Rescue of Drosophila engrailed mutants with a highly divergent mosquito engrailed cDNA using a homing, enhancer-trapping transposon

Development

Volumn 124, Issue 8, 1997, Pages 1531-1541

  Whiteley, Mary ^a   Kassis, Judith A ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

Drosophila; Engrailed; Enhancer trapping; Gene therapy; Mosquito; P element homing

Indexed keywords

COMPLEMENTARY DNA; DNA FRAGMENT;

ANIMAL CELL; ANOPHELES; ARTICLE; CHROMOSOME; CODON; CONTROLLED STUDY; DEVELOPMENT; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INSERTION; GENE MUTATION; GENE SEQUENCE; GENE THERAPY; GENETIC TRANSCRIPTION; MOSQUITO; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSPOSON;

AMINO ACID SEQUENCE; ANIMALS; ANOPHELES; DNA TRANSPOSABLE ELEMENTS; DROSOPHILA MELANOGASTER; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; GENES, HOMEOBOX; GENETIC ENGINEERING; HOMEODOMAIN PROTEINS; INSECT HORMONES; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; TRANSCRIPTION FACTORS;

ANIMALIA; ANOPHELES GAMBIAE;

EID: 0030955966     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Bellen, H. J., O'Kane, C. J., Wilson, C., Grossniklaus, U., Pearson, R. K. and Gehring, W. J. (1989). P-element-mediated enhancer detection: a versatile method to study development in Drosophila. Genes Dev. 3, 1288-1300.
2. Bier, E., Vaessin, H., Shepherd, K., Lee, K., McCall, K., Barbel, S., Ackerman, R., Carretto, T., E. Uemura, E., Grell, E., Jan, L. Y. and Jan, Y. N. (1989). Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector. Genes Dev. 3, 1273-1287.
3. Brown, S. J., Parrish, J. K. and Denell, R. E. (1994). Embryonic expression of the single engrailed gene of Tribolium. Dev. Genetics 15, 7-18.
4. Coleman, K. G., Poole, S. J., Weir, M. P., Soeller, W. C. and Kornberg, T. B. (1987). The invected gene of Drosophila: sequence analysis and expression studies reveal a close kinship to the engrailed gene. Genes Dev. 1, 19-28.
5. Dolecki, G. J. and Humphreys, T. (1988). An engrailed class homeobox gene in sea urchins. Gene 64, 21-31.
6. Drees B., Ali, Z., Soeller, W. C., Coleman, K. G., Poole, S. J.and Kornberg, T. (1987). The transcription unit of the Drosophila engrailed locus: an unusually small portion of a 70,000 bp gene. EMBO J. 6, 2803 -2809.
7. Fasano, J. and Kerridge, S. (1988). Monitoring positional information during oogenesis in adult Drosophila. Development 104, 245-253.
8. Fauvarque, M. O. and Dura, J. M. (1993). Polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila. Genes Dev. 7, 1508-1520.
9. Fjose, A., Eiken, G., Njolstad, P. R., Molven, A. and Hordvik, I. (1988). A zebrafish engrailed-like homeobox sequence expressed during embryogenesis. FEBS Lett. 231, 355-360.
10. Gustavson, E., Goldsborough, A. S., Ali, Z. and Kornberg, T. B. (1996). The Drosophila engrailed and invected genes: partners in regulation, expression and function. Genetics 142, 893-906.
11. Hama, C., Ali, Z. and Kornberg, T. B. (1990). Region-specific recombination and expression are directed by portions of the Drosophila engrailed promoter. Genes Dev. 4, 1079-1093.
12. Hanks, M., Wurst, W., Anson-Cartwright, L., Auerbach, A. B. and Joyner, A. L. (1995). Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science 269, 679-682.
13. Heemskerk, J., DiNardo, A., Kostriken, R. and O'Farrell, P. H. (1991) Multiple modes of engrailed regulation in the progression towards cell fate determination. Nature 352, 404-410.
14. Holland, P. W. and Williams, N. A. (1990). Conservation of engrailed-like homeobox sequences during vertebrate evolution. FEBS Lett. 277, 250-252.
15. Hudson, A., O'Connor, M., McCall, K. and Bender, W. (1995). P-element homing within the bithorax complex. A. Conf. Dros. Res. 36, 240A.
16. Hui, C., Matsuno, K., Ueno, K. and Suzuki, Y. (1992). Molecular characterization and silk gland expression of Bombyx engrailed and invected genes. Proc. Natl. Acad. Sci. USA 89, 167-171.
17. Joyner, A. L., Kornberg, T., Coleman, K. G., Cox, D. R., Martin, G. R. (1985). Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene. Cell 43, 29-37.
18. Joyner, A. L. and Martin, G. R. (1987). En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis. Genes Dev. 1, 29-38.
19. Judd, B. H. (1988). Transvection: allelic cross talk. Cell 53, 841-843.
20. Kamb, A., Weir, M., Rudy, B.,Varmus, H. and Kenyon, C. (1989). Identification of genes from pattern formation, tyrosine kinase and potassium channel families by DNA amplification. Proc. Natl. Acad. Sci USA 86, 4372-4376.
21. Kassis, J. A. (1990). Spatial and temporal control elements of the Drosophila engrailed gene. Genes Dev. 4, 433-443.
