Adverse effects of corticosteroid therapy for COPD: A critical review

Chest

Volumn 111, Issue 3, 1997, Pages 732-743

  McEvoy, Charlene E ^a   Niewoehner, Dennis E ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

adverse effects; chronic obstructive pulmonary disease; corticosteroids

Indexed keywords

BECLOMETASONE; BECLOMETASONE DIPROPIONATE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCITRIOL; CALCIUM ION; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; OSTEOCALCIN; PARATHYROID HORMONE; PREDNISOLONE; PREDNISONE;

ADRENAL INSUFFICIENCY; ASTHMA; CHRONIC BRONCHITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; COUGHING; CUSHING SYNDROME; DIABETES MELLITUS; DYSPHONIA; GASTROINTESTINAL HEMORRHAGE; GLUCOSE INTOLERANCE; HUMAN; HYPERTENSION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE DEFICIENCY; INFECTION; INHALATIONAL DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MENTAL DISEASE; META ANALYSIS; MULTICENTER STUDY; MYOPATHY; ORAL DRUG ADMINISTRATION; OSTEOPOROSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; WHEEZING;

EID: 0030953914     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.111.3.732     Document Type: Article

References (95)

1. Callahan C, Dittus R, Katz B. Oral corticosteroid therapy for patients with stable chronic obstructive pulmonary disease: a meta-analysis. Ann Intern Med 1991; 114:216-23
2. Albert R, Martin T, Lewis S. Controlled clinical trial of methylprednisolone in patients with chronic bronchitis and acute respiratory insufficiency. Ann Intern Med 1980; 92: 753-58
3. Emerman CL, Connors AF, Lukens TW, et al. A randomized controlled trial of methylprednisolone in the emergency treatment of acute exacerbations of COPD. Chest 1989; 95:563-67
4. Rostom A, Mink S, Hebert PC, et al. The long-term efficacy ol methylprednisolone in the emergency treatment of acute exacerbations of COPD. Chest 1994; 106(suppl):161S
5. Niewochner D, Erbland M. Systemic corticosteroids in COPD - an unresolved clinical dilemma. Chest 1996; 110: 867-69
6. Watson A, Lim TK, Joyce H, et al. Failure of inhaled corticosteroids to modify bronchoconstrictor or bronchodilator responsiveness in middle-aged smokers with mild airflow obstruction. Chest 1992; 101:350-55
7. Weir D, Gove R, Robertson A, et al. Corticosteroid trials in non-asthmatic chronic airflow obstruction: a comparison of oral prednisolone and inhaled beclomethasone dipropionate. Thorax 1990; 45:112-17
8. Kerstjens H, Brand P, Hughes M, et al. A comparison of bronchodilator therapy with and without inhaled corticosteroid therapy for obstructive airways disease. N Engl J Med 1992; 327:1413-19
9. Engel T, Heinig J, Modsen O, et al. A trial of inhaled budesonide on airway responsiveness in smokers with chronic bronchitis. Eur Respir J 1989; 2:935-39
10. Auffarth B, Postma D, Monchy JD, et al. Effects of inhaled budesonide on spirometric values, reversibility, airway responsiveness and cough threshold in smokers with chronic obstructive lung disease. Thorax 1991; 46:372-77
11. David D, Grieco M, Cushman P Jr. Adrenal glucocorticoids after 20 years: a review of their clinically relevant consequences. J Chron Dis 1970; 22:637-711
12. Smyllie H, Connolly C. Incidence of serious complications of corticosteroid therapy in respiratory disease. Thorax 1968; 23:571-81
13. Lieberman P, Patterson K, Kunske K. Complications of long-term steroid therapy for asthma. J Allergy Clin Immunol 1972; 49:329-36
14. Toogood J, Jennings B, Greenway R, et al. Candidiasis and dysphonia complicating beclomethasone treatment of asthma. J Allergy Clin Immunology 1980; 2:145-53
15. Williams A, Baghat M, Stableforth D, et al. Dysphonia caused by inhaled steroids: recognition of a characteristic laryngeal abnormality. Thorax 1983; 38:813-21
16. Shim C, Williams MH Jr. Cough and wheezing from beclomethasone aerosol. Chest 1987; 91:207-09
