5q, and 17p in human gastric carcinomas. Cancer Res., 51, 2926-2931 (1991).
7. Gomyo, Y., Osaki, M., Kaibara, N. and Ito, H. Numerical aberration and point mutation of p53 gene in human gastric intestinal metaplasia and well-differentiated adenocarcinoma: analysis by fluorescence in situ hybridization (FISH). Int. J. Cancer, 66, 594-599 (1996).
8. Uchino, S., Noguchi, M., Ochiai, A., Saito, T., Kobayashi, M. and Hirohashi, S. p53 mutation in gastric cancer: a genetic model for carcinogenesis is common to gastric and colorectal cancer. Int. J. Cancer, 22, 759-764 (1993).
9. Yamada, Y., Yoshida, T., Hayashi, K., Sekiya, T., Yokota, J., Hirohashi, S., Nakatani, K., Nakano, H., Sugimura, T. and Terada, M. p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases. Cancer Res., 51, 5800-5805 (1991).
10. Uchino, S., Tsuda, H., Noguchi, M., Yokota, J., Terada, M., Saito, T., Kobayashi, M., Sugimura, T. and Hirohashi, S. Frequent loss of heterozygosity at the DCC locus in gastric cancer. Cancer Res., 52, 3099-3102 (1992).
11. Starzynska, T., Bromley, M., Ghosh, A. and Stern, P. L. Prognostic significance of p53 overexpression in gastric and colorectal carcinoma. Br. J. Cancer, 66, 558-562 (1992).
12. Kakeji, Y., Korenaga, D., Tsujitani, S., Baba, H., Anai, H., Maehara, Y. and Sugimachi, K. Gastric cancer with p53 overexpression has high potential for metastasising to lymph nodes. Br. J. Cancer, 67, 589-593 (1993).
13. Lowe, S. W., Ruley, H. E., Jack, T. and Housman, D. E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74, 957-967 (1993).
14. Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A. and Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature, 362, 847-849 (1993).
15. Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L. and Wyllie, A. H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature, 362, 849-852 (1993).
16. Symonds, H., Krall, L., Remington, L., Saenz Robles, M., Lowe, S., Jacks, T. and van Dyke, T. p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell, 78, 703-711 (1994).
17. Bardeesy, N., Beckwith, J. B. and Pelletier, J. Clonal expression and attenuated apoptosis in Wilms' tumors are associated with p53 gene mutations. Cancer Res., 55, 215-219 (1995).
18. Lauren, P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol. Microbiol. Scand., 64, 31-49 (1965).
19. Grundmann, E. and Schlake, W. Histological classification of gastric cancer from initial to advanced stage. Pathol. Res. Pract., 173, 260-274 (1982).
20. Gavrieli, Y., Sherman, Y. and Ben-Sasson, S. A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol., 119, 493-501 (1992).
21. Mattar, R., Yokozaki, H., Yasui, W., Ito, H. and Tahara, E. p53 gene mutations in gastric cancer cell lines. Oncology, 11, 7-12 (1992).
22. Tahara, E. Carcinogenesis and progression of human gastric cancer. Proc. Jpn. Soc. Pathol., 81, 21-49 (1992).
23. Baas, I. O., Mulder, J.-W. R., Offerhaus, G. J. A., Vogelstein, B. and Hamilton, S. An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms. J. Pathol., 172, 5-12 (1994).
24. Kikuchi-Yanoshita, R., Konishi, M., Ito, S., Seki, M., Tanaka, K., Maeda, Y., Iino, H., Fukayama, M., Koike, M. and Mori, T. Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients. Cancer Res., 52, 3965-3971 (1992).
25. Tsuda, H. and Hirohashi, S. Association among p53 gene mutation, nuclear accumulation of the p53 protein and aggressive phenotypes in breast cancer. Int. J. Cancer, 57, 498-503 (1994).
