Excitatory amino acid receptor antagonists: Resolution, absolute stereochemistry, and pharmacology of (S)- and (R)-2 -amino-2-(5- tert-butyl- 3-hydroxyisoxazol-4-yl) acetic acid (ATAA)

Chirality

Volumn 9, Issue 5-6, 1997, Pages 529-536

  Johansen, Tommy N ^a   Frydenvang, Karla ^a   Ebert, Bjarke ^a   Madsen, Ulf ^a   Krogsgaard Larsen, Povl ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Absolute stereochemistry; AMPA receptor antagonist; Chiral HPLC; Diastereomeric salt resolution; Enantiomeric purity; NMDA receptor antagonist; X ray crystallography

Indexed keywords

2 AMINO 2 (5 TERT BUTYL 3 HYDROXYISOXAZOL 4 YL)ACETIC ACID; 4 (3 PHOSPHONOPROPYL) 2 PIPERAZINECARBOXYLIC ACID; AMPA RECEPTOR ANTAGONIST; EXCITATORY AMINO ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NEUROPHARMACOLOGY; NEUROTRANSMISSION; PRIORITY JOURNAL; RECEPTOR BINDING; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BINDING, COMPETITIVE; CEREBRAL CORTEX; CORPUS CALLOSUM; CRYSTALLOGRAPHY, X-RAY; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID ANTAGONISTS; INDICATORS AND REAGENTS; ISOXAZOLES; KAINIC ACID; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; RADIOLIGAND ASSAY; RATS; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; STEREOISOMERISM; TRITIUM;

EID: 0030955204     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1997)9:5/6<529::AID-CHIR20>3.0.CO;2-P     Document Type: Article

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