Inhalation anesthetics suppress the expression of c-Fos protein evoked by noxious somatic stimulation in the deeper layer of the spinal cord in the rat

Brain Research

Volumn 751, Issue 1, 1997, Pages 124-130

  Hagihira, Satoshi ^a   Taenaka, Nobuyuki ^b   Yoshiya, Ikuto ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OSAKA UNIVERSITY HOSPITAL   (Japan)

Author keywords

analgesia; c Fos; halothane; immediate early gene; nitrous oxide; rat; spinal cord

Indexed keywords

FORMALDEHYDE; HALOTHANE; INHALATION ANESTHETIC AGENT; MORPHINE; NALOXONE; NITROUS OXIDE;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; IMMEDIATE EARLY GENE; IMMUNOCYTOCHEMISTRY; INHALATIONAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; SPINAL CORD;

ANALGESIA; ANESTHETICS, INHALATION; ANIMALS; FORMALDEHYDE; HALOTHANE; HINDLIMB; MALE; NALOXONE; NARCOTIC ANTAGONISTS; NARCOTICS; NEURONS; NITROUS OXIDE; PAIN; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR; SPINAL CORD;

EID: 0030952340     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01398-4     Document Type: Article

References (34)

1. Berkowitz, B.A., Finck, A.D. and Nagi, S.H., Nitrous oxide analgesia: reversal by naloxone and development of tolerance, J. Pharmacol. Exp. Ther., 203 (1977) 539-547.
2. Besson, J.M. and Chaouch, A., Peripheral and spinal mechanisms of nociception, Physiol. Rev., 67 (1987) 67-154.
3. Bullit, E., Induction of c-fos-like protein within the lumbar spinal cord and thalamus of the rat following peripheral stimulation, Brain Res., 493 (1989) 391-397.
4. Bullitt, E., Expression of c-fos-like protein as a marker for neuronal activity following noxious stimulation in the rat, J. Comp. Neurol., 296 (1990) 517-530.
5. Curran, T. and Franza, B.R. Jr., Fos and Jun: the AP-1 connection, Cell, 55 (1988) 395-397.
6. Dragunow, M. and Faull, R., The use of c-fos as a metabolic marker in neuronal pathway tracing, J. Neurosci. Methods, 29 (1989) 261-265.
7. Dubuisson, D. and Dennnis, S.G., The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats, Pain, 4 (1977) 161-174.
8. E.I. Eger, II, Bahlman, S.H. and Munson, E.S., The effect of age on the rate of increase of alveolar concentration, Anesthesiology, 35 (1971) 365-372.
9. Gillman, M.A., Nitrous oxide, an opioid additive agent, Am. J. Med., 81 (1986) 97-102.
10. Hsu, S.M., Raine, L. and Fanger, H., Use of avidin-biothin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between abc and unlabeled antibody (PAP) procedures, J. Histochem. Cytochem., 29 (1981) 577-580.
11. Hunt, S.P., Pini, A. and Evan, G., Induction of c-fos-like protein in spinal cord neurons following sensory stimulation, Nature, 328 (1987) 632-634.
12. Kitahata, L.M., Taub, A. and Sato, I., Lamina-specific suppression of dorsal horn unit activity by nitrous oxide and by hyperventilation, J. Parmacol Exp. Ther., 176 (1971) 101-108.
13. Kitahata, L.M., Ghazi-Saidi, K., Yamashita, M., Kosaka, Y., Bonikos, C. and Taub, A., Depressant effect of halothane and sodium thiopental on the spontaneous and evoked activity of dorsal horn cells: lamina specificity, time course and dose dependence, J. Parmacol Exp. Ther., 195 (1975) 515-521.
14. Lawrence, D. and Livingston, A., Opiate-like analgesic activity in general anesthetics, Br. J. Pharmacol., 73 (1981) 435-442.
15. Marota, J.J.A., Crosby, G. and Uhl, G.R., Selective effects of pentobarbital and halothane on c-fos and jun-B gene expression in rat brain, Anesthesiology, 77 (1992) 365-371.
