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Volumn 10, Issue 2, 1997, Pages 115-120

Generalized epilepsies: Emerging insights into cellular and genetic mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; EPILEPSY; GENETIC REGULATION; GRAND MAL SEIZURE; HUMAN; MYOCLONUS SEIZURE;

EID: 0030950987     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019052-199704000-00008     Document Type: Article
Times cited : (18)

References (64)
  • 1
    • 0018942104 scopus 로고
    • GABA neurons are the major cell type of the nucleus reticularis thalami
    • Houser CR, Vaughn JE, Barber RP, Roberts E: GABA neurons are the major cell type of the nucleus reticularis thalami. Brain Res 1980, 200:431-435.
    • (1980) Brain Res , vol.200 , pp. 431-435
    • Houser, C.R.1    Vaughn, J.E.2    Barber, R.P.3    Roberts, E.4
  • 2
    • 0023688791 scopus 로고
    • The functional states of the thalamus and the associated neuronal interplay
    • Steriade M, Llinás RF: The functional states of the thalamus and the associated neuronal interplay. Physiol Rev 1988, 68.649-742.
    • (1988) Physiol Rev , vol.68 , pp. 649-742
    • Steriade, M.1    Llinás, R.F.2
  • 3
    • 0027445242 scopus 로고
    • Thalamocortical oscillations in the sleeping and aroused brain
    • Steriade M, McCormick DA, Sejnowski T: Thalamocortical oscillations in the sleeping and aroused brain. Science 1993, 262:679-685.
    • (1993) Science , vol.262 , pp. 679-685
    • Steriade, M.1    McCormick, D.A.2    Sejnowski, T.3
  • 4
    • 0342369968 scopus 로고
    • Abolition of spindle oscillations in thalamic neurons disconnected from NRT
    • Steriade M, Deschênes M, Domich L, Mulle C: Abolition of spindle oscillations in thalamic neurons disconnected from NRT. J Neurophysiol 1985, 37: 1065-1092.
    • (1985) J Neurophysiol , vol.37 , pp. 1065-1092
    • Steriade, M.1    Deschênes, M.2    Domich, L.3    Mulle, C.4
  • 5
    • 0022470777 scopus 로고
    • Morphology and elecrophysiological properties of reticularis thalami neurons in cat: In vivo study of a thalamic pacemaker
    • Mulle C, Madariaga A, Deschênes M: Morphology and elecrophysiological properties of reticularis thalami neurons in cat: in vivo study of a thalamic pacemaker. J Neurosci 1986, 6:2134-2145.
    • (1986) J Neurosci , vol.6 , pp. 2134-2145
    • Mulle, C.1    Madariaga, A.2    Deschênes, M.3
  • 6
    • 0025924527 scopus 로고
    • B receptors in excltation and inhibition of thalamocortlcal cells
    • B receptors In excltation and inhibition of thalamocortlcal cells. Trends Neurol Sci 1991, 14:16-21..
    • (1991) Trends Neurol Sci , vol.14 , pp. 16-21
    • Crunelli, V.1    Leresche, N.2
  • 7
    • 0027169922 scopus 로고
    • Cellular mechanisms of a synchronized oscillation in the thalamus
    • von Krosigk M, Bal T, McCormick DA: Cellular mechanisms of a synchronized oscillation in the thalamus. Science 1993, 261:361-364.
    • (1993) Science , vol.261 , pp. 361-364
    • Von Krosigk, M.1    Bal, T.2    McCormick, D.A.3
  • 8
    • 0028174189 scopus 로고
    • B inhibition in thalamic relay neurons through effects in nucleus reticularis
    • B inhibition in thalamic relay neurons through effects in nucleus reticularis. J Neurophysiol 1994, 71:2576-2581.
    • (1994) J Neurophysiol , vol.71 , pp. 2576-2581
    • Huguenard, J.1    Prince, D.2
  • 9
    • 0028915751 scopus 로고
    • Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro
    • Bal T, von Krosigk M, McCormick DA: Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro. J Physiol 1995, 483:641-663.
