Both hypothyroidism and hyperthyroidism enhance low density lipoprotein oxidation

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 10, 1997, Pages 3421-3424

  Sundaram, Vidya ^a   Hanna, Atef N ^a   Koneru, Lata ^a   Newman, H A I ^a   Falko, James M ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b 491 McCampbell Hall ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; CLINICAL ARTICLE; EUTHYROIDISM; FEMALE; HEART DISEASE; HUMAN; HYPERTHYROIDISM; HYPOTHYROIDISM; LIPID OXIDATION; LIPOPROTEIN BLOOD LEVEL; MALE; PRIORITY JOURNAL; THYROID FUNCTION TEST;

ADULT; AGED; COPPER; DRUG RESISTANCE; FEMALE; HUMANS; HYPERTHYROIDISM; HYPOTHYROIDISM; LIPOPROTEINS; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; OXIDATION-REDUCTION; REFERENCE VALUES; TIME FACTORS;

ANGINA;

EID: 0030953351     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.10.3421     Document Type: Article

References (22)

1. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witzum JC. 1989 Beyond cholesterol. N Engl J Med. 320:14:915-424.
2. Reaven PD, Witzum JL. 1995 The role of oxidation of LDL in atherogenesis. Endocrinologist. 5:44-54.
3. Althaus B, Staub J, Leche A, Oberhansli A, Stahelin H. 1988 LDL/HDL changes in subclinical hypothyroidism: possible risk factors for coronary heart disease. Clin Endocrinol (Oxf). 28:157-163.
4. Caron P, Calazel C, Parra HJ, Hoff M, Louvet J. 1990 Decreased HDL cholesterol in subclinical hypothyroidism: the effect of L-thyroxine therapy. Clin Endocrinol (Oxf). 33:519-523.
5. Abrams J, Grundy S. 1981 Cholesterol metabolism in hypothyroidism and hyperthyroidism in man. J Lipid Res. 22:323-338.
6. Valdemarsson S, P H, Nilsson-Ehle P. 1982 Reversal of decreased hepatic lipase and lipoprotein lipase activities after treatment of hypothyroidism. Eur J Clin Invest. 12:423-428.
7. Thompson G, Soutar A, Spengel F, Jadhav A, Gavigan S, Myant NB. 1981 Defects of receptor-mediated low density lipoprotein catabolism in homozygous familial hypercholesterolemia and hypothyroidism in vivo. Proc Natl Acad Sci USA. 78:2591-2595
8. Chait A, Bierman E, Albers J. 1979 Regulatory role of triiodothyronine in the degradation of low density lipoprotein by cultured human skin fibroblasts. J Clin Endocrinol Metab. 48:887-889.
9. Kinlaw WB. 1995 Thyroid disorders and cholesterol: identifying the realm of clinical relevance. Endocrinologist. 5:148-155.
10. Fernandez V, Barrientos X, Kipreos K, Valenzuela A, Videla LA. 1985 Superoxide radical generation, NADPH oxidase activity, and cytochrome P-450 content of rat liver microsomal fractions in an experimental hyperthyroid state: relation to lipid peroxidation. Endocrinology. 117:496-501.
11. Hanna AN, Feller DR, Witiak DT, Newman HA. 1993 Inhibition of low density lipoprotein oxidation by thyronines and probucol. Biochem Pharmacol. 45:753-762.
12. Hanna AN, Titterington LC, Lantry LE, Stephens RE, Newman HAI. 1995 Thyronines and probucol inhibition of human capillary endothelial cell-induced low density lipoprotein oxidation. Biochem Pharmacol. 50:1627-1633.
13. Havel R, Eder H, Bragdon J. 1995 The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest. 34:1345-1353.
14. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951 Protein measurement with the Folin phenol reagent. J Biol Chem. 193:265-275.
15. Markwell MAK, Haas SM, Bieber LL, Tolbert NE. 1978 A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal Biochem. 87:206-210.
16. Noble R. 1968 Electrophoretic separation of plasma lipoproteins in agarose gel. J Lipid Res. 9:693-700.
17. Steinbrecher UP, Parthasarathy S, Leake D, Witztum JR, Steinberg D. 1984 Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc Natl Acad Sci USA. 81:3883-3887.
18. Friedewald WT, Levy RI, Fredrickson DS. 1972 Estimation of concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem. 18:499-502.
19. Winer B. 1971 Statistical principles in experimental design. New York: McGraw-Hill.
20. Benvenga S, Gregg R, Robbins J. 1988 Binding of thyroxine hormones to human plasma lipoproteins. J Clin Endocrinol Metab. 67:6-16.
21. Benvenga S, Cahnman H, Robbins J. 1990 Localization of the thyroxine binding sites in apolipoprotein B-100 of human low density lipoproteins. Endocrinology. 127:2241-2246.
22. Benvenga S, Robbins J. 1990 Enhancement of thyroxine entry into low density lipoprotein (LDL) receptor-competent fibroblasts by LDL: an additional mode of entry of thyroxine into cells. Endocrinology. 126:933-941.