Nitric oxide and thermoregulation during exercise in the horse

Journal of Applied Physiology

Volumn 82, Issue 4, 1997, Pages 1035-1039

  Mills, Paul C ^a   Marlin, David J ^a   Scott, Caroline M ^a   Smith, Nicola C ^a  

^a ANIMAL HEALTH TRUST   (United Kingdom)

Author keywords

N(G) nitro L arginine methyl ester; nitric oxide; sweating rate

Indexed keywords

ARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL TONE; BODY TEMPERATURE; CONTROLLED STUDY; CORE TEMPERATURE; HORSE; NONADRENERGIC NONCHOLINERGIC NERVE; NONHUMAN; PHYSICAL STRESS; PRIORITY JOURNAL; RECTUM TEMPERATURE; SKIN TEMPERATURE; SWEATING; THERMOREGULATION; TREADMILL EXERCISE; VASOCONSTRICTION;

EID: 0030951404     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1997.82.4.1035     Document Type: Article

References (37)

1. G-nitro-L-arginine methyl ester, on cerebral and myocardial blood flows during hypoxia in the awake dog. Anesth. Analg. 81: 945-951, 1995.
2. Bijman, J., and P. M. Quinton. Predominantly β-adrenergic control of equine sweating. Am. J. Physiol. 246 (Regulatory Integrative Comp. Physiol. 15): R349-R353, 1984.
3. Cabanac, M., and M. D. White. Core temperature thresholds for hyperpnea during passive hyperthermia in humans. Eur. J. Appl. Physiol. Occup. Physiol. 71: 71-76, 1995.
4. Dietz, N. M., J. M. Rivera, D. O. Warner, and M. J. Joyner. Is nitric oxide involved in cutaneous vasodilation during body heating in humans? J. Appl. Physiol. 76: 2047-2053, 1994.
5. Endo, T., T. Imaizumi, T. Tagawa, M. Shiramoto, S. Ando, and A. Takeshita. Role of nitric oxide in exercise-induced vasodilation of the forearm. Circulation 90: 2886-2890, 1994.
6. Gardiner, S. M., A. M. Compton, T. Bennett, R. M. J. Palmer, and S. Moncada. Control of regional blood flow by endothelium-derived nitric oxide. Hypertension 15: 486-492, 1990.
7. Gerstberger, R., H. Hjelmqvist, and R. Keil. Nitric oxide modulates thermoregulatory effector mechanisms in the conscious rabbit. Therm. Bal. Health Dis. 23: 485-495, 1994.
8. Gilligan, D. M., J. A. Panza, C. M. Kilcoyne, M. A. Waclawiw, P. R. Casino, and A. A. Quyyumi. Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation. Circulation 90: 2853-2858, 1994.
9. Hirai, T., M. D. Visneski, K. J. Kearns, R. Zelis, and T. I. Musch. Effects of NO synthase inhibition on the muscular blood flow response to treadmill exercise in rats. J. Appl. Physiol. 77: 1288-1293, 1994.
10. Hodgson, D. R., L. J. McCutcheon, S. K. Byrd, W. S. Brown, W. M. Bayly, G. L. Brengelmann, and P. D. Gollnick. Dissipation of metabolic heat in the horse during exercise. J. Appl. Physiol. 74: 1161-1170, 1993.
11. Johnson, J. M., and M. K. Park. Effect of upright exercise on threshold for cutaneous vasodilation and sweating. J. Appl. Physiol. 50: 814-818, 1981.
12. Kane, D. W., T. Tesauro, T. Koizumi, R. Gupta, and J. H. Newman. Exercise-induced pulmonary vasoconstriction during combined blockade of nitric oxide synthase and beta adrenergic receptors. J. Clin. Invest. 93: 677-683, 1994.
13. Kellogg, D. L., J. M. Johnson, and W. A. Kosiba. Control of internal temperature threshold for active cutaneous vasodilation by dynamic exercise. J. Appl. Physiol. 71: 2476-2482, 1991.
14. Koizumi, T., R. Gupta, M. Banerjee, and J. H. Newman. Changes in pulmonary vascular tone during exercise: effects of nitric oxide (NO) synthase inhibition, L-arginine infusion, and NO inhalation. J. Clin. Invest. 94: 2275-2282, 1994.
15. Mevio, E., and L. Bernardi. Phasic changes in human nasal and skin blood flow: relationship with autonomic tone. Ann. Otol. Rhinol. Laryngol. 103: 789-795, 1994.
16. Mills, P. C., D. J. Marlin, and C. M. Scott. Pulmonary artery pressure in the horse during exercise after inhibition of nitric oxide synthase. Br. Vet. J. 152: 1-4, 1996.