16. Mazze, R.I., Rice, S.A. and Baden, J.M., Halothane, Isoflurane, and Enflurane MAC in pregnant and nonpregnant female and male mice and rats, Anesthesiology, 62 (1985) 339-341.
17. Menétrey, D., Gannon, A., Levine, J.D. and Basbaum, A.I., Expression of c-fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation, J. Comp. Neurol., 285 (1989) 177-195.
18. Müller, R., Cellular and viral fos genes: structure, regulation of expression and biological properties of their encoded products, Biochem. Biophys. Acta, 823 (1986) 207-225.
19. Naranjo, J.R., Mellstrom, B. and Achaval, M., Molecular pathways of pain: Fos/Jun-mediated activation of a noncanonical AP-1 site in the prodynorphin gene, Neuron, 6 (1991) 607-617.
20. Pertovaara, A., Bravo, R. and Herdegen, T., Induction and suppression of immediate-early genes in the rat brain by a selective alpha-2-adrenoceptor agonist and antagonist following noxious peripheral stimulation, Neuroscience, 54 (1993) 117-126.
21. Presley, R.W., Menétrey, D., Levine, J. and Basbaum, A.I., Systemic morphine suppresses noxious stimulus-evoked fos protein-like immuno-reactivity in the rat spinal cord, J. Neurosci., 10 (1990) 323-335.
22. Quock, R.M. and Graczak, L.M., Influence of narcotic antagonist drugs upon nitrous oxide analgesia in mice, Brain Res., 440 (1988) 35-41.
23. Rampil, I.J. and Laster, M.J., No correlation between quantitative electroencephalographic measurements and movement response to noxious stimuli during isoflurane anesthesia, Anesthesiology, 77 (1992) 920-925.
24. Sheng, M. and Greenberg, M.E., The regulation and function of c-fos and other immediate early genes in the nervous system, Neuron, 4 (1990) 477-485.
25. Shingu, K., Osawa, M., Omatsu, Y., Komatsu, T., Urabe, N. and Mori, K., Naloxone does not antagonize the anaethetic-induced depression of nociceptive-driven spinal cord response in spinal cats, Acta Anaesth. Scand., 25 (1981) 526-532.
26. Smith, R.A., Wilson, M. and Miller, K.W., Naloxone has no effect on nitrous oxide anesthesia, Anesthesiology, 49 (1978) 6-8.
27. Sun, W.Z., Shyu, B.C. and Shieh, J.Y., Nitrous oxide or halothane, or both, fail to suppress c-fos expression in rat spinal cord dorsal horn neurones after subcutaneous formalin, Br. J. Anaesth., 76 (1996) 99-105.
28. Tjølsen, A., Berge, O., Hunskaar, S., Posland, J.H. and Hole, K., The formalin test: An evaluation of the method, Pain, 51 (1992) 5-17.
29. Tölle, T.R., Herdegen, T., Schadrack, J., Bravo, R., Zimmerman, M. and Zieglgänsberger, W., Application of morphine prior to noxious stimulation differentially modulates expression of Fos, Jun, Krox-24 proteins in rat spinal cord neurons, Neuroscience, 58 (1994) 305-321.
30. Wahrenbrock, E.A., E.I. Eger, II, Laravuso, R.B. and Maruschak, G., Anesthetic uptake of mice and men (and whales), Anesthesiology, 40 (1974) 19-23.
31. White, P.E., Johnston, R.R. and E.I. Eger, II, Determination of anesthetic requirement in rats, Anesthesiology, 40 (1974) 52-57.
32. Williams, S., Evan, G.I. and Hunt, S.P., Changeing patterns of c-fos induction in spinal neurons following thermal cutaneous stimulation in the rat, Neuroscience, 39 (1990) 73-81.
33. Williams, S., Evan, G.I. and Hunt, S.P. Spinal c-fos induction by sensory stimulation in neonatal rats, Neurosci. Lett., 109 (1990) 309-314.
34. Zamboni, L. and Martino, D.G., Buffered picric acid formaldehyde: a new rapid fixative for electron microscopy, J. Cell Biol., 35 (1967) 148A.