17. Toogood J, Jennings B, Baskerville J, et al. Dosing regimen of budesonide and occurrence of oropharyngeal complications. Eur J Respir Dis 1984; 65:35-44
18. Miyamoto T, Yoshida T, Osawa N, et al. Adrenal response and side reactions after long-term corticosteroid therapy in bronchial asthma. Ann Allergy 1972; 30:587-94
19. Tuft L, Marks A, Channick B. Long-term corticosteroid therapy in chronic intractable asthmatic patients. Ann Allergy 1971; 29:287-93
20. Schlaghecke R, Kornely K, Santen R, et al. The effect of long-term glucocorticoid therapy on pituitary-adrenal responses to exogenous corticotropin-releasing hormone. N Engl J Med 1992; 326:226-30
21. Brown P, Blundell G, Greening A, et al. Hypothalamo-pituitary-adrenal axis suppression in asthmatics inhaling high dose corticosteroids. Respir Med 1991; 85:501-10
22. Ninan T, Reid I, Carter P, et al. Effects of high doses of inhaled corticosteroids on adrenal function in children with severe persistent asthma. Thorax 1993; 48:599-602
23. Axelrod L. Glucocorticoid therapy. Medicine 1976; 55:39-65
24. Kehlet H, Binder G. Adrenocortical function and clinical course during and after surgery in unsupplemented glucocorticoid-treated patients. Brit J Anaesth 1973; 45:1043-48
25. Wong J, Black P. Acute adrenal insufficiency associated with high dose inhaled steroids. BMJ 1992; 304:1415
26. Cushing H. The basophil adenomas of the pituitary body and their clinical manifestations. Bull Johns Hopkins Hosp 1932; 50:137-95
27. Seeman K, Wagner H, Offord K, et al. Differential effects of endocrine dysfunction on the axial and appendicular skeleton. J Clin Invest 1982; 69:1302-09
28. Meeran K, Hattersley A, Burrin J, et al. Oral and inhaled corticosteroids reduce bone formation as shown by plasma osteocalcin levels. Am J Respir Crit Care Med 1995; 151: 333-36
29. Hahn T, Halstead L, Teitelbaum S, et al. Altered mineral metabolism in glucocorticoid induced osteopenia. J Clin Invest 1979; 64:655-65
30. Bikle D, Halloran B, Fong L, et al. Elevated 1,25-dihydroxyvitamin D levels in patients with chronic obstructive pulmonary disease treated with prednisone. J Clin Endocrinol Metab 1993; 76:456-61
31. Seeman K, Melton LM III, O'Fallon W, et al. Risk factors for spinal osteoporosis in men. Am J Med 1983; 75:977
32. Daniell H. Osteoporosis of the slender smoker: vertebral compression fractures and loss of metacarpal cortex in relation to postmenopansal cigarette smoking and lack of obesity. Arch Intern Med 1976; 136:298
33. Sinaki M. Exercise and physical therapy. In: Riggs B, Melton LM III, eds. Osteoporosis: etiology, diagnosis. New York: Raven Press, 1988; 457-69
34. Praet J, Peretz A, Rozenberg S, et al. Risk of osteoporosis in men with chronic bronchitis. Osteoporosis Int 1992; 2:257-61
35. Hall G, Spector T, Delmas P. Markers of bone metabolism in postmenopausal women with rheumatoid arthritis. Arthritis Rheum 1995; 38:902-06
36. Laan RFJM, van Riel PLCM, van de Putte LBA, et al. Low-dose prenidsone induces rapid reversible axial bone loss in patients with rheumatoid arthritis. Ann Intern Med 1993; 119:963-68
37. Conn H, Poynard T. Corticosteroids and peptic ulcer: metaanalysis of adverse events during steroid therapy. J Intern Med 1994; 236:619-32
38. Beid D, Nicoll J, Smith M, et al. Corticosteroids and bone mass in asthma: comparisons with rheumatoid arthritis and polymyalgia rheumatica. BMJ 1986; 293:1463-66
39. Reid I, Heap S. Determinants of vertebral mineral density in patients receiving long-term glucocorticoid therapy. Arch Intern Med 1990; 150:2545-48
40. Brandli D, Golde C, Greenwald M, et al. Glucocorticoid-induced osteoporosis: a cross-sectional study. Steroids 1991; 56:518-23
41. Guyatt G, Webber C, Mewa A, et al. Determining causation - a case study: adrenocorticosteroids and osteoporosis. J Chrom Dis 1984; 37:343-52
