Derivatized oxopiperazine rings from amino acids

Tetrahedron Letters

Volumn 38, Issue 21, 1997, Pages 3679-3682

  Bhatt, Ulhas ^a   Mohamed, Nazim ^a   Just, George ^a   Roberts, Edward ^b  

^a MCGILL UNIVERSITY   (Canada)

^b Astra Research Centre Montreal   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PIPERAZINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; IN VITRO STUDY; REACTION ANALYSIS;

EID: 0030954191     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00726-0     Document Type: Article

References (16)

1. Adjunct Professor, Department of Chemistry, McGill University.
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9. 13C NMR and MS (EI) showed complete absence of 1,4 reduction product even when 2 equivalents of hydride ion was added.
10. (a) For a recent review see Carpino, L. A.; Beyermann, M.; Wenschuh, H.; Bienert, M., Acc. Chem. Res. 1996, 29, 268-274.
11. (b) Carpino, L.A.; Mansour, E.-S. M. E.; Sadat-Aalaee, D.; J. Org. Chem. 1991, 56, 2611-2614.
12. 13C NMR) prior to the coupling step.
13. +, 277 (69.8), 217 (51.8), 213 (89.1).
14. Fukuyama, T.; Jow, C. K.; Cheung, M., Tetrahedron Lett. 1995, 36, 6373-6374.
15. +, 275 (13.3), 229 (51.0), 157 (35.8).
16. During the completion of this manuscript, we came across the following publication where similar compounds were prepared by a different route. Pohlmann, A.; Schanen, V.; Guillaume, D.; Quirion, J.-C.; Husson, H.-P., J. Org. Chem. 1997, 62, 1016-1022.