메뉴 건너뛰기




Volumn 25, Issue 1-2, 1997, Pages 23-35

Inactivation of cyclin-dependent kinase inhibitor genes and development of human acute leukemias

Author keywords

9p21 chromosomal alterations; Cell cycle; Human leukemias; P16(INK4A) gene; Tumor suppressor genes

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR;

EID: 0030952947     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199709042493     Document Type: Review
Times cited : (15)

References (90)
  • 1
    • 0024473604 scopus 로고
    • G1 events and regulation of cell proliferation
    • Pardee, A. B. (1989). G1 events and regulation of cell proliferation. Science, 246, 603-608.
    • (1989) Science , vol.246 , pp. 603-608
    • Pardee, A.B.1
  • 2
    • 0029119740 scopus 로고
    • Cell cycle control in mammalian cells: Role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs)
    • Grana, X. and Reddy, E. P. (1995). Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene, 11, 211-219.
    • (1995) Oncogene , vol.11 , pp. 211-219
    • Grana, X.1    Reddy, E.P.2
  • 3
    • 0027083108 scopus 로고
    • Activation of human cyclin-dependent kinases in vitro
    • Desai, D., Gu, Y. and Morgan, D. O. (1992). Activation of human cyclin-dependent kinases in vitro. Mol. Biol. Cell., 3, 571-582.
    • (1992) Mol. Biol. Cell. , vol.3 , pp. 571-582
    • Desai, D.1    Gu, Y.2    Morgan, D.O.3
  • 4
    • 0027007963 scopus 로고
    • Role of phosphorylation in p34CDC2 activation
    • Solomon, M. J., Lee, T. and Kirschner, M. W. (1992). Role of phosphorylation in p34CDC2 activation. Mol. Biol. Cell., 3, 12-27.
    • (1992) Mol. Biol. Cell. , vol.3 , pp. 12-27
    • Solomon, M.J.1    Lee, T.2    Kirschner, M.W.3
  • 5
    • 0027938207 scopus 로고
    • Ordering S phase and M phase in the cell cycle
    • Nurse, P. (1994). Ordering S phase and M phase in the cell cycle. Cell, 79, 547-50.
    • (1994) Cell , vol.79 , pp. 547-550
    • Nurse, P.1
  • 6
    • 0028171292 scopus 로고
    • G1 phase progression: Cycling on cue
    • Sherr, C. J (1994). G1 phase progression: cycling on cue. Cell, 79, 551-5.
    • (1994) Cell , vol.79 , pp. 551-555
    • Sherr, C.J.1
  • 7
    • 0027967944 scopus 로고    scopus 로고
    • Rules to replicate by
    • Heichman, K. A. and Roberts, J. M. Rules to replicate by. Cell, 79, 557-62.
    • Cell , vol.79 , pp. 557-562
    • Heichman, K.A.1    Roberts, J.M.2
  • 9
    • 0027938209 scopus 로고
    • Cyclins and Cancer II: Cyclin D and CDK inhibitors. Come of age
    • Hunter, T. and Pines, J. (1994). Cyclins and Cancer II: cyclin D and CDK inhibitors. Come of age. Cell, 79, 573-82.
    • (1994) Cell , vol.79 , pp. 573-582
    • Hunter, T.1    Pines, J.2
  • 10
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R. A. (1995). The retinoblastoma protein and cell cycle control Cell, 81, 323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 11
    • 0028139463 scopus 로고
    • The retinoblastoma tumor suppressor protein
    • Wang, J. Y. J., Knudsen, E. S. and Welch, P. J. (1994). The retinoblastoma tumor suppressor protein. Adv Cancer Res., 64, 25-85.
    • (1994) Adv Cancer Res. , vol.64 , pp. 25-85
    • Wang, J.Y.J.1    Knudsen, E.S.2    Welch, P.J.3
  • 12
    • 0026526437 scopus 로고
    • E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
    • Nevins, J. R. (1992). E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science, 258, 424-429.
    • (1992) Science , vol.258 , pp. 424-429
    • Nevins, J.R.1
  • 13
    • 0028267869 scopus 로고
    • DRTF1/E2F: An expanding family of heterodimeric transcription factors implicated in cell-cycle control
    • LaThangue, N. B. (1994). DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci., 19, 108-114.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 108-114
    • Lathangue, N.B.1
  • 14
    • 0026459047 scopus 로고
    • D-type cyclins associated with multiple protein kinases and the DNA replication and repair factor PCNA
    • Xiong, Y., Zhang, H. and Beach, D. (1992). D-type cyclins associated with multiple protein kinases and the DNA replication and repair factor PCNA Cell, 71, 505-14.
