Effects of single administration of pravastatin sodium on hepatic cholesterol metabolism in rats

European Journal of Pharmacology

Volumn 323, Issue 2-3, 1997, Pages 223-228

  Fujioka, Tomoyuki ^a   Tsujita, Yoshio ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Cholesterol 7 hydroxylase; HMG CoA (3 hydroxy 3 methylglutaryl coenzyme A) reductase; LDL (low density lipoprotein) receptor; Pravastatin sodium; Rat

Indexed keywords

CHOLESTEROL 7ALPHA MONOOXYGENASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN RECEPTOR; PRAVASTATIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; LIVER MICROSOME; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA-REDUCTASES, NADP-DEPENDENT; LIVER; MALE; MICROSOMES, LIVER; PRAVASTATIN; RATS; RATS, WISTAR; RECEPTORS, LDL;

EID: 0030952342     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00033-2     Document Type: Article

References (25)

1. Brassil, P.J., R.J. Edwards and D.S. Davies, 1995, Expression and distribution of cholesterol 7α-hydroxylase in rat liver, Biochem. Pharmacol. 50, 311.
2. Chiang, J.Y.L., W.F. Miller and G.-M. Lin, 1990, Regulation of cholesterol 7a-hydroxylase in the liver, J. Biol. Chem. 265, 3889.
3. Cosgrove, P.G., B.J. Gaynor and H.J. Harwood Jr., 1993, Measurement of total hepatic low density lipoprotein receptor levels in the hamster, J. Lipid Res. 34, 1983.
4. Endo, A., Y. Tsujita, M. Kuroda and K. Tanzawa, 1979, Effects of ML-236B on cholesterol metabolism in mice and rats: lack of hypocholesterolemic activity in normal animals, Biochim. Biophys. Acta 575, 266.
5. Fears, R., D.H. Richards and H. Ferres, 1980, The effect of compactin, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity, on cholesterogenesis and serum cholesterol levels in rats and chicks, Atherosclerosis 35, 439.
6. Fujioka, T., F. Nara, Y. Tsujita, J. Fukushige, M. Fukami and M. Kuroda, 1995, The mechanism of lack of hypocholesterolemic effects of pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in rats, Biochim. Biophys. Acta 1254, 7.
7. Grundy, S.M., 1988, HMG-CoA reductase inhibitors for treatment of hypercholesterolemia, New Engl. J. Med. 319, 24.
8. Hirano, T., F. Komuro, S. Furukawa, S. Nagano and T. Takahashi, 1990, Effects of pravastatin sodium; a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on very-low-density lipoprotein composition and kinetics in hyperlipidemia associated with experimental nephrosis, Metabolism 39, 605.
9. Horton, J.D., J.A. Cuthbert and D.K. Spady, 1995, Regulation of hepatic 7a-hydroxylase expression and responce to dietary cholesterol in the rat and hamster, J. Biol. Chem. 270, 5381.
10. Hunninghake, D.B., 1992, HMG-CoA reductase inhibitors, Curr. Opin. Lipidol. 3, 22.
11. Illingworth, D.R., 1987, Lipid-lowering drugs. An overview of indications and optimum therapeutic use, Drugs 33, 259.
12. Kuroda, M. and A. Endo, 1977, Inhibition of in vitro cholesterol synthesis by fatty acids, Biochim. Biophys. Acta 486, 70.
13. Laemmli, U.K., 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227, 680.
14. Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall, 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem. 193, 265.
15. Mabuchi, H., T. Sakai, A. Yoshimura, A. Watanabe, T. Wakasugi, J. Koizumi and R. Takeda, 1983, Reduction of serum cholesterol in heterozygous patients with familial hypercholesterolemia, New Engl. J. Med. 308, 609.
16. Ness, G.C., Z. Zhao and D. Lopez, 1996, Inhibitors of cholesterol biosynthesis increase hepatic low-density lipoprotein receptor protein degradation, Arch. Biochem. Biophys. 325, 242.
17. Nishimoto, M., O. Gotoh, K. Okuda and M. Noshiro, 1991, Structural analysis of gene encoding rat cholesterol α-hydroxylase, the key enzyme for bile acid biosynthesis, J. Biol. Chem. 266, 6467.
18. Ogishima, T. and K. Okuda, 1986, An improved method for assay of cholesterol 7α-hydroxylase activity, Anal. Biochem. 158, 228.
19. Reihner, E., M. Rudling, D. Stahlberg, L. Berglund, S. Ewerth, I. Bjorkem, K. Einarsson and B. Angelin, 1990, Influence of pravastatin, a specific inhibitor of HMG-CoA reductase and on hepatic metabolism of cholesterol, New Engl. J. Med. 323, 224.
20. Roach, P.D., S. Balasubramaniam, F. Hirata, M. Abbey, A. Szanto, L.A. Simons and P.J. Nestel, 1993, The low-density lipoprotein receptor and cholesterol synthesis are affected differently by dietary cholesterol in the rat, Biochim. Biophys. Acta 1170, 165.
21. Saito, Y., Y. Goto, N. Nakaya, Y. Hata, Y. Homma, C. Naito, H. Hayashi, H. Ito, M. Yamamoto, K. Shirai, N. Sasaki, M. Shinomiya, S. Murano, N. Morisaki, T. Nishiide, T. Nishiide, T. Kanzaki, N. Watanabe and T. Ishikawa, 1988, Dose-dependent hypolipidemic effect of an inhibitor of HMG-CoA reductase, pravastatin (CS-514) in hypercholesterolemic subjects, Atherosclerosis 723, 205.
22. Serizawa, N., K. Nakagawa, K. Hamano, Y. Tsujita, A. Terahara and H. Kuwano, 1983, Microbial hydroxylation of ML-236B (Compactin) and Monacolin K (MB-530B), J. Antibiot. 36, 604.
23. Spady, D.K. and J.A. Cuthbert, 1992, Regulation of hepatic sterol metabolism in the rat, J. Biol. Chem. 267, 5584.
24. Tsujita, Y., M. Kuroda, Y. Shimada, K. Tanzawa, M. Arai, I. Kaneko, M. Tanaka, H. Masuda, T. Tarumi, Y. Watanabe and S. Fujii, 1986, CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species, Biochim. Biophys. Acta 877, 50.
25. Yoshino, G., M. Matsushita, M. Iwai, M. Morita, K. Matsuba, T. Hirano, S. Furukawa, T. Kazumi and S. Baba, 1991, Effect of pravastatin on newly-secreted very low density lipoprotein composition in rats, Horm. Metab. Res. 2323, 193.