Reproductive toxicity studies of betotastine besilate in rats and rabbits

Pharmacometrics

Volumn 53, Issue 4-5, 1997, Pages 327-349

  Nishida, Atsuyuki ^a   Asano, Yuzo ^a   Hori, Masaki ^a   Izumi, Hiroyuki ^b   Kimura, Eisuke ^b   Yoshinaga, Kazuyuki ^b   Fuchigami, Katsuya ^b  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b Panapharm Laboratories Co Ltd   (Japan)

Author keywords

(rats and rabbits, p.o.); Betotastine besilate; Reproductive toxicity studies

Indexed keywords

ANTIALLERGIC AGENT; BETOTASTINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; IMPLANTATION; MALE; MYDRIASIS; NONHUMAN; ORAL DRUG ADMINISTRATION; ORGANOGENESIS; RABBIT; RAT; REPRODUCTIVE TOXICITY; TOXICITY TESTING;

EID: 0030952818     PISSN: 03008533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Biel, W.C. (1940): Early age differences in maze performance in the albino rat, J. Genet. Psychol., 56, 439-453.
2. Fidler, I.J (1977): Depression of macrophages in mice drinking hyperchlorinated water, Nature, 270, 735-736.
3. Gibson, J.P., Huffmann, K.W. and Newberne, J.W. (1982): Preclinical safety studies with Terfenadine, Arzneim.-Forsch./Drug Res., 22(II), 1179-1184.
4. Hall, C.S. (1934): Emotional behavior in the rat. 1. Defecation and urination as measures of individual differences in emotionality, J. Comp. Psychol., 18, 385-403.
5. (1990): Emedastine difumarate (KG-2413), 39, 329-342.
6. (1997): Betotastine besilate 26 53, 299-318.
7. Padilla, L., Reinicke, K., Montesino, H., Villena, F., Asencio, H., Cruz, M. and Rudolph, M.I. (1990): Histamine content and mast cells distribution in mouse uterus: the effect of sexual hormones, gestation and labar, Cell Mol. Biol., 36(1), 93-100.
8. Rudolph, M.I., Bardisa, L., Cruz, M.A. and Reinicke, K. (1992): Mast cells mediators evoke contractility and potentiate each other in mouse uterine horns. Gen. Pharmacol., 23(5), 833-836.
9. Rudolph, M.I., Reinicke, K., Cruz, M.A., Gallardo, V., Gonzalez, C. and Bardisa, L. (1993): Distribution of mast cells and the effects of their mediators on contractility in human myometrium, Br. J. Obstet. Gynaecol., 100, 1125-1130.
10. Spyker, J.M. (1975): Assessing the impact of low level chemicals on development: Behavioral and latent effects, Fed. Proc., 34, 1835-1844.
11. Staples, R.E. and Schnell, V.L. (1964): Refinements in rapid clearing technic in the KOH-alizarin red S method for fetal bone, Stain Technol., 39, 61-62.
12. Weitlauf, H.M. (1988): Biology of implantation, "The Physiology of Reproduction", ed. by Knobil, E. and Neill, J.D. et al., pp. 231-262, Raven Press, New York.
13. Wilson, J.G. (1965): Methods for administering agents and detecting malformations in experimental animals. "Teratology, Principles and Techniques", pp. 262-277, ed. by Wilson, J.G. and Warkany, J., The University of Chicago Press, Chicago.