Detection of CSF-specific oligoclonal antibodies to recombinant JC virus VP1 in patients with progressive multifocal leukoencephalopathy

Journal of Neuroimmunology

Volumn 76, Issue 1-2, 1997, Pages 100-104

  Sindic, C J M ^a   Trebst, C ^b   Van Antwerpen, M P ^a   Frye, S ^b   Enzensberger, W ^c   Hunsmann, G ^d   Luke W ^d   Weber, T ^e  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b Neurologische Klin Poliklin G   (Germany)

^c Neurologische Klin Poliklin J   (Germany)

^d GERMAN PRIMATE CENTER   (Germany)

^e Marienkrankenhaus Hamburg   (Germany)

Author keywords

Intrathecal humoral immunity; Oligoclonal antibodies; Progressive multifocal leukoencephalopathy; Recombinant antigen

Indexed keywords

MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN; STRUCTURAL PROTEIN; VIRUS PROTEIN;

ANTIBODY DETECTION; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; BORRELIA INFECTION; CEREBROSPINAL FLUID; CLINICAL ARTICLE; HUMAN; HUMORAL IMMUNITY; JC VIRUS; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY;

ANTIBODIES, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOBLOTTING; JC VIRUS; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL; RECOMBINANT PROTEINS; VIRAL STRUCTURAL PROTEINS;

EID: 0030952823     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00037-4     Document Type: Article

References (18)

1. Aström, K.E., Mancall, E.L. and Richardson, E.P. Jr. (1958) Progressive multifocal leukoencephalopathy: A hitherto unrecognized complication of chronic lymphocytic leukemia and lymphoma. Brain 81, 93-111.
2. Bauer, W., Chamberlin, W. and Johnson, K.P. (1973) Progressive multifocal leukoencephalopathy and cytarabine. JAMA 226, 174-176.
3. Berger, J.R. and Concha, M. (1995) Progressive multifocal leukoencephalopathy: The evolution of a disease once considered rare. J. Neurovirol. 1, 5-18.
4. Felgenhauer, K. and Reiber, H. (1992) The diagnostic significance of antibody specificity indices in multiple sclerosis and herpes virus induced diseases of the nervous system. Clin. Invest. 70, 28-37.
5. Johnson R.T. (1994) The virology of demyelinating diseases. Ann. Neurol. (suppl.) 36, S54-S60.
6. Knight, R.S.G., Hyman, N.M., Gardner, S.D., Gibson, P.E., Esiri, M.M. and Warlow, C.P. (1988) Progressive multifocal leucoencephalopathy and viral antibody titres. J. Neurol. 235, 458-461.
7. Knowles, W.A., Luxton, R.W., Hand, J.F., Gardner, S.D. and Brown, D.W.G. (1995) The JC virus antibody response in serum and cerebrospinal fluid in progressive multifocal leucoencephalopathy. Clin. Diag. Virol. 4, 183-194.
8. Luxton, R.W. and Thompson E.J. (1990) Affinity distributions of antigen-specific IgG in patients with multiple sclerosis and in patients with viral encephalitis. J. Immunol. Methods 131, 277-282.
9. Luxton, R.W., Zeman A., Holzel H., Harvey P., Wilson J., Kocen R., Morgan-Hughes J., Miller D.H., Compston A. and Thompson E.J. (1995) Affinity of antigen-specific IgG distinguishes multiple sclerosis from encephalitis. J. Neurol. Sci. 132, 11-19.
10. Mazzarello P., Poloni M., Ceroni, M. and Scelsi R. (1985) Is progressive multifocal leukoencephalopathy associated with intrathecal IgG synthesis? J. Neuroimmunol. 10, 167-172.
11. Poser, C.M., Paty, D.W., Scheinberg, L., McDonald, W.I., David, F.A., Ebers, G.C., Johnson, K.P., Sibley, W.A., Silberberg, D.H. and Tourtellotte, W.W. (1983) New diagnostic criteria for multiple sclerosis: Guidelines for research protocols. Ann. Neurol. 13, 227-231.
12. Reiber, H. and Lange, P. (1991) Quantification of virus-specific antibodies in cerebrospinal fluid and serum: Sensitive and specific detection of antibody synthesis in brain. Clin. Chem. 37, 1153-1160.
13. Sindic, C.J.M., Boucquey D., Van Antwerpen M.P., Baelden M.C., Laterre C. and Cocito C. (1990) Intrathecal synthesis of anti-mycobacterial antibodies in patients with tuberculous meningitis. An immunoblotting study. J. Neurol. Neurosurg. Psychiatry 53, 662-666.
14. Sindic, C.J.M. and Laterre, E.C. (1991) Oligoclonal free kappa and lambda bands in the cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases. An immunoaffinity-mediated capillary blot study. J. Neuroimmunol. 33, 63-72.
15. Sindic, C.J.M., Monteyne, Ph. and Laterre, E.C. (1994) The intrathecal synthesis of virus-specific oligoclonal IgG in multiple sclerosis. J. Neuroimmunol. 54, 75-80.
16. Vandvik, B., Nilsen, R.E., Vartdal, F. and Norrby, E. (1982) Mumps meningitis: Specific and non-specific antibody responses in the central nervous system. Acta Neurol. Scand. 65, 468-487.
17. Weber, Th., Freter, A., Lüer, W., Haas, J., Starrk, E., Poser, S. and Felgenhauer, K. (1991) The use of recombinant antigens in ELISA procedures for the quantification of intrathecally produced HIV-1-specific antibodies. J. Immunol. Methods 136, 133-137.
18. Weber, Th., Turner, R.W., Freye, S., Ruf, B., Haas, J. Schielke, E., Pohle, H.-D., Lüke, W. Lüer, W., Felgenhauer, K. and Hunsmann, G. (1994) Specific diagnosis of progressive multifocal leukoencephalopathy by polymerase chain reaction. J. Infect. Dis. 169, 1138-1141.