Comparative effects of cefadroxil and phenoxymethylpenicillin on the normal oropharyngeal and intestinal microflora

Infection

Volumn 25, Issue 3, 1997, Pages 154-158

  Adamsson, I ^a   Edlund, C ^a   Sjostedt S ^a   Nord, C E ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CEFADROXIL; PENICILLIN V;

ADULT; AEROBIC BACTERIUM; ALPHA HEMOLYTIC STREPTOCOCCUS; ANAEROBIC BACTERIUM; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL COUNT; FECES ANALYSIS; HUMAN; INTESTINE FLORA; MALE; MICROFLORA; NEISSERIA; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; OROPHARYNX; SPECIES DIFFERENCE;

EID: 0030950023     PISSN: 03008126     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02113603     Document Type: Article

References (12)

1. Blumer, J. L., Goldfarb, J.: Rediscovering pharmacological values in antimicrobial therapy. Cefadroxil in perspective. Drugs 32 (1986) v-viii.
2. Edlund, C., Nord, C. E.: Ecological impact of antimicrobial agents on human intestinal microflora. Alpe Adria Microbiol. J. 3 (1993) 137-164.
3. Edlund, C., Stark, C., Nord, C. E.: The relationship between an increase in β-lactamase activity after oral administration of three new cephalosporins and protection against intestinal ecological disturbances. J. Antimicrob. Chemother. 34 (1994) 127-138.
4. Heimdahl, A., Nord, C. E.: Effect of phenoxymethylpenicillin and clindamycin on the oral, throat and faecal microflora of man. Scand. J. Infect. Dis. 11 (1979) 233-242.
5. Nord, C. E.: Studies on the ecological impact of antibiotics. Eur. J. Clin. Microbiol. Infect. Dis. 9 (1990) 517-518.
6. van der Waaij, D.: The ecology of the human intestine and its consequences for overgrowth by pathogens such as Clostridium difficile. Ann. Rev. Microbiol. 43 (1989) 69-87.
7. Hill, M. J.: The normal gut bacterial flora. In: Hill, M. J. (ed.): Role of gut bacteria in human toxicology and pharmacology. Taylor & Francis Ltd., London 1995, pp. 3-17.
8. Rang, H. P., Dale, M. M.: Pharmacology. 2nd ed. Churchill Livingstone, Edinburgh 1991, pp. 804-832.
9. Tunér, K., Nord, C. E.: Impact of phenoxymethylpenicillin and clindamycin on microflora in recurrent tonsillitis. Ann. Otol. Rhinol. Laryngol. 94 (1985) 278-280.
10. Deeter, R. G., Kalman, D. L., Rogan, M. P., Chow, S.-H.: Therapy for tonsillitis caused by group A beta-haemolytic streptococci: a meta-analysis comparing the efficacy and safety of cefadroxil monohydrate versus oral penicillin V. Clin. Ther. 14 (1992) 740-754.
11. Sprunt, K., Redman, W.: Evidence suggesting importance of role of interbacterial inhibition in maintaining balance of normal flora. Ann. Intern. Med. 68 (1968) 579-590.
12. Alcaide, F., Linares, J., Pallares, R., Carratala, J., Benilez, M. A., Gudiol, F., Martin, R.: In vitro activity of 22 β-lactam antibiotics against penicillin-resistant and penicillin-susceptible viridans group streptococci isolated from blood. Antimicrob. Agents Chemother. 39 (1995) 2243-2247.