Vaccaroid A, a new triterpenoid saponin with contractility of rat uterine from Vaccaria segetalis

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 8, 1997, Pages 1095-1096

  Morita, Hiroshi ^a   Yun, Young Sook ^a   Takeya, Koichi ^a   Itokawa, Hideji ^a   Yamada, Kenji ^a   Shirota, Osamu ^b  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TRITERPENOID;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYTOCHEMISTRY; PLANT; RAT; UTERUS CONTRACTION;

EID: 0030952272     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00168-6     Document Type: Article

References (9)

1. Kee Chang Huang, The Pharmacology of Chinese Herbs, CRC Press, London and Tokyo, 1994, pp 254.
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5. Y.S. Yun, H. Morita, K. Takeya, H. Itokawa, J. Nat. Prod., in press.
6. 1H NMR (400MHz, pyridine-d5) δ 0.84 (H-29), 0.86 (H-30), 1.03 (H-25), 1.09 (H-26), 1.18 (H-27), 1.65 (H-24), 3.15 (H-18), 4.68 (H-3), 5.43 (H-12), 6.21 (Glc-A, H-1, J=7.5), 4.26 (Glc-A, H-2), 4.28 (Glc-A, H-3), 4.34 (Glc-A, H-4), 4.14 (Glc-A, H-5), 4.25/4.46 (Glc-A, H-6), 5.34 (Glc-B, H-1, J=8.4), 4.67 (Glc-B, H-2), 4.14 (Glc-B, H-3), 4.16 (Glc-B, H-4), 3.91 (Glc-B, H-5), 4.46/4.56 (Glc-B, H-6), 5.30 (Glc-C, H-1, J=8.1), 4.05 (Glc-C, H-2), 4.14 (Glc-C, H-3), 4.16 (Glc-C, H-4), 3.91 (Glc-C, H-5), 4.25/4.32 (Glc-C, H-6), 5.00 (Glc-D, H-1, J=7.7), 4.06 (Glc-D, H-2), 4.06 (Glc-D, H-3), 3.91 (Glc-D, H-4), 3.79 (Glc-D, H-5), 4.38/4.42 (Glc-D, H-6).
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9. Oxytocin showed 1.60±0.23 g tension at 0.1 I.U. These uterine contractions are significantly difference from control (saline) by multiple comparison of Dunnet (p<0.05).