26. Esrig, D., Spruck, C. H. 3d., Nichols, P. W., Chaiwun, B., Steven, K., Groshen, S., Chen, S. C., Skinner, D. G., Jones, P. A. and Cote, R. J. p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer. Am. J. Pathol., 143, 1389-1397 (1993).
27. Lane, D. P. and Benchimol, S. p53: oncogene or anti-oncogene? Genes Dev., 4, 1-8 (1990).
28. Finlay, C. A., Hinds, P. W., Tan, T. H., Eliyahu, D., Oren, M. and Levine, A. J. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol. Cell. Biol., 8, 531-539 (1988).
29. D'Andrea, E., Baffa, R., Menin, C., Montagna, M., Rugge, M. and Chieco-Bianchi, L. TP53 gene mutations in gastric carcinoma detected by polymerase chain reaction/single-strand conformation polymorphism analysis of archival material. J. Cancer Res. Clin. Oncol., 121, 79-83 (1995).
30. Hayashi, K. and Yandell, D. W. How sensitive is PCR-SSCP? Hum. Mutat., 2, 338-346 (1993).
31. Shiao, Y.-H., Rugge, M., Correa, P., Lehmann, H. P. and Scheer, W. D. p53 alteration in gastric precancerous lesions. Am. J. Pathol., 144, 511-517 (1994).
32. Zhan, Q., Lord, K. A., Alamo, I. Jr., Hollander, M. C., Carrier, F., Ron, D., Kohn, K. W., Hoffman, B., Liebermann, D. A. and Fornace, A. J. Jr. The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth. Mol. Cell. Biol., 14, 2361-2371 (1994).
33. Canman, C. E., Gilmer, T. M., Coutts, S. B., Kasta, M. B. Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev., 9, 600-611 (1995).
34. Lowe, S. W., Jacks, T., Housman, D. E. and Ruley, H. E. Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc. Natl. Acad. Sci. USA, 91, 2026-2030 (1994).
35. Lane, D. P. p53, guardian of the genome. Nature, 358, 15-16 (1992).
36. Lowe, S. W., Bodis, S., McClatchey, A., Remington, L., Ruley, H. E., Fisher, D. E., Housman, D. E. and Jacks, T. p53 status and the efficacy of cancer therapy in vivo. Science, 266, 807-810 (1994).
37. Kobayashi, M., Watanabe, H., Ajioka, Y., Yoshida, M., Hitomi, Y. and Asakura, H. Correlation of p53 protein expression with apoptotic incidence in colorectal neoplasia. Virchows Arch., 427, 27-32 (1995).
38. Waldmann, T., Kinzler, K. W. and Vogelstein, B. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res., 55, 5187-5190 (1995).
39. El-Deiry, W. S., Harper, J. W., O'Connor, P. M., Veolculescu, V. E., Canman, C. E., Jackman, J., Pietenpol, J. A., Burrell, M., Hill, D. E., Wang, Y., Wiman, K. G., Mercer, W. E., Kastan, M. B., Kohn, K. W., Elledge, S. J., Kinzler, K. W. and Vogelstein, B. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res., 54, 1169-1174 (1994).
40. Jiang, H., Lin, J., Su, Z.-Z., Collart, F. R., Huberman, E. and Fisher, P. B. Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/ CIP1, expression in the absence of p53. Oncogene, 9, 3397-3406 (1994).
41. Steinman, R. A., Hoffman, B., Iro, A., Guillouf, C., Liebermann, D. A. and El-Houseini, M. E. Induction of p21 (WAF1/CIP1) during differentiation. Oncogene, 9, 3389-3396 (1994).
42. Michieli, P., Chedid, M., Lin, D., Pierce, J. H., Mercer, W. E. and Givol, D. Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res., 54, 3391-3395 (1994).
43. Sato, T., Hanada, M., Bodrug, S., Irie, S., Iwama, N., Boise, L. H., Thompson, C. B., Golemis, E., Fong, L., Wang, H.-G. and Reed, J. C. Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc. Natl. Acad. Sci. USA, 91, 9238-9242 (1994).