    • (1995) J Physiol , vol.483 , pp. 641-663
    • Bal, T.1    Von Krosigk, M.2    McCormick, D.A.3
  • 10
    • 0028933304 scopus 로고
    • Role of the ferret perigeniculate nucleus in the generation of synchronized oscillations in vitro
    • Bal T, von Krosigk M, McCormick DA: Role of the ferret perigeniculate nucleus in the generation of synchronized oscillations in vitro. J Physiol 1995, 483:665-685.
    • (1995) J Physiol , vol.483 , pp. 665-685
    • Bal, T.1    Von Krosigk, M.2    McCormick, D.A.3
  • 11
    • 0024549009 scopus 로고
    • Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons
    • Coulter DA, Huguenard JR, Prince DA: Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons. Neurosci Lett 1989, 98:74-78.
    • (1989) Neurosci Lett , vol.98 , pp. 74-78
    • Coulter, D.A.1    Huguenard, J.R.2    Prince, D.A.3
  • 12
    • 0024324889 scopus 로고
    • Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons
    • Coulter DA, Huguenard JR, Prince DA: Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann Neurol 1989, 25:582-593.
    • (1989) Ann Neurol , vol.25 , pp. 582-593
    • Coulter, D.A.1    Huguenard, J.R.2    Prince, D.A.3
  • 13
    • 0024318689 scopus 로고
    • Calcium currents in rat thalamocortical relay neurones: Kinetic properties of the transient, low-threshold current
    • Coulter DA, Huguenard JR, Prince DA: Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low-threshold current. J Physiol 1989, 414:587-604.
    • (1989) J Physiol , vol.414 , pp. 587-604
    • Coulter, D.A.1    Huguenard, J.R.2    Prince, D.A.3
  • 14
    • 0026612477 scopus 로고
    • B-mediated mechanisms in experimental generalized absence seizures
    • B-mediated mechanisms in experimental generalized absence seizures. Eur J Pharmacol 1992, 213:343-349.
    • (1992) Eur J Pharmacol , vol.213 , pp. 343-349
    • Snead, O.C.1
  • 18
    • 0029023018 scopus 로고
    • B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole models
    • B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole models. J Pharmacol Exp Ther 1995, 274:1399-1403.
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 1399-1403
    • Hosford, D.A.1    Wang, Y.2    Liu, C.C.3    Snead, O.C.4
  • 19
    • 0030202885 scopus 로고    scopus 로고
    • B mechanisms in animal models of absence seizures
    • B mechanisms in animal models of absence seizures. Molec Neurobiol 1996, 12:67-76.
    • (1996) Molec Neurobiol , vol.12 , pp. 67-76
    • Caddick, S.J.1    Hosford, D.A.2
  • 20
    • 0029160327 scopus 로고
    • Postnatal development of synchronized network oscillations in the ferret dorsal lateral geniculate and perigeniculate nuclei
    • McCormick DA, Trent F, Ramoa AS: Postnatal development of synchronized network oscillations In the ferret dorsal lateral geniculate and perigeniculate nuclei. J Neurosci 1995, 15:5739-5752.
    • (1995) J Neurosci , vol.15 , pp. 5739-5752
    • McCormick, D.A.1    Trent, F.2    Ramoa, A.S.3
  • 21
    • 0029076314 scopus 로고
    • Spindle waves are propagating synchronized oscillations in the ferret LGNd in vitro
    • Kim U, Bal T, McCormick DA: Spindle waves are propagating synchronized oscillations in the ferret LGNd in vitro. J Neurophysiol 1995, 74:1301-1323.
    • (1995) J Neurophysiol , vol.74 , pp. 1301-1323
    • Kim, U.1    Bal, T.2    McCormick, D.A.3
  • 22
    • 0025762396 scopus 로고
    • Evidence for a critical role of GABAergic transmission within the thalamus in the genesis and control of absence seizures in the rat
    • Liu Z, Vergnes M, Depaulis A, Marescaux C Evidence for a critical role of GABAergic transmission within the thalamus in the genesis and control of absence seizures in the rat. Brain Res 1991, 545:1-7.