42. Adinoff A, Hollister J. Steroid-induced fractures and bone loss in patients with asthma. N Engl J Med 1983; 309:265-68
43. Ali N, Capewell S, Ward M. Bone turnover during high dose inhaled corticosteroid treatment. Thorax 1991; 46:160-64
44. Pouw E, Prummel M, Oosting H, et al. Beclomethasone inhalation decreases serum osteocalcin concentrations. BMJ 1991; 302:627-28
45. Kerstjens HAM, Postma DS, van Doormaal JJ, et al. Effects of short term and long term treatment with inhaled corticosteroids on bone metabolism in patients with airways obstruction. Thorax 1994; 49:652-56
46. Ip M, Lam K, Yam L, et al. Decreased bone mineral density in premenopausal asthma patients receiving long-term inhided steroids. Chest 1994; 105:1722-27
47. Packe G, Douglas J, McDonald A, et al. Bone density in asthmatic patients taking high dose inhaled beclomethasone dipropionate and intermittent systemic corticosteioids. Thorax 1992; 47:414-17
48. Conn H, Blitzer B. Nonassociation of adrenocorticosteroid therapy and peptic ulcer. N Engl J Med 1976; 294:473-79
49. Messer J, Keitman D, Sacks H, et al. Association of adrenocorticosteroid therapy and peptic-ulcer disease. N Engl J Med 1983; 309:21-4
50. Piper J, Ray W, Daugherty J, et al. Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs. Ann Intern Med 1991; 114:735-40
51. Carson J, Strom B. Schinnar R, et al. The low risk of upper gastrointestinal bleeding in patients dispensed corticosteroids. Am J Med 1991; 91:223-27
52. Program TBCDS. Acute adverse reactions in prednisone in relation to dosage. Clin Pharmacol Ther 1972; 13:694-98
53. Connett C, Lenney W. Inhaled budesonide and behavioral disturbances. Lancet 1991; 228:634-35
54. Meysboom H. Budesonide and psychotic side effects. Ann Intern Med 1988; 109:683
55. Lewis L, Cochrane G. Psychosis in child inhaling budesonide. Lancet 1983; 2:634
56. Cupps T, Fanci A. Corticosteroid mediated immunoregulation in man. Immunol Rev 1982; 65:133-55
57. Frey B, Walker C, Frey FJ, et al. Pharmacokinetics and pharmacodynamics of three different prednisone prodrugs: effect on circulation lymphocyte subsets and function. J Immunol 1984; 133:2479-87
58. Skerrett S, Niederman M, Fein A. Respiratory infections and acute lung injury in systemic illness. Clin Chest Med 1989; 10:469-502
59. Klaustermeyer WB, Gianos ME, Kurohara ML, et al. IgG subclass deficiency associated with corticosteroids in obstructive lung disease. Chest 1992; 102:1137-42
60. Stuck AE, Minder CE, Frey FJ. Risk of infectious complications in patients taking glucocorticosteroids. Rev Infect Dis 1989; 11:954-63
61. Blaiss M, Herrod H, Crawford L, et al. Beclomethasone dipropionate aerosol: hematologic and immunologic effects. Ann Allergy 1982; 48:210-14
62. Horton DJ, Spector SL. Clinical pulmonary tuberculosis in an asthmatic patient using a steroid aerosol. Chest 1977; 71: 540-42
63. Frank A, Dash C. Inhaled beclomethasone dipropionate in acute infectious of the respiratory tract. Respiration 1985; 48:122-26
64. Olefsky J, Kimmerling G. Effects of glucocorticoids on carbohydrate metabolism. Am J Med Sci 1976; 271:202-10
65. Kruszynska Y, Greenstone M, Home P, et al. Effect of high dose inhaled beclomethasone dipropionate on carbohydrate and lipid metabolism in normal subjects. Thorax 1987; 42: 881-84
66. Turpeinen M, Sorva R Juntunen-Backman K. Changes in carbohydrate and lipid metabolism in children with asthma inhaling budesonide. J Allergy Clin Immnnol 1991; 88:384-89
67. Fancourt C, Ebden P, McNally P. The effects of high dose (2,000 micrograms/day) inhaled beclomethasone dipropionate (Becloforte) on glucose tolerance in diet controlled elderly diabetic subjects. Eur Respir J 1988; 1(suppl 2): 196s
68. Ebden P, McNally P, Samanta A, et al. The effects of high dose inhaled beclomethasone dipropionate on glucose and lipid profiles in normal and diet controlled diabetic subjects. Respir Med 1989; 83:289-91