    • (1992) Cell , vol.71 , pp. 505-514
    • Xiong, Y.1    Zhang, H.2    Beach, D.3
  • 17
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K. and Elledge, S. (1993). The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 75, 805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.5
  • 18
    • 0027731971 scopus 로고
    • Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
    • Gu, Y., Turck, C. W. and Morgan, D. O. (1993). Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature, 366, 707-710.
    • (1993) Nature , vol.366 , pp. 707-710
    • Gu, Y.1    Turck, C.W.2    Morgan, D.O.3
  • 19
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DMA synthesis using an expression screen
    • Noda, A., Ning, Y., Venable, S. F., Pereira-Smith, O. M. and Smith, J. R. (1994). Cloning of senescent cell-derived inhibitors of DMA synthesis using an expression screen. Exp. Cell. Res., 211, 90-98.
    • (1994) Exp. Cell. Res. , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 20
    • 0029031949 scopus 로고
    • The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells
    • Jiang, H., Lin, J., Su, Z. Z., Herlyn, M., Kerbel, R. S., Weissman, B. E., Welch, D. R. and Fisher, P. B. (1995). The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells. Oncogene, 10, 1855-1864.
    • (1995) Oncogene , vol.10 , pp. 1855-1864
    • Jiang, H.1    Lin, J.2    Su, Z.Z.3    Herlyn, M.4    Kerbel, R.S.5    Weissman, B.E.6    Welch, D.R.7    Fisher, P.B.8
  • 22
    • 0028363519 scopus 로고
    • P27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
    • Toyoshima, H. and Hunter, T. (1994). p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell, 78, 67-74.
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 23
    • 0028988158 scopus 로고
    • KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution
    • KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes and Dev., 9, 639-649.
    • (1995) Genes and Dev. , vol.9 , pp. 639-649
    • Lee, M.-H.1    Reynisdottir, I.2    Massagué, J.3
  • 26
    • 0028220204 scopus 로고
    • P53-Dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
    • Dulic, V., Kaufmann, W. K., Wilson, S. J., Tisty, T. D., Lees, E., Harper, J W., Elledge, S. J. and Reed, S. I. (1994). p53-Dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell, 76, 1013-1023.
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufmann, W.K.2    Wilson, S.J.3    Tisty, T.D.4    Lees, E.5    Harper, J.W.6    Elledge, S.J.7    Reed, S.I.8
  • 27
    • 0028365708 scopus 로고
    • Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21
    • Li, Y., Jenkins, C. W., Nichols, M. A. and Xiong, Y. (1994). Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. Oncogene, 9, 2261-2268.
    • (1994) Oncogene , vol.9 , pp. 2261-2268
    • Li, Y.1    Jenkins, C.W.2    Nichols, M.A.3    Xiong, Y.4
  • 28
    • 0027970713 scopus 로고
    • DNA damage triggers a prolonged p53-dependent G1 arrest and long term induction of Cipl in normal human fibroblasts
    • Di Leonardo, A., Linke, S. P., Clarkin, K. and Wahl, G. M (1994). DNA damage triggers a prolonged p53-dependent G1 arrest and long term induction of Cipl in normal human fibroblasts. Genes Dev., 8, 2540-2551.
    • (1994) Genes Dev. , vol.8 , pp. 2540-2551
    • Di Leonardo, A.1    Linke, S.P.2    Clarkin, K.3    Wahl, G.M.4
  • 29
    • 0028063456 scopus 로고
    • Mechanism of regulation of WAF1/Cip1 gene expression in human breast carcinoma: Role of p53-dependent and independent signal transduction pathway
    • Sheikh, M. S., Li, X.-S., Chen, J.-C., Shao, Z.-M., Ordonez, J. V. and Fontana, J. A. (1994). Mechanism of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathway. Oncogene, 9, 3407-3415.
    • (1994) Oncogene , vol.9 , pp. 3407-3415
    • Sheikh, M.S.1    Li, X.-S.2    Chen, J.-C.3    Shao, Z.-M.4    Ordonez, J.V.5    Fontana, J.A.6
  • 31
    • 0028985518 scopus 로고
    • P53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation
    • Zhang, W., Grasso, L., McClain, C. D., Gambel, A. M., Cha, Y., Travali, S., Deisseroth, A. B. and Mercer, W. E. (1995). p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation. Cancer Res., 55, 668-674.