    • (1991) Brain Res , vol.545 , pp. 1-7
    • Liu, Z.1    Vergnes, M.2    Depaulis, A.3    Marescaux, C.4
  • 23
    • 0030985886 scopus 로고    scopus 로고
    • A receptors in thalamic nuclei in IhIIh model of absence seizures
    • In press
    • A receptors in thalamic nuclei in IhIIh model of absence seizures. Epilepsy Res 1997 (In press).
    • (1997) Epilepsy Res
    • Hosford, D.A.1    Wang, Y.2    Cao, Z.3
  • 24
    • 0028985493 scopus 로고
    • A receptor function in somatosensory thalamus and cortex: Whole-cell voltage-clamp recordings in acutely isolated rat neurons
    • A receptor function in somatosensory thalamus and cortex: whole-cell voltage-clamp recordings in acutely isolated rat neurons. J Neurosci 1995, 15:1341-1351.
    • (1995) J Neurosci , vol.15 , pp. 1341-1351
    • Oh, K.-S.1    Lee, C.-J.2    Gibbs, J.W.3    Coulter, D.A.4
  • 25
    • 0029658051 scopus 로고    scopus 로고
    • A receptor function in developing rat thalamic reticular neurons: Whole-cell recordings of GABA-mediated currents and modulation by clonazepam
    • A receptors to GABA and benzodiazepines suggest that there may be temporal and regional specificity in the ability of the thalamocortical circuit to generate synchronized burst-firing.
    • (1996) J Neurophysiol , vol.76 , pp. 2568-2579
    • Gibbs, J.W.1    Schroder, G.B.2    Coulter, D.A.3
  • 26
    • 0029133853 scopus 로고
    • Extracellular GABA in the ventrolateral thalamus of rats exhibiting spontaneous absence epilepsy: A microdialysis study
    • Richards DA, Lemos T, Whitton PS, Bowery NG: Extracellular GABA In the ventrolateral thalamus of rats exhibiting spontaneous absence epilepsy: a microdialysis study. J Neurochem 1995, 65:1674-1680.
    • (1995) J Neurochem , vol.65 , pp. 1674-1680
    • Richards, D.A.1    Lemos, T.2    Whitton, P.S.3    Bowery, N.G.4
  • 27
    • 0029053175 scopus 로고
    • B receptor-mediated release of GABA and glutamate in rat thalamic ventrobasal nucleus: A possible mechanism for the generation of absence-like seizures induced by GHB
    • B receptor-mediated release of GABA and glutamate in rat thalamic ventrobasal nucleus: a possible mechanism for the generation of absence-like seizures induced by GHB. J Pharmacol Exp Ther 1995, 273:1534-1543.
    • (1995) J Pharmacol Exp Ther , vol.273 , pp. 1534-1543
    • Banerjee, P.K.1    Snead, O.C.2
  • 29
    • 0029662280 scopus 로고    scopus 로고
    • + in thalamic neurons in the lethargic (IhIIh) mouse model of generalized absence seizures
    • + in thalamic neurons in the lethargic (IhIIh) mouse model of generalized absence seizures. Neurosci Lett 1996, 205:29-32.
    • (1996) Neurosci Lett , vol.205 , pp. 29-32
    • Caddick, S.J.1    Hosford, D.A.2
  • 30
    • 0022649265 scopus 로고
    • Acetylcholine induces burst firing in thalamic retlcular neurons by activating a potassium conductance
    • McCormick DA, Prince DA: Acetylcholine induces burst firing in thalamic retlcular neurons by activating a potassium conductance. Nature 1986, 319:402-405.
