Rare occurrence of ras and p53 gene mutations in mouse stomach tumors induced by N-methyl-N-nitrosourea

Japanese Journal of Cancer Research

Volumn 88, Issue 4, 1997, Pages 363-368

  Furihata, Chie ^a   Tatematsu, Masae ^b   Saito, Masae ^a   Ishida, Shizuka ^a   Nakanishi, Hayao ^b   Inada, Ken Ichi ^b   Tei, Hajime ^a   Hattori, Masahira ^a   Ito, Takashi ^a   Sakaki, Yoshiyuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

Mouse; N methyl N nitrosourea; p53; ras; Stomach tumor

Indexed keywords

DNA; METHYLNITROSOUREA; PROTEIN P53;

ADENOMA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER GENETICS; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DNA SEQUENCE; EXON; MALE; MOUSE; NONHUMAN; ONCOGENE H RAS; ONCOGENE K RAS; ONCOGENE N RAS; ONCOGENE RAS; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; STOMACH ADENOCARCINOMA; STOMACH TUMOR; TUMOR SUPPRESSOR GENE;

EID: 0030951239     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1997.tb00390.x     Document Type: Article

References (25)

1. Zarbl, H., Sukumar, S., Arthur, A. V., Martin-Zanca, D. and Barbacid, M. Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature, 315, 382-385 (1985).
2. Newcomb, E. W., Steinberg, J. J. and Pellicer, A. Ras oncogenes and phenotypic staging in N-methylnitrosoureaand γ-irradiation-induced thymic lymphomas in C57BL/ 6J mice. Cancer Res., 48, 5514-5521 (1988).
3. Murase, T., Niwa, K., Morishita, S., Itoh, N., Mori, H., Tanaka, T. and Tayama, T. Rare occurrence of p53 and ras gene mutations in preneoplastic and neoplastic mouse endometrial lesions induced by N-methyl-N-nitrosourea and 17β-estradiol. Cancer Lett., 92, 223-227 (1995).
4. Brathwaite, O., Bayona, W. and Newcomb, E. W. p53 mutations in C57BL/6J murine thymic lymphomas induced by γ-irradiation and JV-methylnitrosourea. Cancer Res., 52, 3791-3795 (1992).
5. Asamoto, M., Mann, A. M. and Cohen, S. M. p53 mutation is infrequent and might not give a growth advantage in rat bladder carcinogenesis in vivo. Carcinogenesis, 15, 455-458 (1994).
6. Furihata, C., Sasajima, K., Kazama, S., Kogure, K., Kawachi, T., Sugimura, T., Tatematsu, M. and Takahashi, M. Changes in pepsinogen isozymes in stomach carcinogenesis induced in rats by N-methyl-N'-nitro-N-nitroso-guanidine. J. Natl. Cancer Inst., 55, 925-930 (1975).
7. Furihata, C., Yamawaki, Y., Jin, S.-S., Moriya, H., Kodama, K., Matsushima, T., Ishikawa, T., Takayama, S. and Nakadate, M. Induction of unscheduled DNA synthesis in rat stomach mucosa by glandular stomach carcinogens. J. Natl. Cancer Inst., 72, 1327-1334 (1984).
8. Furihata, C., Sato, Y., Hosaka, M., Matsushima, T., Furukawa, F. and Takahashi, M. NaCl induced ornithine decarboxylase and DNA synthesis in rat stomach mucosa. Biochem. Biophys. Res. Commun., 121, 1027-1032 (1984).
9. Furihata, C., Hatta, A., Sato, Y. and Matsushima, T. Alkaline elution of DNA from stomach pyloric mucosa of rats treated with glyoxal. Mutat. Res., 21, 227-231 (1989).
10. Furihata, C., Yamakoshi, A., Hatta, A., Tatematsu, M., Iwata, H., Hayashi, K., Umezawa, K. and Matsushima, T. Induction of c-fos and c-myc oncogene expression in the pyloric mucosa of rat stomach by N-methyl-N'-nitro-N-nitrosoguanidine and taurocholate. Cancer Lett., 83, 215-220 (1994).
