Single and repeated dose toxicity studies of meloxicam by oral administration in minipigs

Pharmacometrics

Volumn 53, Issue 3, 1997, Pages 197-212

  Yabe, Tomokuni ^a   Honma, Masato ^a   Katsuki, Shoji ^a   Wiegleb, Jürgen ^b   Luetzen, Lenhard ^b   Pueschner, Hubert ^b   Lehmann, Horst ^b  

^a NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

(minipigs); Meloxicam; Nonsteroidal anti inflammatory drug (NSAID); Toxicity

Indexed keywords

MELOXICAM; NONSTEROID ANTIINFLAMMATORY AGENT; UH AC 62XX; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG TOXICITY; FEMALE; GRANULATION TISSUE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; SHOCK; STOMACH ULCER; SWINE; VOMITING;

EID: 0030954010     PISSN: 03008533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Engelhardt, G., Homma, D., Utzmann, R. and Schnitzlet, C. (1995): Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance, Inflamm. Res., 44, 423-433.
2. Lehmann, H., Baumeister, M., Luetzen, L. and Wiegleb, J. (1996): Meloxicam: A toxicological overview, Inflammopharmacology, 4, 1051-123.
3. Main, I.H.M. and Whittle, B.J.R. (1974): Prostaglandins and prostaglandin synthetase inhibitors in gastrointestinal function and disease. In: Prostaglandin Synthetase Inhibitors, Robinson, H.J. and Vane, J.R. (eds.), p. 363-372. Raven Press, New York.
4. Price, A.H. and Fletcher, M. (1990): Mechanisms of NSAID-induced gastroenteropathy, Drugs, 40, 1-11.
5. Whittle, B.J.R. (1977): Antisecretory prostaglandins and gastric mucosal erosions in the rat. In: Prostaglandins and Thromboxanes, Berti, F., Samuelsson, B. and Velo, G.P. (eds.), p. 315-322, Plenum Press, New York and London.
6. Whittle, B.J.R. and Vane, J.R. (1984): A biochemical basis for the gastrointestinal toxicity of non-steroidal antirheumatoid drugs. Arch. Toxicol., 7, 315-322.