    • (1986) Nature , vol.319 , pp. 402-405
    • McCormick, D.A.1    Prince, D.A.2
  • 31
    • 0023948034 scopus 로고
    • Noradrenergic modulation of firing pattern in guinea pig and cat thalamic neurons, in vitro
    • McCormick DA, Prince DA: Noradrenergic modulation of firing pattern in guinea pig and cat thalamic neurons, in vitro. J Neurophysiol 1988, 59:978-996.
    • (1988) J Neurophysiol , vol.59 , pp. 978-996
    • McCormick, D.A.1    Prince, D.A.2
  • 32
    • 0026003378 scopus 로고
    • Serotonin and noradrenaline excite GABAergic neurons of the guinea pig and cat thalamic reticular nucleus
    • McCormick DA, Wang Z. Serotonin and noradrenaline excite GABAergic neurons of the guinea pig and cat thalamic reticular nucleus. J Physiol 1991, 442:235-255.
    • (1991) J Physiol , vol.442 , pp. 235-255
    • McCormick, D.A.1    Wang, Z.2
  • 34
    • 0030068416 scopus 로고    scopus 로고
    • In vivo, in vitro, and computational analysis of dendritic calcium currents in thalamic reticular neurons
    • Destexe A, Contreras D, Steriade M, Sejnowski TJ, Huguenard JR: • In vivo, in vitro, and computational analysis of dendritic calcium currents in thalamic reticular neurons. J Neurosci 1996, 16:169-185. The density of T-channels on distal dendrites may be a key determinant of the ability of NRT neurons to respond to neuronal inputs and thereby to synchronize burst-firing of thalamocortical seizures.
    • (1996) J Neurosci , vol.16 , pp. 169-185
    • Destexe, A.1    Contreras, D.2    Steriade, M.3    Sejnowski, T.J.4    Huguenard, J.R.5
  • 35
    • 0029046218 scopus 로고
    • Single locus mutations in mice expressing generalized spike-wave absence epilepsies
    • Noebels JL: Single locus mutations in mice expressing generalized spike-wave absence epilepsies. Ital J Neurol Sci 1995, 16:623-627.
    • (1995) Ital J Neurol Sci , vol.16 , pp. 623-627
    • Noebels, J.L.1
  • 38
    • 0028301325 scopus 로고
    • Calcium channels: Cellular roles and molecular mechanisms
    • McCleskey EW: Calcium channels: cellular roles and molecular mechanisms. Curr Opin Neurobiol 1994, 4:314-312.
    • (1994) Curr Opin Neurobiol , vol.4 , pp. 314-1312
    • McCleskey, E.W.1
  • 40
    • 0027237602 scopus 로고
    • Distinctive biophysical and pharmacological properties of class a (B1) calcium channel α1 subunits
    • Sather WA, Tanabe T, Zhang J-F, Mori Y, Adams ME, Tsien RW: Distinctive biophysical and pharmacological properties of class A (B1) calcium channel α1 subunits. Neuron 1993, 11:291-303.
    • (1993) Neuron , vol.11 , pp. 291-303
    • Sather, W.A.1    Tanabe, T.2    Zhang, J.-F.3    Mori, Y.4    Adams, M.E.5    Tsien, R.W.6
  • 41
    • 0028020678 scopus 로고
    • Localization and functional properties of a rat brain α1A calcium channel reflect similarities to neuronal Q- and P-type channels
    • Stea A, Tomlinson WJ, Soong TW, Bourinet E, Dubel SJ, Vincent SR, Snutch TP: Localization and functional properties of a rat brain α1A calcium channel reflect similarities to neuronal Q- and P-type channels. Proc Natl Acad Sci U S A 1994, 91:10576-10580.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10576-10580
    • Stea, A.1    Tomlinson, W.J.2    Soong, T.W.3    Bourinet, E.4    Dubel, S.J.5    Vincent, S.R.6    Snutch, T.P.7
  • 48
    • 0027314930 scopus 로고
    • Progressive myoclonus epilepsies: Clinical and genetic aspects
    • Berkovic SF, Cochius J, Andermann E, Andermann F: Progressive myoclonus epilepsies: clinical and genetic aspects. Epilepsia 1993, 34(suppl 3):S19-S30.