22. Kassis, J. A., Noll, E., Vansickle, E. P., Odenwald, W. F. and Perrimon, N. (1992). Altering the insertional specificity of a Drosophila transposable element. Proc. Natl. Acad. Sci. USA 89, 1919-1923.
23. Kassis, J.A. (1994). Unusual properties of regulatory DNA from the Drosophila engrailed gene: Three 'pairing-sensitive' sites within a 1.6-kb region. Genetics 136, 1025-1038.
24. Kornberg, T. (1981). Engrailed: a gene controlling compartment and segment formation in Drosophila. Proc. Natl. Acad. Sci. USA 78, 1095-1099.
25. Kuner, J. M., Nakanishi, M., Ali, Z., Drees, B., Gustavson, E., Theis, J., Kauvar, L., Kornberg, T. and O'Farrell, P. H. (1985). Molecular cloning of engrailed, a gene involved in the development of pattern in Drosophila melanogaster. Cell 42, 309-316.
26. Logan, C., Hanks, M. C., Noble-Topham, S., Nallainathan, D., Provart, N. J. and Joyner, A. L. (1992). Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions. Dev. Genet. 13, 345-358.
27. Lutz, B., Lu, H. C., Eichele, G., Miller, D. and Kaufman, T. C. (1996). Rescue of Drosophila labial null mutant by the chicken ortholog Hoxb-1 demonstrates that the function of Hox genes is phylogenetically conserved. Genes Dev. 10, 176-184.
28. Morata, G. and Lawrence, P. A. (1975). Control of compartment development by the engrailed gene in Drosophila. Nature 255, 614-617.
29. Muller, J., Gaunt, S. and Lawrence, P. A. (1995). Function of the Polycomb protein is conserved in mice and flies. Development 121, 2847-2852.
30. O'Kane, C. J., and Gehring, W. J. (1987). Detection in situ of genomic regulatory elements in Drosophila. Proc. Natl. Acad. Sci. USA 84, 9123-9127.
31. Patel, N. H., Martin-Blanco, E., Coleman, K. G., Poole, S. J., Ellis, M. C., Kornberg, T. and Goodman, C. S. (1989). Expression of engrailed proteins in arthropods, annelids, and chordates. Cell 58, 955-968.
32. Patel, N. H. (1994). Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes. In Methods in Cell Biology Vol. 44 (ed. Goldstein, L.S.B, and Fyrberg, E.), pp. 445-487. Academic Press: New York.
33. Pirrotta, V. (1988). Vectors for P-mediated transformation in Drosophila. In Vectors: A Survey of Molecular Cloning Vectors and Their Uses (eds. R. L. Rodriguez and D. T. Denhardt), pp. 437-456. Buttersworth, Boston.
34. Poole, S., Kauvar, L. M., Drees, B. and Kornberg, T. (1985). The engrailed locus of Drosophila: structural analysis of an embryonic transcript. Cell 40, 37-43.
35. Robertson, H. M., Preston., C. R., Phillis, R. W., Johnson-Schlitz, D. M., Benz, W. K., and Engels, W. R. (1988). A stable genomic source of P element transposase in Drosophila melanogaster. Genetics 118, 461-470.
36. Smith, S. T. and Jaynes, J. B. (1996). A conserved region of engrailed, shared among en-, gsc-, Nk1-, Nk2- and msh-class homeoproteins, mediates active transcriptional repression in vivo. Development 122, 3141-3150.
37. Spradling, A. (1986). P element-mediated transformation. In Drosophila: A Practical Approach, (ed. D. B. Roberts), pp. 175-195. IRL, Oxford.
38. Tautz, D. and Pfeifle, C. (1989). A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98, 81-85.
39. Tower, J., Karpen, G.H., Craig, N. and Spradling, A. C. (1993). Preferential transposition of Drosophila P elements to nearby chromosomal sites. Genetics 133, 347-359.
40. Walldorf, U., Fleig, R. and Gehring, W. J. (1989). Comparison of homeobox-containing genes of the honeybee and Drosophila. Proc. Natl. Acad. Sci. USA 86, 9971-9975.
41. Webster, P. J. and Mansour, T. E. (1992). Conserved classes of homeodomains in Schistosoma mansoni and early bilateral metazoan. Mech. Dev. 38, 25-32.
42. Wedeen, C. J. and Weisblat, D. A. (1991). Segmental expression of an engrailed-claas gene during early development and neurogenesis in an annelid. Development 113, 805-814.
43. Whiteley, M., Noguchi, P. D., Sensabaugh, S. M., W.F. Odenwald, W. F. and Kassis, J. A. (1992). The Drosophila gene escargot encodes a zinc finger motif found in snail-related genes. Mech. Dev. 36, 117-127.
44. Xue, L. and Noll, M. (1996). The functional conservation of proteins in evolutionary alleles and the dominant role of enhancers in evolution. EMBO J. 15, 3722-3731.
45. Zhang, P., and Spradling, A. C. (1993). Efficient and dispersed local P element transpositions from Drosophila females. Genetics 133, 361-373.
46. Zhang, S.-D., Kassis, J., Olde, B., Mellerick, D.M. and Odenwald, W. F. (1996). Pollux, a novel Drosophila adhesion molecule, belongs to a family of proteins expressed in plants, yeast, nematodes and man. Genes Dev. 10, 1108-1119.