17. Moncada, S., R. M. J. Palmer, and E. A. Higgs. Nitric oxide physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43: 109-142, 1991.
18. Nadel, E. R., R. W. Bullard, and J. A. J. Stolwijk. Importance of skin temperature in the regulation of sweating. J. Appl. Physiol. 31: 80-87, 1971.
19. Nadel, E. R., J. W. Mitchell, B. Saltin, and J. A. J. Stolwijk. Peripheral modifications to the central drive for sweating. J. Appl. Physiol. 31: 828-832, 1971.
20. Nagashima, T., H. Ohinata, and A. Kuroshima. Involvement of nitric oxide in noradrenaline-induced increase in blood flow through brown adipose tissue. Life Sci. 54: 17-25, 1994.
21. Ozaki, M., A. Kurz, D. I. Sessler, R. Lenhardt, M. Schroeder, A. Moayeri, K. M. Noyes, and E. Rotheneder. Thermoregulatory thresholds during epidural and spinal anesthesia. Anesthesiology 81: 282-288, 1994.
22. Peterson, D. A., D. C. Peterson, S. Archer, and E. K. Weir. The nonspecificity of specific nitric oxide synthase inhibitors. Biochem. Biophys. Res. Commun. 187: 797-801, 1992.
23. Rowell, L. B. Cutaneous vascular circulation and exercise. In: Human Circulation. Regulation During Physical Stress. Oxford, UK: Clarendon, 1986, p. 57-82.
24. G-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic activity in vivo: a role for nitric oxide in the central regulation of sympathetic tone? Circ. Res. 70: 607-611, 1992.
25. ω-nitro-L-arginine (L-NA) and its methyl ester (L-NAME). Neuropharmacology 34: 639-649, 1995.
26. Saltin, B., A. P. Gagge, U. Bergh, and J. A. J. Stolwijk. Body temperatures and sweating during exhaustive exercise. J. Appl. Physiol. 32: 635-643, 1972.
27. Sato, K., and F. Sato. Pharmacological responsiveness of isolated eccrine sweat glands. Am. J. Physiol. 240 (Regulatory Integrative Comp. Physiol. 9): R44-R51, 1981.
28. Scott, C. M., D. J. Marlin, and R. C. Schroter. A modified ventilated capsule for the measurement of sweating rate in the exercising horse. Equine Vet. J. Suppl. 22: 48-56, 1996.
29. Solack, S. D., G. L. Brengelmann, and P. R. Freund. Sweat rate vs. forearm blood flow during lower body negative pressure. J. Appl. Physiol. 58: 1546-1552, 1985.
30. Sugenoya, J., T. Ogawa, K. Jmai, N. Ohnishi, and K. Natsume. Cutaneous vasodilation responses synchronise with sweat expulsions. Eur. J. Appl. Physiol. Occup. Physiol. 71: 33-40, 1995.
31. Takahata, T., O. Shido, and M. Tanabe. Influence of venous blood return from the hand on forearm skin blood flow and sweating rate during exercise in humans. J. Therm. Biol. 4: 237-243, 1993.
32. Taylor, W. F., and V. S. Bishop. A role for nitric oxide in active thermoregulatory vasodilation. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H1355-H1359, 1993.
33. Taylor, W. F., J. M. Johnson, W. A. Kosiba, and C. M. Kwan. Graded cutaneous vascular response to dynamic leg exercise. J. Appl. Physiol. 64: 1803-1809, 1988.
34. Togashi, H., I. Sakamura, M. Yoshioka, T. Kobayashi, H. Yasuda, A. Kitibataki, H. Saito, S. S. Gross, and R. Levi. A central nervous system action of nitric oxide in blood pressure regulation. J. Pharmacol. Exp. Ther. 262: 343-347, 1992.
35. Vanhoutte, P. M., and N. A. Flavahan. Effects of temperature on alpha-adrenoceptor in limb veins: role of receptor temperatures. Federation Proc. 45: 2347-2354, 1986.
36. Vizzard, M. A., S. L. Erdman, V. L. Erickson, R. J. Stewart, J. R. Roppolo, and W. C. Degroat. Localization of NADPH diaphorase in the lumbosacral spinal cord and dorsal root ganglia of the cat. J. Comp. Neurol. 339: 62-75, 1994.
37. Wilson, S. M., J. D. Pediani, W. H. Ko, D. L. Bovell, S. Kitson, I. Montgomery, U. M. O. Brown, G. L. Smith, H. Y. Elder, and D. M. Jenkinson. Investigation of stimulus-secretion coupling in equine sweat gland epithelia using cell culture techniques. J. Exp. Biol. 183: 279-299, 1993.