The use of toads (Bufo regularis) in a new biological assay for screening chemicals or drugs which induce leukaemia in man

Oncology Reports

Volumn 4, Issue 3, 1997, Pages 657-660

  El Mofty, M M ^a   Abdel Meguid, N E ^a   Sadek, I A ^a   Essawy, A E ^a   Abdel Aleem, E A ^a  

^a Alexandria University Faculty Of Science   (Egypt)

Author keywords

7,12 dimethylbenz(a)anthracine; adriamycin; Bufo regularis; leukaemia

Indexed keywords

CARCINOGEN; DIMETHYLBENZ[A]ANTHRACENE; DOXORUBICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENICITY; CONTROLLED STUDY; FEMALE; LEUKEMOGENESIS; MALE; NONHUMAN; PRIORITY JOURNAL; TOAD;

EID: 0030954082     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.4.3.657     Document Type: Article

References (24)

1. Bonadonna G, Monfardini S, De Lena M and Fosati F: Clinical evaluation of adriamycin, a new antitumor antibiotic. Br Med J 3: 503-506, 1969.
2. Bonadonna G, Monfardini S, De Lena M, Fosati Balanic F and Beretta G: Phase I and preliminary phase II evaluation of adriamycin (NSC, 123-127). Cancer Res 30: 2572-2582, 1970.
3. Ogawa T: Studies on endoscopic local injection of an anticancer agent into experimental canine stomach cancer. Kitakant Med J 35: 463-467, 1985.
4. Dimarco A, Gaetani M and Scarpinata B: Adriamycin, a new antibiotic with antitumor activity. Cancer Chemother Rep 53: 33-37, 1969.
5. Sandberg JS, Housden FL, Di Marco A and Goldin A: Comparison of the antileukaemic effect in mice of adriamycin (NSC, 123-127) with daunomycin (NSC 82151). Cancer Chemother Rep 54: 1-7, 1970.
6. Blum RH and Carter SK: Adriamycin: a new anthracyline drug with significant clinical activity. Ann Intern Med 80: 249-259, 1974.
7. Sieber SM and Adamson RH: Toxicity of anti neoplastic agents in man - chromosomal aberrations, antifertility effects, congenital malformations and carcinogenic potential. Adv Cancer Res 22: 57-155, 1975.
8. Marquardt H, Philips FS and Sternberg SS: Tumorigenicity in vivo and induction of malignant transformation and mutagenesis in cell culture by adriamycin and daunomycin. Cancer Res 36: 2065-2069, 1976.
9. Bertazzoli C, Chieli T and Solcia E: Different incidence of breast carcinomas or fibroadenomas in daunomycin-treated rats. Experientia 27: 1209-1210, 1971.
10. Philips FS, Gilladoga A, Marquardt H, Sternberg SS and Vidal RR: Some observations on the toxicity of adriamycin. Cancer Chemother Rep 6: 177-181, 1975.
11. Chambers SK, Chopyk RL, Chambers JT, Schwartz PE and Duffy TP: Development of leukaemia after doxorubicin and cisplatin treatment for ovarian cancer. Cancer 64: 2459-2461, 1989.
12. Marquardt H: Induction of malignant transformation and mutagenesis in cell culture by cancer chemotherapeutic agents. Cancer 40: 1930-1934, 1977.
13. El-Mofty MM, Khudoley VV, Sakre SA, Osman SI and Toulan BA: Adriamycin induced neoplastic lesions in the Egyptian toad Bufo regularis. Oncology 48: 171-174, 1991.
14. El-Mofty MM, Khudoley VV, Essawy AE and Abdel-Kerim HM: Induction of hepatocellular carcinomas in the Egyptian toad Bufo regularis by an antifungal drug (griseofulvin). Oncology 50: 267-269, 1993.
15. Sadek IA and Abdul-Salam F: Effect of dietary fat on toad liver tumor induced by DMBA: ultrastructural studies. Histol Histopathol 9: 423-426, 1994.
16. Duryee WR, Long ME, Taylor HC, McKelway WP and Ehrman RL: Human and amphibian neoplasm compared. Tumors in frogs and human beings are strikingly similar in cytological characteristics. Science 131: 276-280, 1960.
17. El-Mofty MM, Abdel Medguid NE and Essawy AE: Pathological changes of the blood cells in griseofulvin treated toads. Oncol Rep 2: 167-170, 1995.
18. Ghadially FN: Diagnostic Electron Microscopy of Tumors. 2nd edition. Butterworths and Co. (Publishers) Ltd., 1985.
19. Dickersin GR: Diagnostic electron microscopy. A Text/Atlas. Igaku-Shoin Medical Publishers Inc. Tokyo, 1988.
20. Komiyama A, Ogawa M, Eurenins K and Spicer SS: Unusual cytoplasmic incuclusions in blast cells in acute leukaemia. Arch Pathol Lab Med 100: 590-594, 1976.
21. Kalayama I and Schneider GB: Further ultrastructural characterization of hairy cells of leukaemic reticulo endotheliosis. Am J Pathol 86: 163, 1977.
22. Brunning RD and Parkin J: Ribosomes-lamella complexes in neoplastic hematopoietic cells. Am J Pathol 79: 565-578, 1975.
23. Chandra S and Stefani SS: Ultrastructure of granulofilamentous bodies in pathologic spleen and lymph node. J Ultrastrct Res 64: 148, 1978.
24. Yoshida H and Fukunishi R: Mammary tumors and leukaemia in female Sprague Dawley rats evoked by a series of intragastric administration of 7,12-dimethylbenz(a)anthracene. Gann 68: 237-239, 1977.