Pentostam induces resistance to antimony and the preservative chlorocresol in Leishmania donovani promastigotes and axenically grown amastigotes

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 5, 1997, Pages 1064-1068

  Ephros, M ^a,b   Waldman, E ^b   Zilberstein, D ^b  

^a CARMEL MEDICAL CENTER   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMONY; CHLOROCRESOL; STIBOGLUCONATE SODIUM;

AMASTIGOTE; ARTICLE; CELL DENSITY; DRUG SENSITIVITY; LEISHMANIA DONOVANI; LIFE CYCLE; MACROPHAGE; PRIORITY JOURNAL; PROMASTIGOTE; VISCERAL LEISHMANIASIS;

EID: 0030952921     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.5.1064     Document Type: Article

References (18)

1. Assaraf, Y. G., S. Drori, V. Bachrach, and V. Shaugan-Labay. 1994. Determination of multidrug resistance levels in cultured mammalian cells using ornithine decarhoxylase activity. Anal. Biochem. 216:97-109.
2. Bates, P. A., C. D. Robertson, L. Tetley, and G. H. Coombs. 1992. Axenic cultivation and characterization of Leishmania mexicana amastigotes-like forms. Parasitology 105:193-202.
3. Berman, J. D., N. Edwards, M. King, and M. Grogl. 1989. Biochemistry of pentostam resistance Leishmania. Am. J. Trop. Med. Hyg. 40:159-164.
4. Bodley, A. L., M. W. McGarry, and T. A. Shapiro. 1995. Drug cytotoxicity assay for African trypanosomes and Leishmania species. J. Infect. Dis. 172: 1157-1159.
5. Chang, K. P., and D. M. Dwyer. 1976. Multiplication of a human parasite (Leishmania donovani) in phagolysosomes of hamster macrophages in vivo. Science 193:678-680.
6. Chang, K. P., D. Fong, and R. S. Bray. 1985. The biology of Leishmania and leishmaniasis, p. 1-30. In K. P. Chang and D. Bray (ed.), Leishmaniasis. Elsevier, Amsterdam, The Netherlands.
7. Doyle, P. S., J. C. Engel, P. F. P. Pimenta, P. P. Da Silva, and D. M. Dwyer. 1991. Leishmania donovani: long-term culture of axenic amastigotes at 37°C. Exp. Parasitol. 73:326-334.
8. Dwyer, D. M. 1977. Leishmania donovani: surface membrane carbohydrate of promastigotes. Exp. Parasitol. 41:341-358.
9. Dwyer, D. M., and M. Gottlieb. 1985. The biochemistry of Leishmania surface membranes, p. 31-42. In K. P. Chang and R. S. Bray (ed.), Leishmaniasis. Elsevier Scientific, Amsterdam, The Netherlands.
10. Joshi, M., D. M. Dwyer, and H. L. Nakhasi. 1093. Cloning and characterization of expressed genes from in vitro-grown amastigotes of Leishmania donovani. Mol. Biochem. Parasitol. 58:345-354.
11. Mengeling, B. J., D. Zilberstein, and S. J. Turco. Biosynthesis of Leishmania lipophosphoglycan: solubilization and partial characterization of the initiating mannosylphosphate transferase. Glycobiology, in press.
12. Mukhopadhyay, R., and R. Madhubala. 1995. Leishmania donovani: cellular control of ornithine decarboxylase in promastigotes. Int. J. Biochem. Cell Biol. 27:947-952.
13. Naredi, P., D. D. Heath, R. E. Enns, and S. B. Howell. 1995. Cross-resistance between cisplatin, antimony potassium tartrate, and arsenite in human tumor cells. J. Clin. Invest. 95:1193-1198.
14. Roberts, W. L., J. D. Berman, and P. M. Rainey. 1995. In vitro antileishmaniai properties of tri- and pentavalent antimonial preparations. Antimicrob. Agents Chemother. 39:1234-1239.
15. Roberts, W. L., and P. M. Rainey. 1993. Antileishmanial activity of sodium stibogluconate fractions. Antimicrob. Agents Chemother. 37:1842-1846.
16. Saar, Y., E. Waldman, J. Plumblee, S. J. Turco, and D. Zilberstein. Unpublished data.
17. Steiger, R. F., and C. D. Black. 1980. Simplified defined media for cultivation of Leishmania donovani. Acta Trop. 37:698-709.
18. Zilberstein, D., and M. Shapira. 1994. The role of pH and temperature in the development of Leishmania parasites. Annu. Rev. Microbiol. 48:449-470.