    • (1995) Cancer Res. , vol.55 , pp. 668-674
    • Zhang, W.1    Grasso, L.2    McClain, C.D.3    Gambel, A.M.4    Cha, Y.5    Travali, S.6    Deisseroth, A.B.7    Mercer, W.E.8
  • 33
    • 0027987170 scopus 로고
    • Induction of differentiation in human promyelocitic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53
    • Jiang, H., Lin, J., Su, Z -Z., Collart, F. R., Huberman, E. and Fisher, P. B. (1994). Induction of differentiation in human promyelocitic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53. Oncogene, 9, 3397-3406.
    • (1994) Oncogene , vol.9 , pp. 3397-3406
    • Jiang, H.1    Lin, J.2    Su, Z.Z.3    Collart, F.R.4    Huberman, E.5    Fisher, P.B.6
  • 35
    • 0028352434 scopus 로고
    • The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
    • Waga, S., Hannon, G., Beach, D. and Stillman, B. (1994). The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature, 369, 574-578.
    • (1994) Nature , vol.369 , pp. 574-578
    • Waga, S.1    Hannon, G.2    Beach, D.3    Stillman, B.4
  • 36
    • 0027981476 scopus 로고
    • Cdk-interacting protein-1 [Cip1, Waf1] directly dinds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase δ holoenzyme
    • Flores-Rozas, H., Kelman, Z., Dean, Pan, Z.-Q., Harper, J. W., Elledge, S. J., O'Donnel, M. and Hurwitz, J. (1994). Cdk-interacting protein-1 [Cip1, Waf1] directly dinds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase δ holoenzyme. Proc. Natl. Acad. Sci. U S.A., 91, 8655-8659.
    • (1994) Proc. Natl. Acad. Sci. U S.A. , vol.91 , pp. 8655-8659
    • Flores-Rozas, H.1    Kelman, Z.2    Dean Pan, Z.-Q.3    Harper, J.W.4    Elledge, S.J.5    O'Donnel, M.6    Hurwitz, J.7
  • 37
    • 0028875086 scopus 로고
    • Evidence for different modes of action of cyclin-dependent kinase inhibitors: P15 and p16 bind to kinases. p21 and p27 bind to cyclins
    • Hall, M., Bates, S. and Peters, G. (1995). Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases. p21 and p27 bind to cyclins. Oncogene, 11, 1581-1588.
    • (1995) Oncogene , vol.11 , pp. 1581-1588
    • Hall, M.1    Bates, S.2    Peters, G.3
  • 38
    • 0029153609 scopus 로고
    • Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta
    • Reynisdottir, I., Polyak, K., Iavarone, A. and Massague, J. (1995). Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev., 9, 1831-45.
    • (1995) Genes Dev. , vol.9 , pp. 1831-1845
    • Reynisdottir, I.1    Polyak, K.2    Iavarone, A.3    Massague, J.4
  • 39
    • 0028941963 scopus 로고
    • Transforming growth factor beta-induced activation of cyclin E-cdk2 kinase and down-regulation of p27Kip1 in C3H 10T1/2 mouse fibroblasts
    • Ravitz, M. J., Yan, S., Herr, K. D. and Wenner, C. E. (1995). Transforming growth factor beta-induced activation of cyclin E-cdk2 kinase and down-regulation of p27Kip1 in C3H 10T1/2 mouse fibroblasts. Cancer Res., 55, 1413-1416.
    • (1995) Cancer Res. , vol.55 , pp. 1413-1416
    • Ravitz, M.J.1    Yan, S.2    Herr, K.D.3    Wenner, C.E.4
  • 40
    • 0028229732 scopus 로고
    • Inactivation of Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes
    • Firpo, E. J., Koff, A., Solomon, M. J. and Roberts, J. M. (1994). Inactivation of Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes. Mot. Cell. BioL, 14, 4889-4901.
    • (1994) Mot. Cell. BioL , vol.14 , pp. 4889-4901
    • Firpo, E.J.1    Koff, A.2    Solomon, M.J.3    Roberts, J.M.4
  • 42
  • 43
    • 0029024015 scopus 로고
    • Role of the Ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
    • Pagano, M., Tam, S. W., Theodoras, A. M., Beer-Romero, P., Del Sal, G., Chau, V., Yew, P. R., Draetta, G. F. and Rolfe, M. (1995). Role of the Ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science, 269, 692-695.
