Detection of benzodiazepines in human urine by direct immersion solid phase micro extraction and gas chromatography

Japanese Journal of Forensic Toxicology

Volumn 15, Issue 1, 1997, Pages 16-20

  Seno, Hiroshi ^a   Kumazawa, Takeshi ^b   Ishii, Akira ^a   Watanabe, Kanako ^c   Hattori, Hideki ^c   Suzuki, Osamu ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHOWA UNIVERSITY   (Japan)

^c AICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

benzodiazepines; diazepam; direct immersion method; fludiazepam; gas chromatography; medazepam; solid phase micro extraction (SPME)

Indexed keywords

ALPRAZOLAM; BENZODIAZEPINE DERIVATIVE; BROTIZOLAM; DIAZEPAM; ESTAZOLAM; ETIZOLAM; FLUDIAZEPAM; FLUNITRAZEPAM; FLURAZEPAM; MEDAZEPAM; MIDAZOLAM; NIMETAZEPAM; PRAZEPAM; TRIAZOLAM;

ARTICLE; CHEMICAL ANALYSIS; DRUG URINE LEVEL; GAS CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IMMERSION; SOLID PHASE EXTRACTION;

EID: 0030951544     PISSN: 09159606     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Wodak, A. and Pedersen, C.: A death from combined alcohol and benzodiazepine poisoning in a non-medical detoxification unit. Med J Aust, 156, 814 (1992).
2. Chern, C.-H., Chern, T.-L., Hu, S.-C., Lee, C.-H. and Deng, J.-F.: Complete and partial response to flumazenil in patients with suspected benzodiazepine overdose. Am J Emerg Med, 13, 372-375 (1995).
3. West, R.E. and Ritz, D.P.: GC/MS analysis of five common benzodiazepine metabolites in urine as tert-butyl-dimethylsilyl derivatives. J Anal Toxicol, 17, 114-116 (1993).
4. Gaillard, Y., Gay-Montchamp, J.-P. and Ollagnier, M.: Simultaneous screening and quantitation of alpidem, zolpidem, buspirone and benzodiazepines by dual-channel gas chromatography using electron-capture and nitrogen-phosphorus detection after solid-phase extraction. J Chromatogr, 622, 197-208 (1993).
5. Moore, C., Long, G. and Marr, M.: Confirmation of benzodiazepines in urine as trimethylsilyl derivatives using gas chromatography-mass spectrometry. J Chromatogr B, 635, 132-137 (1994).
6. Arthur, C.L. and Pawliszyn, J.: Solid phase microextraction with thermal desorption using fused silica optical fibers. Anal Chem, 62, 2145-2148 (1990).
7. Kumazawa, T., Watanabe, K., Sato, K., Seno, H., Ishii, A. and Suzuki, O.: Detection of cocaine in human urine by solid-phase microextraction and capillary gas chromatography with nitrogen-phosphorus detection. Jpn J Forensic Toxicol, 13, 207-210 (1995).
8. Kumazawa, T., Sato, K., Seno, H., Ishii, A. and Suzuki, O.: Extraction of local anaesthetics from human blood by direct immersion-solid phase micro extraction (SPME). Chromatographia, 43, 59-62 (1996).
9. Ishii, A., Seno, H., Kumazawa, T., Nishikawa, M., Watanabe, K., Hattori, H. and Suzuki, O.: Simple clean-up of methamphetamine and amphetamine in human urine by direct-immersion solid phase micro extraction (DI-SPME). Jpn J Forensic Toxicol, 14, 228-232 (1996).