    • (1993) Epilepsia , vol.34 , Issue.3 SUPPL.
    • Berkovic, S.F.1    Cochius, J.2    Andermann, E.3    Andermann, F.4
  • 50
    • 0025817602 scopus 로고
    • The cystatins: Protein inhibitors of cysteine proteinases
    • Turk V, Bode W: The cystatins: protein inhibitors of cysteine proteinases. FEBS Lett 1991, 285:213-219.
    • (1991) FEBS Lett , vol.285 , pp. 213-219
    • Turk, V.1    Bode, W.2
  • 52
    • 0029927015 scopus 로고    scopus 로고
    • Shaking down new epilepsy genes
    • Allen KM, Walsh C: Shaking down new epilepsy genes. Nature Med 1996, 2:516-518.
    • (1996) Nature Med , vol.2 , pp. 516-518
    • Allen, K.M.1    Walsh, C.2
  • 59
    • 0029876438 scopus 로고    scopus 로고
    • Abnormalities in brain serotonin concentration, high-affinity uptake, and tryptophan hydroxylase activity in severe-seizure GEPRs
    • Statnick MA, Dailey JW, Jobe PC, Browning RA: Abnormalities in brain serotonin concentration, high-affinity uptake, and tryptophan hydroxylase activity in severe-seizure GEPRs. Epilepsia 1996, 37: 311-321.
    • (1996) Epilepsia , vol.37 , pp. 311-321
    • Statnick, M.A.1    Dailey, J.W.2    Jobe, P.C.3    Browning, R.A.4
  • 60
    • 0029670753 scopus 로고    scopus 로고
    • 1B receptor binding in severe-seizure GEPR-9S
    • 1B receptor binding in severe-seizure GEPR-9S. Neuropharmacology 1996, 35:111-118. These findings suggest that selective alterations in binding sites or other key features of serotonergic neurotransmission may underlie generalized tonic clonic seizures in the GEPR-95 model.
    • (1996) Neuropharmacology , vol.35 , pp. 111-118
    • Statnick, M.A.1    Dailey, J.W.2    Jobe, P.C.3    Browning, R.A.4
  • 61
    • 0029000061 scopus 로고
    • Lissencephaly and other malformations of cortical development: 1995 update
    • Dobyns WB, Truwit CL: Lissencephaly and other malformations of cortical development: 1995 update. Neuropediatrics 1995, 26:132-147.
    • (1995) Neuropediatrics , vol.26 , pp. 132-147
    • Dobyns, W.B.1    Truwit, C.L.2
  • 62
    • 0030027091 scopus 로고    scopus 로고
    • Periventricular heterotopla: An X-linked dominant epilepsy locus causing aberrant cerebral cortical development
    • Eksioglu YZ, Scheffer IE, Cardenas P, Knoll J, DiMario F, Ramsby G, •• Berg M, Kamuro K, Berkovic SF, Duyk GM et al.: Periventricular heterotopla: an X-linked dominant epilepsy locus causing aberrant cerebral cortical development. Neuron 1996, 16:77-87. A gene located distally on the long arm of the X-chromosome was linked to generalized tonic clonic seizures in human patients with a particular form of lissencephaly.
    • (1996) Neuron , vol.16 , pp. 77-87
    • Eksioglu, Y.Z.1    Scheffer, I.E.2    Cardenas, P.3    Knoll, J.4    DiMario, F.5    Ramsby, G.6    Berg, M.7    Kamuro, K.8    Berkovic, S.F.9    Duyk, G.M.10
  • 64
    • 0028023599 scopus 로고
    • Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor
    • Hattori M, Adachl H, Trujimoto M, Arai H, Inoue K: Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor. Nature 1994, 370:216-218.
    • (1994) Nature , vol.370 , pp. 216-218
    • Hattori, M.1    Adachl, H.2    Trujimoto, M.3    Arai, H.4    Inoue, K.5


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