    • (1995) Science , vol.269 , pp. 692-695
    • Pagano, M.1    Tam, S.W.2    Theodoras, A.M.3    Beer-Romero, P.4    Del Sal, G.5    Chau, V.6    Yew, P.R.7    Draetta, G.F.8    Rolfe, M.9
  • 44
    • 0002949161 scopus 로고
    • A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano, M., Hannon, G. J. and Beach, D. (1993). A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature, 266, 122-126.
    • (1993) Nature , vol.266 , pp. 122-126
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 45
    • 0028275733 scopus 로고
    • Deletion of the cyclin-dependent kinase 4 inhibitor gene in multiple human cancers
    • Nobon, T., Miura, K., Wu, A., Luis, K., Takabashi, K. and Carson, D. A. (1994). Deletion of the cyclin-dependent kinase 4 inhibitor gene in multiple human cancers. Nature, 368, 753-6.
    • (1994) Nature , vol.368 , pp. 753-756
    • Nobon, T.1    Miura, K.2    Wu, A.3    Luis, K.4    Takabashi, K.5    Carson, D.A.6
  • 47
    • 0029401615 scopus 로고
    • INK4 gene inactivation in the development of human acute lymphoblastic leukemia
    • INK4 gene inactivation in the development of human acute lymphoblastic leukemia. Haematologica, 80, 562-573.
    • (1995) Haematologica , vol.80 , pp. 562-573
    • Delia Ragione, F.1    Mercurio, C.2    Iolascon, A.3
  • 48
    • 0028168242 scopus 로고
    • INK4B is a potential effector of TGF - Induced cell cycle arrest
    • INK4B is a potential effector of TGF - induced cell cycle arrest. Nature, 371, 257-260.
    • (1994) Nature , vol.371 , pp. 257-260
    • Hannon, G.J.1    Beach, D.2
  • 51
    • 0028918388 scopus 로고
    • Novel INK4 proteins, p19, p18. are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
    • Hirai, H., Roussel, M. F., Kato, J.-Y., Ashmun, R. A. and Sherr, C. J. (1995). Novel INK4 proteins, p19, p18. are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol Cell. Biol., 15, 2672-2681.
    • (1995) Mol Cell. Biol. , vol.15 , pp. 2672-2681
    • Hirai, H.1    Roussel, M.F.2    Kato, J.-Y.3    Ashmun, R.A.4    Sherr, C.J.5
  • 52
    • 0028886364 scopus 로고
    • Unrestricted cell cycling and cancer
    • Strauss, M., Lukas, J. and Bartek, J. (1995). Unrestricted cell cycling and cancer. Nature Medicine, 1, 1245-1246.
    • (1995) Nature Medicine , vol.1 , pp. 1245-1246
    • Strauss, M.1    Lukas, J.2    Bartek, J.3
  • 57
    • 0028338514 scopus 로고
    • Frequent somatic mutation of the MTS1/CDK41 (multiple tumor suppressor/cyclin-dependent kinase inhibitor) gene in esophageal squamous cell carcinoma
    • Mori, T., Miura, K., Aoki, T., Nishihira, T., Mori, S. and Nakamura, Y. (1994). Frequent somatic mutation of the MTS1/CDK41 (multiple tumor suppressor/cyclin-dependent kinase inhibitor) gene in esophageal squamous cell carcinoma. Cancer Res., 54, 3396-3397.
    • (1994) Cancer Res. , vol.54 , pp. 3396-3397
    • Mori, T.1    Miura, K.2    Aoki, T.3    Nishihira, T.4    Mori, S.5    Nakamura, Y.6
  • 58
    • 0028652269 scopus 로고
    • CDKN2 (p16:MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastoma
    • Schimdt, E. E., Ichimura, K., Reifenberger, G. and Collins, V. P. (1994). CDKN2 (p16:MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastoma. Cancer Res., 54, 6321-6324.
