1-[3-(aryloxy) propyl]-diamines: A new class of non-steroidal basic antiinflammatory agents. Structure-activity studies: Part II

Research Communications in Molecular Pathology and Pharmacology

Volumn 95, Issue 3, 1997, Pages 319-329

  Hadjipavlou Litina, Dimitra ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; BETA GLUCURONIDASE; CARRAGEENAN; INDOMETACIN; LIPOXYGENASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; PHENYLBUTAZONE; PROPYLDIAMINE DERIVATIVE; SALICYLATE SODIUM; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG EFFECT; DRUG POTENCY; ENZYME INHIBITION; FEMALE; MALE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; BEPRIDIL; DIAMINES; DISEASE MODELS, ANIMAL; EDEMA; FEMALE; LIPOXYGENASE INHIBITORS; MALE; PICRATES; RATS; RATS, INBRED F344; SOYBEAN PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030950865     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Blois M.S (1958) Antioxidant Determinations by the use of a Stable Free Radical. Nature(London) 181, 1199.
2. Brain S.D. Williams T.J. (1990) Leukotrienes and Inflammation. Pharm. Ther. 46, 57-66.
3. th Ed., p.454.
4. De Witt D.L., Meade E.A., Smith W.L. (1993) PGH Synthase Isoenzyme Selectivity:The potential for safer Nonsteroidal Antiinflammatory Drugs. Am.J.Med. 95(suppl.2A), 2A-40S-2A-44S.
5. Flohe L., Beckman R., Giertz H., Loschen G. (1985) Oxygen centered free radicals as mediators of inflammation. In: Oxidative Stress, Edited by: Sies H. Academic Press, London, pp. 403-435.
6. Gusslandi M. (1987) Gastric effects of Leukotrienes. Prostaglandins, Leukotriene Med. 26, 203-208.
7. Hadjipavlou-Litina D. (1993) Antiinflammatory, analgesic, antiproteolytic and ulcerogenic activities of some new 1-[3-(aryloxy)-propyl]diamines. Res. Commun. Chem. Pathol. Pharmacol. 81,1, 91-102.
8. Hadjipavlou-Litina D., Kourounakis P.N. (1992) Synthesis of some new 1-[3-(aryloxy)-propyl]-ethyldiamines. Abstracts 6th Hellenic Pharmaceutical Congres p.157.
9. Hamberg M., Samuelson B., Bjorkem I., Danielson H. (1974). In: Molecular Mechanisms of Oxygen Activation . Edited by: Hayashi O. Academic Press New York p.29.
10. Hansch C., Leo A. (1979) In: Substituent Constants For Correlation Analysis In Chemistry And Biology. J.Wiley and Sons.
11. Ito K., Kagaya H., Satoh I., Tsukamoto G., Nose T. (1982) The studies of the mechanism of antiinflammatory action of 2-(ethylpyridin-2-yl)-benzimidazole (KB-1043). Arzneim.-Forsch./Drug Res. 32(I), 117-122.
12. Kato K., Terao S., Shinamoto N., Hirata M. (1988) Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids. J.Med.Chem. 31, 793-798.
13. Kemp G., Webster A., Russel W.C (1992) In: Essays in Biochemistry vol. 27, Ed.Tipton K.F., Portland Press p.1-14.
14. Lands W.E., Kulmacz R.J., Marshall P.J. (1984) In: Free Radicals In Biology. Academic press Orlando, vol. VI p.39.
15. Naito Y., Sugiura M., Yamaura Y., Fukaya C., Yokayama K., Nakagawa Y., Ikeda T., Senda M., Fujita T. (1991) Quantitative structure-activity relationship of catechol derivatives inhibiting 5-lipoxygenase. Chem. Pharm. Bull. 39, 1736-1745.
16. 2 synthase and 5-Lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridyl-methyl)-benzoquinone derivatives J.Med.Chem. 34, 267-276.
17. Ratty A.K., Sunamoto J., Das N.P., (1988) Interaction of flavonoids with 1,1-diphenyl-2-picrylhydrazyl free radical, liposomal membranes and soybean lipoxygenase-1. Biochem. Pharmacol. 37, 989-995.
18. Roberfroid M.B., Viehe H.G., Remacle J. (1987) Free radicals in drug research. Edited by: Testa B. Advances In Drug Research vol. 16, Academic Press, London pp.1-84.
19. Samuelsson B.Z.(1991) Arachidonic acid metabolism: Role in Inflammation Z. Rheumatol. 50(suppl. 1), 3-6.
20. Shen T.Y. (1980) Nonsteroidal antiinflammatory agents.In: Burger's Medicinal Chemistry. Edited by: Wolff M.E J.Wiley and Sons chapter 62, p.1216-1219.
21. Tandon M., Tandon P., Barthwal J.P., Bhalla T.N., Bhargava K.P. (1982) Antiinflammatory and antiproteolytic activities of newer indolylisoquinilines. Arzneim.-Forsch./Drug Res. 32(II), 10, 1233-1235.
22. Taraborewala I.B., Kauffman J.M.(1990) Synthesis and structure-activity relationships of antiinflammatory 9,10-Dihydro-9-oxo-2-acridine-alkanoic acids and 4-(2-carboxyphenyl)aminobenzenealkanoic acids. J. Pharm. Sci. 79, 173-178.
23. Vaananen P.M., Keenan C.M., Grisham M.B., Wallace J.L. (1992) Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy. Inflammation 16, 227-240.
24. Vane J.R. (1971) Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs. Nature (London) 231, 232-235.
25. 2 inhibitors. II. Design, synthesis and structure-activity relationship. Eur.J.Med.Chem. 27, 595-610.
26. Xie W., Robertson D.L., Simons D.L. (1992) Mitogen-inducible prostaglandin G/h Synthase: A new target for nonsteroidal antiinflammatory drugs. Drug Develop.Res. 25, 249-265.