Reduced aggressive behaviour in mice with targeted disruption of the oxytocin gene

Journal of Neuroendocrinology

Volumn 9, Issue 5, 1997, Pages 363-368

  DeVries, A Courtney ^a,d   Young III, W Scott ^b   Nelson, Randy J ^c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d UNIVERSITY OF MARYLAND   (United States)

Author keywords

Agonistic behaviour; Genetic knock out; Octapeptide; Pituitary; Sensorimotor; Social behaviour

Indexed keywords

OXYTOCIN;

AGGRESSION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE DISRUPTION; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; SOCIAL BEHAVIOR;

EID: 0030956044     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.1997.t01-1-00589.x     Document Type: Article

References (24)

1. Pedersen CA, Jirikowski GF, Caldwell JD, Insel TR, eds. Oxytocin in maternal, sexual and social behavior. NY Acad Sci 1992; 652: 1-489.
2. Carter CS. Oxytocin and sexual behavior. Neurosci Biobehav Rev 1992; 16: 131-144.
3. Schumacher M, Corini H, Pfaff DW, McEwen BS. Behavioral effects of progesterone associated with rapid modulation of oxytocin receptors. Science 1990; 250: 691-694.
4. Winslow JT, Insel TR. Social status in pairs of male squirrel monkeys determines the behavioral response to central oxytocin administration. J Neurosci 1991; 11: 2032-2038.
5. Ferris CF, Foote KB, Meltser HM, Plenby, MG, Smith KL, Insel TR. Oxytocin in the amygdala facilitates maternal aggression. NY Acad Sci 1992; 652: 456-7.
6. Insel TR. Oxytocin-a neuropeptide for affiliation: evidence from behavioral, receptor autoradiographic, and comparative studies. Psychoneuroendocrinology 1992; 17: 3-35.
7. de Wied D, Diamant M, Fodor M. Central nervous system effects of the neurohypophyseal hormones and related peptides. Front Neuroendocr 1993; 14: 251-302.
8. Verbalis JG, Mangione MP, Stricker EM. Oxytocin produces naturiuresis in rats at physiological plasma concentrations Endocrinology 1991; 128: 1317-1322.
9. Young WS III, Shepard E, Amico J, Hennighausen L, Wagner K-U, LaMarca ME, McKinney C, Ginns EI. Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition. J Neuroendocr 1996; 8: 849-853.
10. Chou C.-L, DiGiovanni SR, Mejia R, Nielson S, Knepper MA. Oxytocin as an antidiuretic hormone: I Concentration dependence of action. Am J Physiol 1995; 269: F70-F77.
11. Argiolas A, Cessa GL. Central functions of oxytocin. Neurosci Biobehav Rev 1991; 15: 217-231.
12. Pedersen CA, Prange A. Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin. Proc Natl Acad Sci 1979; 76: 6661-6665.
13. Pedersen CA, Caldwell JD, Johnson MF, Fort SA, Prange AJ. Oxytocin antiserum delays onset of ovarian steroid-induced maternal behavior. Neuropeptides 1985; 6: 175-182.
14. Good M. Targeted deletion of neuronal nitric oxide: a step closer to understanding its functional significance. Trends Neurosci 1996; 19: 83-84.
15. Chen C, Rainnie DG, Greene RW, Tonegawa S. Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science 1994; 266: 291-294.
16. Saudou F, Amara DA, Diericht A, LeMeur M, Ramboz S, Segu L, Buhot MC, Hen, RCL. Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science 1994; 265: 1875-1878.
17. Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Muller U, Aguet M, Babinet, C. Shih JC. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 1995; 270: 1763-6.
18. Nelson RJ, Demas GE, Huang PL, Fishman MC, Dawson, VL, Dawson TM, Snyder, SH. Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature 1995; 78: 383-386.
19. Drago, F, Sarnyai Z, D'Agata V. The inhibition of oxytocin-induced grooming by a specific receptor antagonist. Physiol Behav 1991; 50: 533-536.
20. Lathe, R. Mice, gene targeting and behaviour: more than just genetic background. Trends Neurosci 1996; 19: 183-186.
21. Moran, TH, Reeves RH, Rogers D, Fisher E. Ain't misbehavin'-it's genetic. Nat Genet 1996; 12: 115-116.
22. Ferris F, Potegal M. Vasopressin receptor blockade in the anterior hypothalamus suppresses aggression in hamsters. Physiol Behav 1988; 44: 235-239.
23. Winslow, JT, Hastings N, Carter CS, Harbaugh CR, Insel TR. A role for central vasopressin in pair bonding in monogamous prairie voles. Nature 1994; 365: 545-548.
24. Ogawa S, Lubahan DB, Korach KS, Pfaff DW. Behavioral characterization of transgenic estrogen receptor knock-out male mice: sexual, aggressive and open-field behaviors. Endocrine Soc Abstr, 1995 P1-84.