    • (1994) Cancer Res. , vol.54 , pp. 6321-6324
    • Schimdt, E.E.1    Ichimura, K.2    Reifenberger, G.3    Collins, V.P.4
  • 60
    • 0028875205 scopus 로고
    • Methylation of the 5′CpG Island of the p16/CDKN2 tumor suppressor gene in normal and transformed human cells correlates with gene silencing
    • Gonzales-Zulueta, M., Bender, C. M., Yang, A. S., Nguyen, T., Beart, R. W., Van Tornout, J. M. and Jones, P. A. (1995). Methylation of the 5′CpG Island of the p16/CDKN2 tumor suppressor gene in normal and transformed human cells correlates with gene silencing. Cancer Res., 55, 4531-4535.
    • (1995) Cancer Res. , vol.55 , pp. 4531-4535
    • Gonzales-Zulueta, M.1    Bender, C.M.2    Yang, A.S.3    Nguyen, T.4    Beart, R.W.5    Van Tornout, J.M.6    Jones, P.A.7
  • 63
    • 0029011539 scopus 로고
    • 5′CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E., Burger, P. C., Baylin, S. B. and Sidransky, D. (1995). 5′CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers. Nature Medicine, 1, 686-692.
    • (1995) Nature Medicine , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5    Burger, P.C.6    Baylin, S.B.7    Sidransky, D.8
  • 64
    • 0028897307 scopus 로고
    • Homozygous deletions of the multiple tumor suppressor gene 1 in the progression of human astrocytoma
    • Walker, D. G., Duan, W., Popovic, E. A., Kaye, A H., Tomlinson, F. H and Lavin, M. (1995). Homozygous deletions of the multiple tumor suppressor gene 1 in the progression of human astrocytoma. Cancer Res., 55, 20-25.
    • (1995) Cancer Res. , vol.55 , pp. 20-25
    • Walker, D.G.1    Duan, W.2    Popovic, E.A.3    Kaye, A.H.4    Tomlinson, F.H.5    Lavin, M.6
  • 65
    • 0030051569 scopus 로고    scopus 로고
    • Molecular analysis of the cyclin-dependent kinase inhibitor family: P16 (CDKN2/MTS1/INK4A), p18 (INK4C) and p27(Kip1) genes in neuroblastoma
    • Kawamata, N., Seriu, T., Koeffler, P. H. and Bartram, C. R. (1996). Molecular analysis of the cyclin-dependent kinase inhibitor family: p16 (CDKN2/MTS1/INK4A), p18 (INK4C) and p27(Kip1) genes in neuroblastoma. Cancer, 77, 570-575.
    • (1996) Cancer , vol.77 , pp. 570-575
    • Kawamata, N.1    Seriu, T.2    Koeffler, P.H.3    Bartram, C.R.4
  • 66
    • 0029146558 scopus 로고
    • Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocytes activation and neuronal differentiation
    • Lois, A. F., Cooper, L. T., Geng, Y., Nobori, T. and Carson, D. (1995). Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocytes activation and neuronal differentiation. Cancer Res., 55, 4010-4013.
    • (1995) Cancer Res. , vol.55 , pp. 4010-4013
    • Lois, A.F.1    Cooper, L.T.2    Geng, Y.3    Nobori, T.4    Carson, D.5
  • 68
    • 0027938776 scopus 로고
    • INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias
    • INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias. Blood, 8, 4036-4044.
    • (1994) Blood , vol.8 , pp. 4036-4044
    • Hebert, J.1    Cayuela, J.M.2    Berkeley, J.3    Sigaux, F.4
  • 71
    • 0028899626 scopus 로고
    • INK4A) deletions in primary tumor cells of 163 leukemic patients
    • INK4A) deletions in primary tumor cells of 163 leukemic patients. Blood, 85, 854-862.
    • (1995) Blood , vol.85 , pp. 854-862
    • Cayuela, J.M.1    Hebert, J.2    Sigaux, F.3
  • 73
    • 0029156293 scopus 로고
    • Refined mapping of genomic rearrangements involving the short arm of chromosome 9 in acute lymphoblastic leukemias and other hematologic malignancies
    • Dreyling, M. H., Bohlander, S K., Le Beau, M. M and Olopade, O. J. (1995). Refined mapping of genomic rearrangements involving the short arm of chromosome 9 in acute lymphoblastic leukemias and other hematologic malignancies. Blood, 86, 1931-1938.
    • (1995) Blood , vol.86 , pp. 1931-1938
    • Dreyling, M.H.1    Bohlander, S.K.2    Le Beau, M.M.3    Olopade, O.J.4
  • 75
    • 0028900889 scopus 로고
    • Homozygous deletions of p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia
    • Sill, H., Goldman, J. M and Cross, N. C. P. (1995). Homozygous deletions of p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia. Blood, 85, 2013-2016.
