Plasma nitric oxide metabolite in women with primary Raynaud's phenomenon and in healthy subjects

Clinical Physiology

Volumn 17, Issue 3, 1997, Pages 269-277

  Ringqvist, A ^c,d   Leppert, J ^a   Myrdal, U ^a   Ahlner, J ^b   Ringqvist, I ^a   Wennmalm, A ^c  

^a Västerås Hospital   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Body cooling; Circulation; Nitrate; Nitric oxide

Indexed keywords

NITRATE; NITRIC OXIDE;

ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CLINICAL ARTICLE; COLD CLIMATE; COLD EXPOSURE; CONTROLLED STUDY; FEMALE; FINGER; HUMAN; INDUCED HYPOTHERMIA; METABOLITE; PRIORITY JOURNAL; RAYNAUD PHENOMENON; SEASONAL VARIATION; SKIN BLOOD FLOW; SUMMER; SYMPTOM; TIME; TOE; VENOUS BLOOD; WINTER;

EID: 0030955809     PISSN: 01445979     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2281.1997.tb00006.x     Document Type: Article

References (17)

1. BEIDAIRA G. V., KIM D., BLASCHKE T. F. & HOFFMAN B. B. (1993) Venodilation in Raynaud's disease. Lancet, 342, 1451-1454.
2. BODE-BÖGER S. M., BÖGER R. H., SCHRÖDER E. P. & FRÖLICH J. C. (1994) Exercise increases systemic nitric oxide production in men. J Cardiovasc Risk, 1, 173-178.
3. Hu Z-W., MILLER J. W. & HOFFMAN B. B. (1994) Induction of enhanced release of endothelium-derived relaxing factor after prolonged exposure to α-adrenergic agonists: role in desensitization of smooth muscle contraction. J Cardiovasc Pharmacol, 23, 337-343.
4. IZZO J. L. JR, LARRABEE P. S., SANDER E. & LILLIS L. M. (1990) Hemodynamics of seasonal adaptation. Am J Hypertens, 3, 405-407.
5. JIA L., BONAVENTURA C., BONAVENTURA J. & STAMLER J. S. (1996) S-nitrosohemoglobin: a dynamic activity of blood involved in vascular control. Nature, 380, 221-226.
6. JUNGERSTEN L., EDLUND A., HAFSTRÖM L-O., KARLSSON L., PETTERSSON A-S. & WENNMALM Å. (1993) Plasma nitrate as an index of immune system activation in animals and man. J Clin Lab Immunol, 40, 1-4.
7. JUNGERSTEN L., EDLUND A., PETERSSON A-S. & WENNMALM A. (1996) Plasma nitrate as an index of nitric oxide formation in man: analyses of kinetics and confounding factors. Clin Physiol, 16, 369-379.
8. LEAF C. D., WISHNOK J. S. & TANNENBAUM S. R. (1990) Nitric oxide: the dark side. In: Nitric Oxide from L-Arginine: a Bioregulatory System (eds Moncada S. and Higgs E.A.), pp. 291-299. Elsevier, New York.
9. LEPPERT J., RINGQVIST Å., AHLNER J., MYRDAL U., SÖRENSSEN S. & RINGQVIST I. (1995) Cold exposure increases cyclic guanosine monophosphate in healthy women but not in women with Raynaud's phenomenon. J Intern Med, 237, 493-498.
10. MONCADA S., PALMER R. M. J. AND HIGGS E. A. (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev, 43, 109-142.
11. NIELSEN S. L. & LASSEN N. A. (1977) Measurement of digital blood pressure after local cooling. J Appl Physiol, 43, 907-912.
12. STAMLER J. S., JARAKI O., OSBORNE J., SIMON D. I., KEANEY J., VITA J., SINGEL D., VALERI C. R. & LOSCALZO J. (1992) Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci USA, 89, 7674-7677.
13. TAKAHASHI H., NAKANISHI T., NISHIMURA M., TANAKA H. & YOSHIMURA M. (1992) Measurements of serum levels of nitrate in men and women: implications of endothelial-derived relaxing factor in blood pressure regulation and atherosclerosis. J Cardiovasc Pharmacol, 20 (Suppl. 12), 214-216.
14. WENNMALM Å., BENTHIN G., EDLUND A., JUNGERSTEN L., KIELER-JENSEN N., LUNDIN S., NATHORST WESTFELDT U., PETERSSON A-S. & WAAGSTEIN F. (1993) Metabolism and excretion of nitric oxide in humans. Circ Res, 73, 1121-1127.
15. WESTFELT U. N., BENTHIN G., LUNDIN S., STENQVIST O. & WENNMALM Å. (1995) Conversion of inhaled nitric oxide to nitrate in man. Br J Pharmacol, 114, 1621-1624.
16. WINLAW D. S., SMYTHE G. A., KEOGH A. M., SCHYVENS C. G., SPRATT P. M. & MACDONALD P. S. (1994) Increased nitric oxide production in heart failure. Lancet, 344, 373-374.
17. ZANZINGER J., CZACHURSKI J. & SELLER H. (1994) Inhibition of sympathetic vasoconstriction is a major principle of vasodilation by nitric oxide in vivo. Circ Res, 75, 1073-1077.