69. Kiviranta K, Turpeinen M. Effect of 8 months of inhaled beclomethasone dipropionate and budesonide on carbohydrate metabolism in adults with asthma. Thorax 1993; 48: 974-78
70. Perkoff G, Silber R, Tyler F, et al. Studies in disorders of muscle: XII. Myopathy due to the administration of therapeutic amounts of 17-hydrocorticosteroids. Am J Med 1959; 26:891-98
71. Ruff R, Endocrine myopathies, In: Engel A, Banke B, eds. Myology. New York: McCraw-Hill. 1986; 1871-1906
72. Wilcox P, Hards J, Bockhold K, et al. Pathologic changes and contractile properties of the diaphragm in corticosteroid myopathy in hamsters: comparison to peripheral muscle. Am J Respir Cell Mol Biol 1989; 1:191-98
73. Askari A, Vignos P, Moskowitz K. Steroid myopathy in connective tissue disease. Am J Med 1976; 61:485-92
74. Smith B. Histological and Histochemical changes in the muscles of rabbits given the corticosteroid triamcinolone. Neurology 1964; 14:857-63
75. Decramer M, Stas K. Corticosteroid-induced myopathy involving respiraton muscles in patients with chronic obstructive pulmonary disease or asthma. Am Rev Respir Dis 1992; 146:800-02
76. Bowyer S, LaMothe M. Hollister J. Steroid myopathy: incidence and detection in a population with asthma. J Allergy Clin Immunol 1985; 76:234-42
77. Mak V, Bugler J, Spiro S. Sternomastoid muscle fatigue and twitch maximum relaxation rate in patients with steroid-dependent asthma. Thorax 1993; 48:979-84
78. Picado C, Fiz J, Montserrat J, et al. Respiratory and skeletal muscle function in steroid-dependent bronchial asthma. Am Rev Respir Dis 1990; 141:14-20
79. Zanotti E, Corsico R, Rampulla C, et al. Effect of long-term therapy with oral steroid on respiratory muscle function and ventilatory drive. Monaldi Arch Chest Dis 1993; 48:16-22
80. Capewell S, Reynolds S, Shuttleworth D, et al. Purpura and dermal thinning associated with high dose inhaled corticosteroids. BMJ 1990; 300:1548-51
81. Mak V, Melchor R, Spiro S. Easy bruising as a side-effect of inhaled corticosteroids. Eur Respir J 1992; 5:1068-74
82. Whitworth J. Mechanisms of glucocorticoid-induced hypertension. Kidney Int 1987; 31:1213-24
83. Jackson S, Beevers D, Myers K. Does long-term low-close corticostoroid therapy cause hypertension? Clin Sci 1981; 61:381-83s
84. Black R, Oglesby R, von Sallmann L, et al. Posterior snbcapsular cataracts induced by corticosteroids in patients with rheumatoid arthritis. JAMA 1960; 174:166-71
85. Castrow F. Atopic cataracts versus steroid cataracts. J Am Acad Dermatol 1981; 5:64-6
86. David D, Berkowitz J. Ocular effects of topical and systemic corticosteroids. Lancet 1969; 1:149-51
87. Giles C, Mason G, Duff I, et al. The association of cataract formation and systemic corticosteroid therapy. JAMA 1962; 182:719-22
88. Bihari M, Grossman B. Posterior subcapsular cataracts related to long-term corticosteroid treatment in children. Am J Dis Child 1968; 116:604-08
89. Crews S. Posterior subcapsular lens opacities in patients on long-term corticosteroid therapy. BMJ 1963; 53:1644
90. Urban R Jr, Collier E. Corticosteroid-induced cataracts. Surv Ophthalmol 1986; 31:102-10
91. Toogood J, Markov A, Baskerville J, et al. Association of ocular cataracts with inhaled and oral steroid therapy during long-term treatment of asthma. J Allergy Clin Immunol 1993; 91:571-79
92. Karim A, Thompson G, Jacob T. Steroid aerosols and cataract formation. BMJ 1989; 299:918
93. Fraunfelder F, Meyer S. Posterior subcapsular cataracts associated with nasal or inhalational corticosteroids. Am J Ophthalmol 1990; 109:489-90
94. Allen M, Ray S, Leitch A, et al. Steroid aerosols and cataract formation. BMJ 1989; 299:432-33
95. Hill A. The environment and disease: association or causation? Proc R Soc Med 1965; 58:295-300