    • (1995) Blood , vol.85 , pp. 2013-2016
    • Sill, H.1    Goldman, J.M.2    Cross, N.C.P.3
  • 76
    • 0028875498 scopus 로고
    • Involvement of the cyclin-dependent kinase-4 inhibitor (CDKN2) gene in the pathogenesis of lymphoid blast crisis of chronic myelogenous leukemias
    • Serra, A., Gottardi, E., Della Ragione, F., Saglio, G. and Iolascon, A. (1995). Involvement of the cyclin-dependent kinase-4 inhibitor (CDKN2) gene in the pathogenesis of lymphoid blast crisis of chronic myelogenous leukemias. Brit. J. Haem., 91, 625-629.
    • (1995) Brit. J. Haem. , vol.91 , pp. 625-629
    • Serra, A.1    Gottardi, E.2    Della Ragione, F.3    Saglio, G.4    Iolascon, A.5
  • 78
    • 0029002249 scopus 로고
    • Homozygous deletion of the p15(MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia
    • Hatta, Y., Hirama, T., Miller, C. W., Yamada, Y., Tomonaga, M. and Koeffler, H P (1995). Homozygous deletion of the p15(MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia. Blood, 85, 2699-2704.
    • (1995) Blood , vol.85 , pp. 2699-2704
    • Hatta, Y.1    Hirama, T.2    Miller, C.W.3    Yamada, Y.4    Tomonaga, M.5    Koeffler, H.P.6
  • 79
    • 0029029358 scopus 로고
    • Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features
    • Fizzotti, M., Cimino, G., Pisegna, S., Alimena, G., Quartarone, C., Mandelli, F., Pellicci, P. G. and Lo Coco, F. (1995). Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features. Blood, 85, 2685-2690.
    • (1995) Blood , vol.85 , pp. 2685-2690
    • Fizzotti, M.1    Cimino, G.2    Pisegna, S.3    Alimena, G.4    Quartarone, C.5    Mandelli, F.6    Pellicci, P.G.7    Lo Coco, F.8
  • 81
    • 0028802291 scopus 로고
    • High frequency of homozygous deletions of CDK41 gene in childhood acute lymphoblastic leukemia
    • Iolascon, A., Faienza, M., Coppola, B., Delia Ragione, F., Santoro, N. and Schettini, A. (1995). High frequency of homozygous deletions of CDK41 gene in childhood acute lymphoblastic leukemia. Brit. J. Haem., 91, 647-651.
    • (1995) Brit. J. Haem. , vol.91 , pp. 647-651
    • Iolascon, A.1    Faienza, M.2    Coppola, B.3    Delia Ragione, F.4    Santoro, N.5    Schettini, A.6
  • 86
    • 0029073477 scopus 로고
    • Mutational analysis of the CDKN2(MTS1/p16INK4A) gene in primary B-cell lymphomas
    • Uchida, T., Watanabe, T., Kinoshita, T., Murate, T., Saito, H. and Hotta, T. (1995). Mutational analysis of the CDKN2(MTS1/p16INK4A) gene in primary B-cell lymphomas. Blood, 86, 2724-2731.
    • (1995) Blood , vol.86 , pp. 2724-2731
    • Uchida, T.1    Watanabe, T.2    Kinoshita, T.3    Murate, T.4    Saito, H.5    Hotta, T.6
  • 89
    • 0030031325 scopus 로고    scopus 로고
    • Deletion mapping indicates that MTS1 is the target of frequent deletions at chromosome 9p21 in paediatric acute lymphoblastic leukaemias
    • Guidal-Giroux, C., Gerrad, B., Cavé, H., Duval, M., Roharalich, P., Elion, J., Vilmer, E. and Grandchamp, B. (1996). Deletion mapping indicates that MTS1 is the target of frequent deletions at chromosome 9p21 in paediatric acute lymphoblastic leukaemias. Brit. J. Haem., 92, 410-419.
    • (1996) Brit. J. Haem. , vol.92 , pp. 410-419
    • Guidal-Giroux, C.1    Gerrad, B.2    Cavé, H.3    Duval, M.4    Roharalich, P.5    Elion, J.6    Vilmer, E.7    Grandchamp, B.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.