Novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridines. Potent angiotensin II receptor antagonists with high affinity for both the AT1 and AT2 subtypes

European Journal of Medicinal Chemistry

Volumn 32, Issue 6, 1997, Pages 479-491

  Mederski, W W K R ^a   Dorsch, D ^a   Osswald, M ^a   Schwartz, H ^a   Beier, N ^a   Christadler, M ^a   Minck, K O ^a   Schelling, P ^a   Schmitges, C J ^a  

^a MERCK KGAA   (Germany)

Author keywords

4,5 dihydro 4 oxo 3H imidazo 4,5c pyridine; Angiotensin II receptor antagonist; Antihyperensive activity; AT1; AT2 receptor subtype; Biphenylsulfonamide

Indexed keywords

ANGIOTENSIN II ANTAGONIST; ANGIOTENSIN II I 125; ANGIOTENSIN RECEPTOR; ANTIHYPERTENSIVE AGENT; EMD 90423; IMIDAZO[4,5 C]PYRIDINE DERIVATIVE; LOSARTAN; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ADRENAL CORTEX; ADRENAL MEDULLA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; AORTA; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG STABILITY; DRUG SYNTHESIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LIVER MICROSOME; MALE; MONKEY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL DRUG ADMINISTRATION; RABBIT; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

EID: 0030950385     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(97)84011-1     Document Type: Article

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