Hindshaker, a novel myelin mutant showing hypomyelination preferentially affecting the spinal cord

Journal of Neurocytology

Volumn 26, Issue 8, 1997, Pages 557-566

  King, H ^a   McCulloch, M C ^a   Barrie, J A ^a   Kyriakides, E ^a   Beechey, C V ^a,b   Cattanach, B M ^a,b   Griffiths, I R ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN; MYELIN PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CONTROLLED STUDY; MOUSE; MYELIN DEFICIENCY; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; SPINAL CORD DISEASE; SPONTANEOUS MUTATION; TREMOR;

ANIMALS; AUTORADIOGRAPHY; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HINDLIMB; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MICE; MICE, INBRED C3H; MICE, NEUROLOGIC MUTANTS; MUTATION; MYELIN BASIC PROTEINS; MYELIN PROTEOLIPID PROTEIN; MYELIN SHEATH; PHENOTYPE; RNA, MESSENGER; SPINAL CORD; SPINAL CORD DISEASES; TREMOR;

ANIMALIA; MURINAE;

EID: 0030955351     PISSN: 03004864     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015486508111     Document Type: Article

References (31)

1. BEECHEY, C. V. (1993) A new spontaneous neurological mutant. Mouse Genome 91, 114-15.
2. BJARTMAR, C., HILDEBRAND, C. & LOINDER K. (1994) Morphological heterogeneity of rat oligodendrocytes: electron microscopic studies on serial sections. Glia 11, 233-44.
3. BOISON, D. & STOFFEL, W. (1994) Distribution of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice. Proceedings of the National Academy of Sciences USA 91, 11709-13.
4. BUTT, A. M., IBRAHIM, M., RUGE, F. M. & BERRY, M. (1995) Biochemical subtypes of oligodendrocyte in the anterior medullary velum of the rat as revealed by the monoclonal antibody Rip. Glia 14, 185-97.
5. DUNCAN, I. D. (1987) Abnormalities of myelination of the central nervous system associated with congenital tremor. Journal of Veterinary Internal Medicine 1, 10-23.
6. DUNCAN, I. D. (1990) Dissection of the phenotype and genotype of the X-linked myelin mutants. Annals of the Neiv York Academy of Sciences 605, 110-21.
7. EBERSOLE, T. A., CHEN, Q., JUSTICE, M. J. & ARTZT, K. (1996) The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins. Nature Genetics 12, 260-5.
8. 0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons. Cell 71, 565-76.
9. GRIFFITHS, I. R. (1996) Myelin mutants: model systems to study normal and abnormal myelination. BioEssays 18, 789-97.
10. GRIFFITHS, I. R., MITCHELL, L. S., MCPHILEMY, K., MORRISON, S., KYRIAKIDES, E. & BARRIE, J. A. (1989) Expression of myelin protein genes in Schwann cells. Journal of Neurocytology 18, 345-52.
11. GRIFFITHS, I. R., SCOTT, I., MCCULLOCH, M. C., BARRIE, J. A., MCPHILEMY, K. & CATTANAH, B. M. (1990) Rumpshaker mouse: a new X-linked mutation affecting myelination: evidence for a defect in PLP expression. Journal of Neurocytology 19, 273-83.
12. KLUGMANN, M., SCHWAB, M., PÜHLHOFER, A., SCHNEIDER, A., ZIMMERMANN, F., GRIFFITHS, I. R. & NAVE, K. (1997) Assembly of CNS myelin in the absence of proteolipid protein. Neuron 18, 59-70.
13. KNAPP, P. E., SKOFF, R. P. & REDSTONE, D. W. (1986) Oligodendroglial cell death in jimpy mice: an explanation for the myelin deficit. Journal of Neuroscience 6, 2813-22.
14. KNAPP, P. E. & SKOFF, R. P. (1993) Jimpy mutation affects astrocytes: Lengthening of the cell cycle in vitro. Developmental Neuroscience 15, 31-6.
15. KORNEGAY, J. N., GOODWIN, M. A. & SPYRIDAKIS, L. K. (1987) Hypomyelination in a Weimaraner dog. Acta Neuropathologica (Berlin) 72, 394-401.
16. LAWSON, H. A., GRIFFITHS, I. R., MONTAGUE, P. & CATTANACH, B. M. (1996) Hindshaker: a novel myelin mutant shows differential hypomyelination in the CNS. Neuropathology and Applied Neurobiology 22, 144 (Abstract).
17. LUNN, K. F., FANARRAGA, M. L. & DUNCAN, I. D. (1995) Myelin mutants: New models and new observations. Microscopic Research Techniques 32, 183-203.
18. 0)-deficient mice show myelin degeneration in peripheral nerves characteristic of inherited human neuropathies. Nature Genetics 11, 281-6.
19. MITCHELL, L. S., GILLESPIE, C. S., MCALLISTER, F., FANARRAGA, M., KIRKHAM, D., KELLY, B., BROPHY, P. J., GRIFFITHS, I. R., MONTAGUE, P. & KENNEDY, P. G. E. (1992) Developmental expression of the major myelin protein genes in the CNS of the X-linked hypomyelinating mutant rumpshaker. Journal of Neuroscience Research 33, 205-17.
20. NAVE, K.-A. (1994) Neurological mouse mutants and the genes of myelin. Journal of Neuroscience Research 38, 607-12.
21. NAVE, K.-A. (1996) Myelin-specific genes and their mutations in the mouse. In Glial Cell Development. Basic Principles and Clinical Relevance (edited by JESSEN, K. R. and RICHARDSON, W. D.), pp. 141-64. Oxford: Bios.
22. PERRY, V. H., HUME, D. A. & GORDON, S. (1985) Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Neuroscience 15, 313-26.
23. PIDDLESDEN, S. J., LASSMANN, H., ZIMPRICH, F., MORGAN, B. P. & LININGTON, C. (1993) The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement. American Journal of Patholology 143, 555-64.
24. REMAHL, S. & HILDEBRAND, C. (1990) Relation between axons and oligodendroglial cells during initial myelination. I. The glial unit. Journal of Neurocytology 19, 313-28.
25. SKOFF, R. P. (1976) Myelin deficit in the jimpy mouse may be due to cellular abnormalities in astroglia. Nature 264, 560-2.
26. STERNBERGER, L. A., HARDY, P. H. J., CUCULIS, J. J. & MEYER, H. G. (1970) The unlabelled antibodyenzyme method of immunocytochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. Journal of Histochemistry and Cytochemistry 18, 315-33.
27. SUZUKI, K. & NAGARA, H. (1982) Quaking mouse: vacuolar degeneration of spinal roots. Acta Neuropathologica (Berlin) 58, 269-74.
28. SUZUKI, K. & ZAGOREN, J. C. (1997) Quaking mouse: an ultrastructural study of the peripheral nerves, Journal of Neurocytology 6, 71-84.
29. 0 protein in Golgi complex membranes and myelin of developing rat Schwann cells. Journal of Cell Biology 90, 1-6.
30. TRAPP, B. D., MOENCH, T., PULLEY, M., BARBOSA, E., TENNEKOON, G. I. & GRIFFIN, J. W. (1987) Spatial segregation of mRNA encoding myelin-specific proteins. Proceedings of the National Academy of Sciences USA 84, 7773-7.
31. WILLIAMS, M. A. (1977) Stereological techniques. In Practical Methods in Electron Microscopy. Vol. 6. Quantitative Methods in Biology (edited by G LAUERT, A. M.), pp. 5-84. Amsterdam: North Holland.