A two-locus model for hereditary non-polyposis colorectal cancer in Modena, Italy

Annals of Human Genetics

Volumn 61, Issue 2, 1997, Pages 109-119

  Scapoli, C ^a   Collins, A ^b   Benatti, P ^b   Percesepe, A ^b   Roncucci, L ^b   Ponz De Leon, M ^b  

^a UNIVERSITY OF FERRARA   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER REGISTRY; COLORECTAL CANCER; FAMILIAL CANCER; FEMALE; GENE LOCUS; GENETIC MODEL; GENETIC SUSCEPTIBILITY; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; PENETRANCE; PRIORITY JOURNAL;

ADULT; AGE OF ONSET; AGED; CHROMOSOME MAPPING; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; FEMALE; GENETIC HETEROGENEITY; HUMANS; ITALY; MALE; MIDDLE AGED; MODELS, GENETIC; PEDIGREE;

EID: 0030950029     PISSN: 00034800     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0003480097006003     Document Type: Article

References (24)

1. BENATTI, P., SASSATELLI, R., RONCUCCI, L. et al. (1993). Tumour spectrum in hereditary non-polyposis colorectal cancer (HNPCC) and in families with 'Suspected HNPCC'. A population-based study in northern Italy. Int. J. Cancer. 54, 371-377.
2. BOLAND, C. R. (1993). The biology of colorectal cancer. Implications for pre-treatment and follow-up management. Cancer 71, 4180-4186.
3. BRONNER, C. E., BAKER, S. M., MORRISON, P. T. et al. (1994). Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368, 258-261.
4. FISHEL, R., LESCOE, M. K., RAO, M. R. S. et al. (1993). The human mutation gene homologue MSH2 and its association with hereditary non-polyposis colon cancer. Cell 75, 1027-1038.
5. ISELIUS, L., SLACK, J., LITTLER, M. et al. (1991). Genetic epidemiology of breast cancer in Britain. Ann. Hum. Genet. 55, 151-159.
6. LYNCH, H. T., DROUHARD, T., VASEN, H. F. A. et al. (1996). Genetic counselling in a Navajo hereditary non-polyposis colorectal cancer kindred. Cancer 77, 30-35.
7. LYNCH, H. T., LANSPA, S., SMYRK, T. et al. (1991). Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). Cancer Genet. Cytogenet. 53, 143-160.
8. MELLON, I., RAJPAL, D. K., KOI, M. et al. (1996). Transcription-coupled repair deficiency and mutations in human mismatch repair genes. Science 272, 557-560.
9. MODICA, S., RONCUCCI, L., BENATTI, P. et al. (1995). Familial aggregation of tumours and detection of hereditary non-polyposis colorectal cancer in 3-year experience of 2 population-based colorectal-cancer registries. Int. J. Cancer. 62, 685-690.
10. MORTON, N. E. (1991). Pitfalls and prospects in genetic epidemiology of cancer. In Recent progress in genetic epidemiology of cancer (ed. H. T. Lynch & P. Tautu), pp 18-26. Heidelberg: Springer-Verlag.
11. MORTON, N. E., RAO, D. C. & LALOUEL, J. M. (1983). Methods in genetic epidemiology, ch. 5, pp. 62-08. Basel: Karger.
12. MORTON, N. E., SHIELDS, D. C. & COLLINS, A. (1991). Genetic epidemiology of complex phenotypes. Ann. Hum. Genet. 55, 301-314.
13. Min: a mouse model for intestinal and mammary tumorigenesis. Eur. J. Cancer 31(A), 1061-1064.
14. PELTOMAKI, P. T. (1994). Genetic basis of hereditary nonpolyposis colorectal carcinoma (HNPCC). Annals of Medicine 26, 215-219.
15. PERCESEPE, A., ANTI, M., RONCUCCI, L. et al. (1995). The effect of family size on estimates of the frequency of hereditary non-polyposis colorectal cancer. Br. J. Cancer 72, 1320-1323.
16. PONZ DE LEON, M., SASSATELLI, R., BENATTI, P. et al. (1993a). Identification of hereditary nonpolyposis colorectal cancer in the general population. The 6-year experience of a population-based registry. Cancer 71, 3493-3501.
17. PONZ DE LEON, M., SASSATELLI, R., SCALMATI, A. et al. (1991). Epidemiology of tumours of the colon and rectum: incidence, mortality, familiarity and survival in the Health Care District of Modena, 1984-1989, pp. 1-42. Modena: Artioli.
18. PONZ DE LEON, M., SASSATELLI, R., SCALMATI, A. et al. (1993b). Descriptive epidemiology of colorectal cancer in Italy: the 6-year experience of a specialised registry. Eur. J. Cancer 29(A), 367-371.
19. PONZ DE LEON, M., SCAPOLI, C., ZANGHIERI, G. et al. (1992). Genetic transmission of colorectal cancer: exploratory data analysis from a population-based registry. J. Med. Gen. 29, 531-538.
20. PROLLA, T. A., PANG, Q., ALANI, E. et al. (1994). MLH1, PMS1 and MSH2 interactions during the initiation of DNA mismatch repair in yeast. Science 265, 1091-1093.
21. SCAPOLI, C., PONZ DE LEON, M., SASSATELLI, R. et al. (1994). Genetic epidemiology of hereditary non polyposis colorectal cancer syndromes in Modena. Italy: results of a complex segregation analysis. Ann. Hum. Genet. 58, 275-295.
22. SHIELDS, D. C., MARLOW, A. J., HOULSTON, R. S. et al. (1994). Prediction of genetic risks from segregation analyses of morbid risks. Hum. Hered. 44, 52-55.
23. VASEN, H. F. A., MECKLIN, J-P., MEERA KHAN, P. et al. (1991). The international collaborative group on hereditary non-polyposis colorectal cancer (ICG-HNPCC). Dis. Colon Rectum 34, 424-425.
24. VASEN, H. F. A., OFFERHAUS, G. J. A., FRIEDA, C. A. et al. (1990). The tumour spectrum in hereditary nonpolyposis colorectal cancer: a study of 24 kindreds in the Netherlands. Int. J. Cancer 46, 31-34.