11. Tatematsu, M., Ogawa, K., Hoshiya, T., Shichino, Y., Kato, T., Imaida, K. and Ito, N. Induction of adenocar- cinomas in the glandular stomach of BALB/c mice treated with N-methyl-N-nitrosourea. Jpn. J. Cancer Res., 83, 915-918 (1992).
12. Tatematsu, M., Yamamoto, M., Iwata, H., Fukami, H., Yuasa, H., Tezuka, N., Masui, T. and Nakanishi, H. Induction of glandular stomach cancers in C3H mice treated with N-methyl-N-nitrosourea in the drinking water. Jpn. J. Cancer Res., 84, 1258-1264 (1993).
13. Manam, S. and Nichols, W. W. Multiple polymerase chain reaction amplification and direct sequencing of homologous sequences: point mutation analysis. Anal. Biochem., 199, 106-111 (1991).
14. Qi, S.-L., Akagi, K., Araki, K., Miyazaki, J. and Yamamura, K. Rapid identification of transgenic mice with PCR amplification of DNA from ear punching. Methods Mol. Cell. Biol., 2, 119-122 (1991).
15. Ballhausen, W. G. and Kraus, C. Non-isotopic detection of single-stranded conformation polymorphisms using ethidium bromide/UV light. Appl. Theor. Electrophor., 3, 129-131 (1993).
16. Hongyo, T., Buzard, G. S., Calvert, R. J. and Weghorst, C. M. "Cold-SSCP": a simple, rapid and non-radioactive method for optimized single-strand conformation polymorphism analyses. Nucleic Acids Res., 21, 3637-3642 (1993).
17. Sukumar, S., Armstrong, B., Bruyntjes, J. P., Leeav, I. and Bosland, M. C. Frequent activation of the Ki-ras oncogene at codon 12 in N-methyl-N-nitrosourea-induced rat prostate adenocarcinomas and neurogenic sarcomas. Mol. Carcinog., 4, 362-368 (1991).
18. Yamamoto, S., Masui, T., Murai, T., Mori, S., Oohara, T., Makino, S., Fukushima, S. and Tatematsu, M. Frequent mutations of the p53 gene and infrequent H- and K-ras mutations in urinary bladder carcinomas of NON/Shi mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 16, 2363-2368 (1995).
19. Masui, T., Dong, Y., Yamamoto, S., Takada, N., Nakanishi, H., Inada, K., Fukushima, S. and Tatematsu, M. p53 mutations in transitional cell carcinomas of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Cancer Lett., 105, 105-112 (1996).
20. Berg, R. J., van Kranen, H. J., Rebel, H. G., de Vries, A., van Vloten, W. A., van Kreijl, C. F., van der Leun, J. C. and de Gruijl, F. R. Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells. Proc. Natl. Acad. Sci. USA, 93, 274-278 (1996).
21. Koshiba, M., Ogawa, O., Habuchi, T., Hamazaki, S., Shimada, T., Takahashi, R. and Sugiyama, T. Infrequent ras mutation in human stomach cancers. Jpn. J. Cancer Res., 84, 163-167 (1993).
22. Bos, J. L. The ras gene family and human carcinogenesis. Mutat. Res., 195, 255-271 (1988).
23. Gomyo, Y., Osaki, M., Kaibara, N. and Ito, H. Numerical aberration and point mutation of p53 gene in human gastric intestinal metaplasia and well-differentiated adenocarcinoma: analysis by fluorescence in situ hybridiza- tion (FISH) and PCR-SSCP. Int. J. Cancer, 66, 594-599 (1996).
24. Semba, S., Yokozaki, H., Yamamoto, S., Yasui, W. and Tahara, E. Microsatellite instability in precancerous lesions and adenocarcinomas of the stomach. Cancer, 77, 1620-1627 (1996).
25. Yokota, J., Yamamoto, T., Miyajima, N., Toyoshima, K., Nomura, N., Sakamoto, T., Yoshida, T., Terada, M. and Sugimura, T. Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homolog. Oncogene, 2, 283-287 (1988).